Crystal of Human Glycoprotein VI Collagen Binding Domain

ABSTRACT

A crystal comprising the collagen binding domain of human GPVI is provided and defined by structural atomic coordinates. Employing computer modeling based on the crystal structure, including methods for identifying inhibitors of GPVI collagen binding activity, methods for screening libraries of compounds for potential to bind to the GPVI collagen binding domain, and methods of identifying a compound useful for the treatment of a GPVI-mediated disorder, are also provided.

RELATED APPLICATIONS

This application is a divisional of U.S. patent application Ser. No. 12/294,581 filed Aug. 6, 2010, which is filed under 35 U.S.C. §371 as a national stage of PCT/US07/07900 filed Mar. 28, 2007, which claims priority under 35 U.S.C. §119 to U.S. Provisional Application Ser. No. 60/786,656 filed Mar. 28, 2006.

FIELD OF THE INVENTION

The present invention relates to determining a structural basis for the ability of an immune-type receptor to generate signaling responses to collagen in the context of the pathogenesis of cardiovascular disease, thereby permitting the development of new pharmacological therapies. In particular, the invention provides the crystalline structure of the collagen-binding domain of human GPVI and the characterization of its interaction with a collagen-related peptide.

BACKGROUND OF THE INVENTION

Thrombus formation in the arterial vasculature is a process initiated by the interaction of several platelet receptors with collagen and collagen-associated proteins at the site of vascular injury. Investigators have determined that, initially, platelets are tethered transiently to exposed collagen when the receptor GPIbα interacts with collagen-bound von Willebrand factor (vWF) (Ruggeri et al. 2002). For stable platelet adhesion to occur, the immunoglobulin (Ig)-like receptor GPVI must bind to collagen, triggering the activation of a signaling cascade (Moroi et al. Thromb Res. 2004), and Kahn et al. Semin Thromb Hemost. 2004). GPVI signaling leads to inside-out activation of the platelet integrins α₂β₁ and α_(IIb)β₃ (Nieswandt et al. EMBO J. 2001, and Chen et al. Mol Cell Biol. 2003). Activated α₂β₁ binds tightly to a specific sequence in collagen to allow firm adhesion of the platelets to the site of injury and activated α_(IIb)β₃ mediates platelet aggregation (Bennett et al. J Clin Invest. 2005). In addition, GPVI signaling stimulates secretion of platelet granule contents to activate nearby circulating platelets and propagate thrombus formation. In humans, GPVI deficiency causes a loss of platelet activation in response to collagen, and GPVI polymorphisms have been linked to increased risk of myocardial infarction. Remarkably, loss or inhibition of GPVI prevents arterial thrombus formation in animal models but causes only mildly prolonged bleeding times in mice and humans, suggesting that GPVI could be a prime therapeutic target for prevention of arterial thrombotic diseases such as heart attack and stroke.

The gene for GPVI is found in the leukocyte receptor cluster (LRC) on human chromosome 19. The sequence of the GPVI ectodomain was predicted to form two Ig-like domains comprising the collagen-binding domain followed by a heavily O-glycosylated stalk Like other LRC receptors, GPVI associates with the FcR γ-chain co-receptor, and signaling is mediated both indirectly through the γ-chain and directly through the GPVI cytoplasmic domain. The quaternary structure of fibrous collagen is required for GPVI activation, although GPVI can also be activated by a synthetic collagen-related peptide (CRP) containing crosslinked strands of the repeating tripeptide (POG)_(n), where P is proline, O is hydroxyproline, and G is glycine (Farndale et al. J Thromb Haemost. 2004). Recently, GPVI has been shown to interact with the ectodomain of GPIbα on the surface of platelets (Arthur et al. Thromb Haemost. 2005) and to bind to laminin, a matrix protein exposed at sites of vascular injury (Inoue et al. Blood. 2005). Multimeric snake venom proteins such as convulxin can also strongly activate GPVI (Lu et al. Toxicon. 2005), suggesting that clustering of GPVI receptors through multiple binding events leads to activation. To better understand the molecular basis for collagen activation of platelets by GPVI, determining the crystal structure of the collagen-binding domain (CBD) of human GPVI and characterizing its interaction with CRP is highly desirable.

SUMMARY OF THE INVENTION

Accordingly, the present inventors determined the crystal structure of the collagen-binding domain of human GPVI and have characterized its interaction with a collagen-related peptide. Like related immune receptors, GPVI contains two immunoglobulin-like domains arranged in a perpendicular orientation. Significantly, GPVI forms a back-to-back dimer in the crystal, an arrangement that could explain data previously obtained from cell-surface GPVI inhibition studies. Docking algorithms identify two parallel grooves on the GPVI dimer surface as collagen-binding sites, and the orientation and spacing of these grooves precisely match the dimensions of an intact collagen fiber. Based on these findings, the present invention provides a structural basis for the ability of an immune-type receptor to generate signaling responses to collagen and for the development of GPVI inhibitors as new therapies for human cardiovascular disease.

One embodiment is directed to a crystal comprising the collagen binding domain of human GPVI having an amino acid sequence substantially similar to the sequence designated SEQ ID NO: 1. The crystal diffracts X-rays for determination of atomic coordinates to provide resolution of better than about 5.0 Angstroms. The crystal has a three-dimensional structure comprising main chain and side chain atoms and atomic coordinates set forth in Table 2. One aspect includes a computer readable storage device or article encoded with computer readable data comprising the atomic coordinates set forth in Table 2.

Another embodiment provides a method of identifying an inhibitor of GPVI collagen binding activity. The method comprises: (1) designing or selecting a potential inhibitor using a three-dimensional structure of the GPVI collagen binding domain comprising main chain and side chain atoms and as defined by atomic coordinates set forth in Table 2, plus or minus a root mean square deviation for the main chain atoms of not greater than 3 Angstroms; (2) synthesizing or obtaining the potential inhibitor; and (3) determining whether the potential inhibitor inhibits the activity of GPVI, wherein designing or selecting a potential inhibitor employs computer modeling.

An embodiment directed to a method of screening a library of compounds for potential to bind to the GPVI collagen binding domain is also provided. The method comprises: using at least some of the atomic coordinates set forth Table 2 to perform computational docking of the library of compounds to the GPVI collagen binding domain.

A further embodiment is directed to a method of identifying a compound useful for the treatment of a GPVI-mediated disorder. The method comprises the steps of: (a) using a three-dimensional structure of the GPVI collagen binding domain as defined by at least some of the atomic coordinates set forth in Table 2, and (b) employing the structure to design, modify, or select a compound that modulates GPVI activity.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1. Structure of the GPVI CBD. A. Ribbon diagram of GPVI. The N-terminal domain is labeled D1, and the C-terminal domain is D2. The predicted N-glycosylation site at N72 is shown by a ball. B. Simulated annealing electron density omit map showing the C′E region of the CBD that differs from related immune receptors, with a ball-and-stick model of the deleted region superimposed. C. Superposition of GPVI (thick lines), p58 KIR (Fan et al. Nature 1997), and FcαRI (Herr et al. Nature 2003) (thin lines). The orientation is similar to that shown in panel A. D. Superposition of D1 of GPVI and p58 KIR (Fan et al. Nature 1997) shown in two orientations, highlighting the unusual C′E region in GPVI (arrows). E. Superposition of D2 of GPVI (darker gray) and p58 KIR (Fan et al. Nature 1997) (lighter gray) in two orientations, highlighting the lack of an A′ strand and the extended CC′ hairpin in GPVI (note arrows).

FIG. 2. Dimeric conformation of GPVI in the crystal. A. Structure of the GPVI dimer in the asymmetric unit. B. Electrostatic potential of GPVI mapped onto the surface of each GPVI protomer, shown in an “open-book” view. Residues contributing to the dimer interface on each protomer have been outlined in light gray. The potential map has been contoured from −100 to +100 kT. C. Left, Stereoview of a superposition of the dimers formed by GPVI D2 and the CD3ε7 heterodimer (Kjer-Nielsen et al. Proc Natl Acad Sci USA. 2004). For clarity, only those β-strands in the continuous β-sheet are shown as ribbons; all others are shown as coils.

FIG. 3. GPVI-CRP binding affinity and stoichiometry. A. Normalized sedimentation velocity size distribution from a titration of 6.7 μM GPVI with CRP (1.7 to 240 μM). The two extreme cases (unligated GPVI at 0 μM CRP and fully ligated GPVI at 240 μM) are illustrated with thick lines and labeled. All other curves are shown by varying shades of gray. Inset: fitting the s_(w) values as a function of CRP concentration to a binding isotherm yields a K_(D) of 5 μM. B. Normalized sedimentation velocity size distributions for 1:1, 4:1, and 8:1 GPVI:CRP mixtures (dashed lines), with the free GPVI and final 1:1 complex from panel A included for comparison (solid thick lines). Note that the mixtures with 4- and 8-fold molar excess of GPVI form complexes larger than a 1:1 complex (thick dark gray line).

FIG. 4. Computational docking of CRP onto GPVI. A. Side view of the surface of D1, illustrating the predicted binding of CRP within the binding groove. Two distinct docking algorithms placed CRP within the groove in D1 adjacent to the C′E region. B. Model of the GPVI-CRP complex predicted by the Patchdock and FTDock algorithms. The docking prediction for CRP determined by each program is shown with the C′E loop labeled for reference. Three crystal structures of CRP variants with their PDB IDs are illustrated above the predicted GPVI-CRP complex to show that the spacing and orientation of the docked CRP triple helices match the conserved ˜14 Angstrom spacing observed in the CRP crystal structures, which itself is similar to that observed in intact collagen fibers. Of note, although collagen fibers have circular cross-sections, within a blood vessel the average fiber diameter is very large (˜300-400 Angstroms) relative to the spacing between individual collagen triple helices (˜14 Angstroms), such that the surface recognized by GPVI would be approximately planar. C. Electrostatic potential of GPVI D1 mapped onto its surface, with the Patchdock CRP model superimposed. D. Stereo view of the residues in D1 that contact CRP in one or both of the docked models. The GPVI side chains contacting CRP are listed in the adjacent table according to their chemical properties of being hydrophobic, polar, and positively charged. E. Residues implicated in collagen or CRP binding are shown on the GPVI D1 surface after adding a modeled N-glycan. Darkly shaded residues (V34, K41, K59, and N-glycan) have been implicated in both collagen and CRP binding (O'Connor et al. J Thromb Haemost. 2005, Smethurst et al. Blood., 2004, Lecut et al. J Biol Chem., 2004, Kunicki et al. Blood. 2005), and moderately shaded residues (L36, R60, R166) have been implicated in collagen binding only (O'Connor et al. J Thromb Haemost. 2005, and Lecut et al. J Biol Chem. 2004).

FIG. 5. Implications for GPVI signaling. Model for signaling by receptor clustering, in which clustering triggers a signaling cascade via the FcR γ-chain co-receptor. This would resemble TCR signaling via the related ζ-chain co-receptor, which occurs upon clustering at least two TCR complexes in an orientation-independent manner, with the proximity of the TCR complexes correlating to the strength of the signal (Cochran et al. J Biol Chem. 2001). An individual GPVI dimer would not necessarily allow the γ-chains to approach closely enough to trigger signaling, due to the long GPVI stalk region. However, multiple GPVI molecules bound to a collagen fiber would bring several γ-chains into close proximity, triggering activation. Although GPVI in the model is illustrated as a dimer, the proposed mechanism of GPVI clustering by fibrous collagen would also apply if GPVI were monomeric at the platelet surface.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

The following abbreviations apply throughout this disclosure: GPVI, glycoprotein VI; Ig, immunoglobulin; LRC, leukocyte receptor cluster; CRP, collagen-related peptide; CBD, collagen-binding domain; polyproline type II, PPII. The atomic coordinates set forth in Table 2 have been deposited at the RCSB protein data bank (PDB 2GI7).

Activation of circulating platelets by exposed vessel wall collagen is a primary step in the pathogenesis of heart attack and stroke, and drugs to block platelet activation have successfully reduced cardiovascular morbidity and mortality. Platelet interaction with a damaged vessel wall initiates thrombus formation. Collagen is the primary component of the subendothelial matrix permitting platelet adhesion and activation. In humans and mice, collagen activation of platelets is mediated by glycoprotein VI (GPVI), a receptor that is homologous to immune receptors but bears little sequence similarity to known matrix protein adhesion receptors.

The receptor GPVI is central to the process of collagen-mediated platelet activation and subsequent thrombus formation. The atomic structure of GPVI is therefore of interest in terms of understanding how an immune-type receptor can recognize fibrous collagen. Furthermore, the structure allows the identification of potential regions responsible for interacting with collagen, which may serve as desirable targets for inhibitory drugs. The present invention provides a crystalline structure of the GPVI collagen binding domain, and the crystallographic data presently disclosed reveals that the GPVI CBD adopts a fold previously seen in related immune receptors of the leukocyte receptor cluster, but an 11-residue deletion in the sequence of GPVI relative to other LRC receptors creates a shallow groove on the surface of D1 that forms a putative collagen-binding site, based on docking algorithms and mutagenesis data.

The CBD forms a back-to-back dimer in the crystal in which the two putative collagen-binding grooves are nearly parallel and separated by 55 Angstroms, a configuration that matches the orientation and dimensions of triple helices within fibrous collagen. The dimeric GPVI conformation observed in the crystal is intriguing and may well represent the physiologically relevant form of GPVI on the platelet surface. Previous studies have shown that soluble GPVI-Fc fusions, but not monomeric soluble GPVI, inhibited platelet activation, suggesting that either a dimeric conformation or the higher avidity conferred by the Fc fusion was required to effectively compete with cell-surface GPVI for binding to collagen. This is further supported by surface plasmon resonance assays showing that the GPVI-Fc fusion bound collagen nearly 200-fold more tightly than monomeric GPVI did (Miura et al. J Biol Chem. (2002)).

The data presented herein suggest that GPVI dimerization is a rather weak interaction that nonetheless could occur on the platelet surface. Analytical ultracentrifugation experiments indicated that the soluble GPVI CBD construct used for crystallization remained monomeric in solution at up to 100 μM (FIG. 3A and data not shown). However, the construct crystallized according to the present invention lacks the stalk region, which could help stabilize a dimeric conformation, as seen for CD94 (Boyington et al. Protein Expr Purif. (2000)). Furthermore, the high density of GPVI at the platelet surface favors dimer formation. It is well established that weak protein-protein interactions in solution occur to a significant extent when the components are restricted to two-dimensional diffusion in a lipid bilayer. For example, if the K_(D) for GPVI dimerization in solution were 420 μM (˜8.5 mg/ml), this would correspond to a 2D K_(D) of 1260 receptors per μm², which is equivalent to the GPVI density on platelets. Thus even very weak dimerization of the CBD in solution would be sufficient to allow significant dimerization of GPVI at the platelet surface. Interestingly, activation of GPVI signaling by collagen is critically dependent on GPVI surface density; RBL cells transfected with GPVI were unresponsive to collagen unless expressed at a surface density approximating that observed on platelets (Zheng et al. J Biol Chem. (2001), Chen et al. J Biol Chem. (2002)). These studies, like the inhibition studies using GPVI-Fc fusion proteins, suggest that increased avidity of GPVI—or potentially the dimeric GPVI conformation described here—are required for effective interaction with collagen.

These present invention establishes a structural basis for the ability of platelets to recognize and be activated by the vessel wall matrix protein collagen. Platelet activation is a critical step in the pathogenesis of human vascular diseases and new anti-platelet agents have revolutionized the immediate treatment of myocardial infarction. The early role of GPVI in arterial thrombus formation and the relative lack of bleeding associated with human GPVI-deficiency states suggest that new therapies aimed at inhibiting GPVI function might provide an ideal long-term treatment approach to these diseases. A structural understanding of collagen recognition by GPVI provides a foundation for the development of novel therapeutic agents.

One embodiment of the present invention is directed to a crystal comprising the collagen binding domain of human GPVI having an amino acid sequence substantially similar to the sequence designated SEQ ID NO: 1. The crystal diffracts X-rays for determination of atomic coordinates to provide resolution of better than about 5.0 Angstroms. In more specific embodiments, the crystal diffracts to provide resolution of better than about 3 Angstroms or better than about 2.4 Angstroms. According to one embodiment, the GPVI collagen binding domain of the novel crystal is in a dimeric form.

A person of ordinary skill in the art understands that the amino acid sequence of the collagen binding domain designated as SEQ ID NO: 1 may comprise certain deletions, additions, mutations, or other differences and still retain substantive functionality. As used herein, therefore, the term “substantially similar” is intended to encompass sequences that encode polypeptides that retain structure and functionality, regardless of the presence of mutations. An amino acid sequence may, for example, differ from that set forth as SEQ ID NO: 1 by conservative substitutions and still be within the scope contemplated by reference to SEQ ID NO: 1. For purposes of defining the scope of the present invention, “conservative substitution” is used herein to mean amino acid substitutions which are functionally equivalent to the substituted amino acid residue. The substitution may have similar polarity, steric arrangement, or belong to the same class (e.g.: the nonpolar (hydrophobic) amino acids include alanine, glycine, leucine, isoleucine, valine, proline, phenylalanine, tryptophan and methionine; amino acids containing aromatic ring structures are phenylalanine, tryptophan, and tyrosine; the polar neutral amino acids include serine, threonine, cysteine, tyrosine, asparagine, and glutamine; the positively charged (basic) amino acids include arginine, lysine, and histidine; the negatively charged (acidic) amino acids include aspartic acid and glutamic acid) as the substituted residue, and includes substitutions that have an inconsequential effect on the three dimensional structure of GPVI with respect to the use of that structure for the design and/or selection of agents which interact with GPVI, as well as other proteins, peptides, molecules or molecular complexes comprising a substrate binding site, for molecular docking or computer modeling.

In another specific embodiment, the inventive crystal has an orthorhombic space group symmetry P2₁2₁2 and unit cell dimensions of a=114.06 Angstroms b=45.29 Angstroms, and c=75.13 Angstroms, with a unit cell variability of 5% in all dimensions. A unit cell of a crystal is the smallest divisible unit of the crystal that possesses the symmetry and properties of the crystal. It is a group of atoms that have a fixed geometry relative to one another. The unit cell is a “box” arrangement repeated by simple translation to make up the crystal where the atoms of the crystal may be at the corners, edges, on the faces or enclosed in the box giving the crystal its ordered internal arrangement.

According to another specific embodiment, the crystal comprises main chain and side chain atoms having a three dimensional structure defined by structural coordinates, which are the atomic coordinates set forth in Table 2. Structural coordinates, as used herein, refers to the Cartesian coordinates corresponding to an atom's spatial relationship to other atoms in a molecule or molecular complex. The coordinates are derived from mathematical equations related to the experimentally measured intensities obtained upon diffraction of a mono- or polychromatic beam of X-rays by the atoms (scattering centers) of a crystal. The diffraction data may be used to calculate an electron density map of the repeating unit of the crystal. The electron density maps can be used to establish the positions of the individual atoms within the unit cell of the crystal. Alternatively, computer programs such as CNS can be used to establish and refine the positions of individual atoms. Software programs are known in the art which permit graphical representation of a set of structural coordinates in order to obtain a three dimensional representation of a molecule or molecular complex. The structural coordinates of the present invention may be modified from the original sets provided Table 2 by, for example, various algebraic manipulations. Structural coordinates according to the present invention are relative, and are in no way specifically limited by the actual x, y, z coordinates set forth in Table 2. Those of skill in the art understand that a set of structure coordinates determined by X-ray crystallography has a degree of error. For the purposes of the invention, any set of structure coordinates having a root mean square deviation of equivalent protein main chain atoms (N, CA, C and O) of less than about 3.0 Angstroms or, more specifically less than about 2.0 Angstroms, 1.0 Angstroms, and 0.50 Angstroms, when superimposed, using main chain atoms, on the structure coordinates listed herein shall be considered within the scope of the invention.

As used herein, root mean square deviation refers to a statistical term defined as the square root of the arithmetic mean of the squares of the deviations from the mean. It represents deviation or variation from the structural coordinates set forth. The present invention is contemplated as including within its scope all embodiments comprising conservative substitutions of the noted amino acid residues resulting in the same structural coordinates within the stated root mean square deviation. It will be obvious to the skilled practitioner that the numbering of the amino acid residues may be different than that set forth herein, and may contain certain conservative amino acid substitutions that yield the same three dimensional structures as that defined by the Figures. Corresponding amino acids and conservative substitutions in other isoforms or analogues are easily identified by visual inspection of the relevant amino acid sequences or by using commercially available homology software programs (e.g., MODELLER, MSI, San Diego, Calif.) A person of skill in the art will recognize that the atomic coordinates set forth in Table 2, herein, may be encoded on a computer readable storage device or article. The data may be uploaded into a computer device and used to perform computer modeling using various computer drug design software products known in the art.

One method of screening a compound library or database that is useful for certain aspects of the present invention employs the well-known technique of molecular docking. “Docking” refers to placing candidate molecules from a library into the active site of the protein and evaluating how well the compound “fits” to the receptor or enzyme. Docking involves determinations of how best to fit the potential ligands into the active site, and how to rank the “fitting” of the compounds in the library in order to conduct meaningful comparisons. Algorithms and hardware are known in the art which permit docking with a consideration of conformation flexibility. “Virtual screening” is a term understood in the art to refer to computational processes that select molecules likely to have activity against a known biological target. Docking is a form of virtual screening since the molecules identified by a docking scan are compared directly with the requirements of the target.

Numerous computer programs are available and suitable for computer aided drug design, computer modeling, molecular docking, and computationally designing, identifying, selecting and evaluating potential inhibitors via computer programs according to the present invention. Known exemplary computer software designed for computer aided drug design include, but are not limited to, GRID (available from Oxford University, UK), MCSS (available from Molecular Simulations Inc., Burlington, Mass.), AUTODOCK (available from Oxford Molecular Group), FLEX X (available from Tripos, St. Louis. Mo.), DOCK (available from University of California, San Francisco), CAVEAT (available from University of California, Berkeley), HOOK (available from Molecular Simulations Inc., Burlington, Mass.), and 3D database systems such as MACCS-3D (available from MDL Information Systems, San Leandro, Calif.), UNITY (available from Tripos, St. Louis. Mo.), and CATALYST (available from Molecular Simulations Inc., Burlington, Mass.). Any of these software systems may be suitably employed in the presently inventive methods. Software including LUDI (available from Biosym Technologies, San Diego, Calif.), LEGEND (available from Molecular Simulations Inc., Burlington, Mass.), and LEAPFROG (Tripos Associates, St. Louis, Mo.), enable the ground-up synthesis of potential inhibitors rather than a means to screen existing molecules. Compound deformation energy and electrostatic repulsion, may be evaluated using programs such as GAUSSIAN 92, AMBER, QUANTA/CHARMM, AND INSIGHT II/DISCOVER. These computer modeling techniques may be performed on any suitable hardware including for example, workstations available from Silicon Graphics, Sun Microsystems, and the like. Other modeling techniques known in the art may also be employed in accordance with this invention. See for example, N.C. Cohen, Molecular Modeling in Drug Design, Academic Press (1996) (and references therein), and software identified at internet sites including the CMBI Cheminformatics site and the NIH Molecular Modeling site.

Another embodiment of the present invention provides a method of identifying an inhibitor of GPVI collagen binding activity. The method comprises: (1) designing or selecting a potential inhibitor using a three-dimensional structure of the GPVI collagen binding domain comprising main chain and atoms and as defined by atomic coordinates set forth in Table 2, plus or minus a root mean square deviation for the main chain atoms of not greater than 3 Angstroms; (2) synthesizing or obtaining the potential inhibitor; and (3) determining whether the potential inhibitor inhibits the activity of GPVI, wherein designing or selecting a potential inhibitor employs computer modeling. Various assays known in the art, including, but not limited to, protein binding assays, inhibitor assays and cellular-based assays, may be employed to determine whether the potential inhibitor inhibits the activity of GPVI. In some embodiments, determining whether the potential inhibitor inhibits the activity of GPVI comprises contacting the potential inhibitor with GPVI in the presence of a known ligand, determining the ability of the potential inhibitor to compete with the known GPVI collagen binding domain ligand and screening the potential inhibitor of GPVI in an assay for efficacy in inhibiting GPVI. Exemplary known ligands include collagen, CRP and convulxin.

In a further method embodiment, the atomic coordinates set forth in Table 2 may be used to design or select binding agents to interact with the GPVI collagen binding domain, employing, for example, any of the software products designed for computer aided drug design set forth above. Other embodiments are directed to methods of screening a library of compounds for potential to bind to the GPVI collagen binding domain. These methods comprise using at least some of the atomic coordinates set forth Table 2 to perform computational docking of the library of compounds to the GPVI collagen binding domain. Still other embodiments are directed to methods of identifying a compound useful for the treatment of a GPVI-mediated disorder. The methods comprise: (a) using a three-dimensional structure of the GPVI collagen binding domain as defined by at least some of the atomic coordinates set forth in Table 2, and (b) employing the structure to design, modify, or select a compound that modulates GPVI activity. GPVI modulators derived according to the present inventive methods may be useful in the prevention or treatment of vascular disorders, including, but not limited to thrombotic disorders.

Two specific agonists in addition to collagen are typically used to study GPVI function: collagen-related peptide (CRP), which is a class of triple helical synthetic peptides based on a repeated Glycine-Proline-Hydroxyproline (GPO) motif; and convulxin, a multimeric lectin-like toxin derived from rattlesnake venom. The GPVI structural data disclosed herein provides a framework for understanding the interaction between GPVI and collagen or CRP by allowing accurate mapping of mutagenesis results onto the surface of the GPVI dimer. The residues implicated in collagen or CRP binding fall into two clusters: the primary region includes basic residues on the surface of D1 including K41, K59, R60, and R166 (FIG. 4E). Mutation of K41 or K59 affects binding to both collagen and CRP; a K41A mutation increases the affinity of GPVI for both ligands, whereas mutation of residue K59 to the mouse equivalent (K59E) decreases affinity for both collagen and CRP. The R60A and R166A mutations reduce collagen affinity but have no effect on CRP binding. A second cluster of residues implicated in collagen or CRP binding is found at the distal end of D1; these residues include L36, implicated in collagen (but not CRP) binding, and both V34 and the N-glycan attached to N72, both of which are involved in collagen and CRP binding (Lecut et al. J Biol Chem. (2004), Kunicki et al. Blood. (2005)). The GPVI structure shows that the side chain of V34 is buried and its mutation is likely to alter the conformation of the BC loop in D1, which includes L36 and is immediately adjacent to N72.

In the presently disclosed computational model of CRP docked to GPVI, the CRP binding groove is located within the primary cluster of basic residues (K41, K59, R60, and R166). K41 is centrally positioned within the floor of the putative binding groove and contacts CRP directly. Furthermore, the docked CRP interacts with the side chain of R166 and is within reach of the K59 and R60 side chains. The docking predictions were based strictly on geometric and energetic criteria and did not take into account any mutagenesis data. Therefore, the correlation between the docking prediction and mutagenesis results suggests that the predicted CRP binding mode is a reasonable approximation of the physiological interaction of GPVI with CRP and collagen.

The cluster of residues including V34, L36 and the N-glycan at N72 may form a secondary binding site for CRP or collagen triple helices. Residue L36 is located on the surface of D1 approximately 14 Angstroms from the putative binding groove, and these secondary residues are positioned such that they could interact with adjacent triple helices within an intact collagen fibril. The mutagenesis results are therefore consistent with the mode of interaction between GPVI and a collagen fibril illustrated in FIG. 4B, in which a GPVI dimer binds simultaneously to several triple helices within the collagen fibril. This binding mode also suggests a model for the initiation of signal transduction triggered by receptor clustering that accompanies collagen binding (FIG. 5).

According to more specific embodiments of the present invention, the GPVI collagen binding domain comprises at least some or all of residues K41, S43, S44, R46, Q48, Q50, L53, F54, I55, P56, K59, S61, L62, Y66, and R166. Molecular docking-based modeling or computer aided drug design may be performed using the structural atomic coordinates of all or some of these specific residues. One may, for example, computationally dock a ligand to the binding site defined specifically by these residues, keep that binding site computationally locked, and delete any portion of the polypeptide remaining outside the locked coordinates. The computationally locked portion is then released and a fusion protein may be designed by fusing the released polypeptide to any other suitable polypeptide. Fusion proteins formed in this manner may be useful as GPVI modulators. According to this embodiment, the atomic coordinates of the subset of residues selected to define the binding site may vary by a root mean square deviation of not more than about 3.0 Angstroms, or, in more specific embodiments of not more than about 2.0, 1.0 and 0.5 Angstroms, and still be considered within the scope of the coordinates, regardless of the root mean square deviation of the main chain atoms of the entire fusion protein.

According to another specific embodiment, the dimeric form of the collagen binding domain is used to select or design agents via computer modeling or computer aided drug design according to the present invention, whereby two ligands for the binding site are designed or selected, wherein the two ligands may be the same or different, and are connected by a crosslinker of appropriate length to permit bivalent binding to the dimeric form of GPVI observed in the crystal.

The following Examples are provided to illustrate specific embodiments and aspects of the present invention and should not be construed as limiting the scope of the invention as defined by the claims.

Examples 1. Cloning, Expression, Refolding and Purification of GPVI.

Human GPVI cDNA was prepared as described in Zheng et al. J Biol Chem. (2001). The DNA sequence encoding the CBD (residues Q1-T183) was amplified by PCR using CACCGAAAACCTGTATTTTCAGGGCCAGAGTGGACCGCTCCCC SEQ ID NO: 3) (the tobacco etch virus protease (TEVp) cleavage site is underlined) and CTATGTGACCACAAGCTCCAGCGGGTCGCTGGG (SEQ ID NO: 4) as the sense and antisense primers, respectively. The PCR product was inserted into the pDEST17 vector encoding an N-terminal (His)₆-tag using the GATEWAY system (Invitrogen), and transformed into Escherichia coli strain Tuner(DE3) (Novagen). Cultures were grown to an A₆₀₀ of 0.8 and induced for 4 hours at 37° C. with 0.1 mM isopropyl β-D-thiogalactopyranoside. The recombinant GPVI CBD was solubilized from inclusion bodies using denaturant buffer (6 M guanidine hydrochloride, 20 mM NaH₂PO₄, 10 mM imidazole, 1 mM dithiothreitol, pH 7.3) and purified under denaturing conditions by immobilized-metal affinity chromatography (IMAC) using Ni-NTA agarose (QIAGEN).

The denatured and reduced protein was refolded by rapid dilution with vigorous stirring in refolding buffer (1 M L-arginine, 2 mM EDTA, 5 mM reduced L-glutathione, 0.5 mM oxidized L-glutathione and 100 mM Tris-HCl, pH 8.8) at 4° C. for 16 hours. The refolded protein was dialyzed against TEVp cleavage buffer (100 mM NaCl, 2 mM CaCl₂ and 20 mM Tris-HCl, pH 8.0), cleaved overnight at room temperature, and further purified by IMAC and size exclusion chromatography using a HiLoad™ 26/60 Superdex 75 column (Amersham Biosciences) equilibrated with TBS buffer (150 mM NaCl, 20 mM Tris-HCl, pH 7.4). The recombinant GPVI was judged to be >90% pure by SDS-PAGE with a yield of 0.5-1.0 mg per 1 L of LB. CRP used for binding experiments was purchased from Peptide International (Louisville, Ky.) as a non-crosslinked (POG)₁₀ polypeptide.

2. Crystallization and Structure Determination.

Purified GPVI was crystallized by mixing 0.4 μl GPVI (5 mg/ml in TBS) with 0.4 μl of crystallization buffer (1 M ammonium sulfate and 5% MPD) in sitting drop crystallization plates. Small needle-shaped crystals appeared in 3 days and were improved by micro- and macro-seeding techniques. For seeding, 2 μl of protein solution (10 mg/ml in TBS) was mixed with 2 μl of crystallization buffer (0.9 M ammonium sulfate, 8% MPD and 20% glycerol). After seeding, diamond-shaped plate-like crystals grew to a maximum size of ˜150×150×20 μm³ in one month. The crystals belong to the space group P2₁2₁2 with two GPVI molecules in the asymmetric unit. Data were collected at 110 K with an R-AXIS IV⁺⁺ image-plate area detector (Rigaku MSC) using CuKα radiation generated by a rotating anode generator (Micromax-007). A complete data set was collected to 2.4 Angstrom resolution from 176 images (0.5° oscillation with 5 minutes exposure time), processed by Mosflm, and scaled by SCALA from the CCP4 suite (Collaborative Computational Project No. 4. The CCP4 suite: programs for protein crystallography. Acta Crystallogr D. (1994)).

The structure was solved by molecular replacement using Phaser1.3.1 (McCoy et al. Acta Crystallogr D Biol Crystallogr. (2005)). The search model used was LIR-1 (pdb 1G0X (Chapman et al. Immunity (2000)) after truncating loops, which yielded two clear solutions. All crystallographic refinements were performed with CNS (Brunger et al. AT, Acta Crystallogr D Biol Crystallogr (1998)) using the maximum-likelihood target function. Rigid body refinement was followed by several cycles of torsion-angle simulated annealing, positional refinement, individual B-factor refinement, and manual model rebuilding. 2F_(o)-F_(c) and F_(o)-F_(c) electron density maps were used to manually rebuild the model with XtalView (McRee et al. J Struct Biol. (1999)). When the value of the R-factor dropped to 24%, solvent molecules and ions were gradually included. The electron density was well defined for the overall structure except for two residues of the N-terminus for molecule A and residues 99-107 and 130-137 for molecule B. The final model contained 182 and 167 residues for molecules A and B, respectively. Criteria for inclusion of solvent and ion molecules included height and shape of the electron density peaks and appropriate coordination by GPVI residues. Data collection and refinement statistics are reported in Table 1.

3. Analytical Ultracentrifugation.

Sedimentation velocity and equilibrium experiments were carried out at 20° C. in a Beckman XL-I ProteomeLab analytical ultracentrifuge using absorbance optics, as described in (Herr et al. J Mol Biol. (2003)). For sedimentation velocity experiments, samples of GPVI or mixtures with CRP were spun at 48,000 rpm. Sedimentation coefficients were determined using the program SEDFIT (Schuck et al. Biophys J. (2000)). For sedimentation equilibrium experiments, mixtures of 10 μM CRP and 10, 40, and 80 μM GPVI were spun at speeds of 16,000, 19,000, 29,000, 35,000, and 48,000 rpm. Data files were trimmed and analyzed by global fitting using the programs WinREEDIT and WinNONLIN (Jeff Lary, University of Connecticut, Storrs, Conn.). Values of s_(w), the weight-average sedimentation coefficient determined by SEDFIT, were fitted to a single-site binding isotherm using SEDPHAT (Schuck et al. Anal Biochem. (2003)).

4. Docking of CRP to GPVI.

The Patchdock server (Schneidman-Duhovny et al. Proteins (2003)) was used to predict the binding orientation of CRP on GPVI. A truncated CRP with the sequence (POG)₅ was created from the crystal structure of (POG)₄POA(POG)₅ (pdb 1CAG (Bella et al. Science (1994)) and used as the ligand, with GPVI D1 as the receptor. Six of the top 10 solutions showed CRP bound in a putative binding groove adjacent to the C′E loop and neighboring several residues implicated in collagen and CRP binding (K41, K59, R60, and R166 (O'Connor et al. J Thromb Haemost. (2005), Smethurst et al. Blood. (2004)). Three of these solutions bound in one orientation (i.e., with the N-termini of CRP closer to GPVI residue F54), and the other three solutions bound in the opposite orientation (i.e., with the C-termini closer to F54), consistent with the pseudo-two-fold symmetry within CRP.

The FTDock program from the 3D-Dock software package was also used to dock CRP to GPVI (Katchalski-Katzir et al. Proc Natl Acad Sci USA. (1992)). Because FTDock does not recognize hydroxyproline, a modified CRP with the sequence (PPG)₅ was created from the crystal structure of (PPG)₁₀, (pdb 1K6F (Berisio et al. Protein Sci. (2002)). The grid-based shape complementarity search was performed using 148 grid units in each dimension (grid point spacing: 0.7 Angstrom). The docking solutions were sorted by surface complementarity and the top solution was also found in the same surface groove in D1 identified by Patchdock. Furthermore, filtering the solutions by proximity to K59 reveals a second solution within the binding groove, but in the opposite orientation.

5. Calculation of Estimated 2D K_(D) at Platelet Surface.

Correlating the reported GPVI receptor density on the platelet surface (Chen et al. J Biol Chem. (2002)) with an estimated K_(D) for dimerization of soluble GPVI CBD was carried out according the approach of Dustin et al. (Dustin et al. J Cell Biol. (1996), Dustin et al. J Biol Chem. (1997)). The interaction of two membrane-embedded receptors is estimated to occur with a loss of 3 degrees of freedom (compared to their interaction as soluble receptors), due to their restriction to 2-dimensional diffusion within the plane of a lipid bilayer (Bromley et al. Nat Immunol. (2001)). The 3D K_(D) was converted into ΔG and corrected by a factor of −1.5RT to account for the 2D restriction of the receptors. The corrected 3D K_(D)* was then converted from molar units to receptors per μm³. Finally, the 2D K_(D) was estimated based on the equation 2D K_(D)=σ (3D K_(D)*), where σ is the confinement region corresponding to the distance the receptor extends outward from the membrane. For GPVI, the confinement region was calculated to be 22 nm by adding the height of the CBD (52 Angstroms) and the estimated height of the 65-residue O-glycosylated stalk (169 Angstroms, based on the reported dimensions of 2.6 Angstroms per residue for the O-glycosylated stalk of CD8 (Merry et al. J Biol Chem. (2003)).

6. Other Computational Methods.

Generation of collagen fiber models was carried out by applying crystallographic symmetry to the CRP structures (pdb 1CAG, 1CGD, and 1BKV) using the program O (Jones et al. Acta Crystallogr A. (1991)). Analysis of buried surface areas and interdomain angles were calculated using Areaimol from the CCP4 suite (Collaborative Computational Project No. 4. The CCP4 suite: programs for protein crystallography. Acta Crystallogr D. (1994), and Dom_Angle, respectively (Su et al. Science. (1998)). Domain boundaries were defined as residues 0-89 for D1 and residues 90-183 for D2. Figures were generated with PyMOL (DeLano et al. DeLano Scientific (2002), Molscript (Kraulis et al. J Appl Crystallogr. (1991), and Raster3D (Merritt et al. Acta Cryst D. (1994)).

7. Crystal Structure of the Collagen-Binding Domain of GPVI.

The crystal structure of the GPVI CBD was solved by molecular replacement using data to a resolution of 2.4 Angstroms. The CBD is composed of two Ig-like domains oriented 90° apart, similar to other LRC receptors such as FcαRI and the leukocyte Ig-like (LILR or LIR) and killer-cell Ig-like (KIR) receptor families (FIG. 1A, C). Both the N-terminal and C-terminal domains (D1 and D2, respectively) of GPVI most closely resemble the domains of p58 KIR (Fan et al. Nature (1997)), with rms deviations of 1.7 and 1.6 Angstroms over 83 and 82 residues, respectively. There were two GPVI molecules per asymmetric unit, with D1-D2 interdomain angles ranging from 90-92° and with D1-D2 interfaces that buried 855-877 square Angstroms. These interdomain angles and interface areas are comparable to those observed for FcαRI, LIR-1, and p58 KIR, although the interface area for GPVI is somewhat less extensive. As in many LRC receptors, a conserved cis proline in D1 (P14) introduces a bend after the first β strand, creating a distinct A′ strand that forms hydrogen bonds with the G strand. As a result, the Ig fold of D1 is I-type, formed by two β sheets composed of the ABE and A′GFCC′ strands. D1 also contains a short 3₁₀ helix and two stretches of polyproline type II (PPII) helix. Within D1, the most significant differences between GPVI and other LRC receptors occur in the C′ and E strands and intervening C′E loop, which adopt unusual conformations due to an 11-residue deletion in GPVI (FIG. 1B, D). This deletion creates a shallow, primarily hydrophobic groove on the surface of D1 bordered by charged and polar residues including K41, K59, R60, and R166, which have been implicated in collagen or CRP binding. There is a single predicted N-glycosylation site at residue N72 in the FG loop of D1; the N-glycan would be expected to extend outward from the end of D1, as seen for FcαRI (Herr et al. Nature (2003)).

GPVI D2, like D1, contains the conserved proline (P100) at the end of the A strand, but in D2 it adopts the trans rather than cis conformation. As a result, there is no sharp bend in the protein backbone, the A′ strand does not form, and the architecture of the subsequent AB loop is significantly altered (FIG. 1E). The topology of the D2 domain is therefore a C2-type Ig fold with ABE and GFCC′ β sheets, rather than the typical I-type fold. GPVI D2 diverges somewhat from the canonical C2 fold, which features a very short C′ strand of three residues. Instead, GPVI D2 has significantly elongated C and C′ strands, each containing 10 residues. Both the unusual AB loop and CC′ β hairpin extend outward from the main body of D2 and appear to be quite flexible, given the lack of clear electron density for these regions in a second independent molecule within the asymmetric unit.

8. The GPVI CBD Forms a Dimer in the Crystal.

The asymmetric unit of the crystal contains a parallel, back-to-back dimer formed by the D2 domains of the two GPVI molecules (FIG. 2A). The G strands of the D2 domains interact to create a continuous β sheet across the dimer interface. The unusual D2 architecture lacking an A′ strand is necessary for dimer formation, since the presence of A′ strands would sterically block the G strands from forming a continuous β sheet. The dimer interface buries 1,046 square Angstroms of accessible surface area, which is within the range expected for dimeric proteins, although lower than average for a protein of this size (Jones et al. Proc Natl Acad Sci USA. (1996)). The dimer interface shows excellent surface complementarity, with a shape complementarity index of 0.73, comparable to oligomeric proteins (S_(c)=0.70-0.74) and protease-inhibitor complexes (S_(c)=0.71-0.76) (Lawrence et al. J Mol Biol. (1993)). The interface is dominated by hydrophobic interactions along with hydrogen bonds contributed by the peptide backbone in the parallel G strands of both D2 domains (FIG. 2B). Interestingly, the GPVI dimerization mode is essentially identical to that observed for CD3εγ and CD3εδ receptor heterodimers in the T-cell receptor (TCR) complex (Sun et al. Cell (2001), Sun et al. Proc Natl Acad Sci USA. (2004), Kjer-Nielsen et al. Proc Natl Acad Sci USA. (2004)). Like GPVI, CD3εγ and CD3εδ form back-to-back dimers with the G strands forming a continuous β sheet (FIG. 2C). Indeed, the CD3εγ dimer (Kjer-Nielsen et al. Proc Natl Acad Sci USA. (2004)) superimposes on the GPVI D2 dimer with an rms deviation of only 2.0 Angstroms over 55 residues, which is remarkable given the low sequence identity between GPVI and the CD3 receptors (20% or 14% identity between GPVI and CD3ε or γ, respectively).

9. Interaction of GPVI CBD and Collagen-Related Peptide in Solution.

To understand how GPVI associates with the macromolecule collagen, the interactions between the GPVI, CBD and CRP, which functionally mimics collagen in biological assays, were studied. To analyze the affinity of the interaction under conditions favoring a 1:1 complex, sedimentation velocity analytical ultracentrifugation experiments were carried out by titrating GPVI with CRP (a non-crosslinked (POG)₁₀ triple helix) at up to 35-fold molar excess (FIG. 3A). The weight-averaged sedimentation coefficient (s_(w)) of each dataset was plotted as a function of CRP concentration and fitted to a single-site binding isotherm, yielding a K_(D) of 5 μM (FIG. 3A, inset). This affinity is significantly tighter than that determined by surface plasmon resonance (SPR) (Miura et al. J Biol Chem. (2002)); however, the SPR experiment measured binding of GPVI to immobilized, cross-linked CRP with a different sequence than the non-crosslinked CRP described here.

Additional sedimentation velocity and sedimentation equilibrium experiments conducted using 1:1, 4:1, or 8:1 molar ratios mixtures of GPVI:CRP indicated that multiple GPVI molecules can bind to a single CRP triple helix, consistent with the presence of multiple overlapping sites for GPVI within the repeating tripeptide sequence of the CRP triple helix. The s_(w) values indicated formation of a 1:1 complex in the first sample and formation of higher-order complexes in the 4:1 and 8:1 mixtures (FIG. 3B). Sedimentation equilibrium experiments conducted in parallel on similar mixtures indicated that two or three molecules of GPVI could bind simultaneously to a CRP triple helix (data not shown).

10. Computational Determination of CRP Binding Sites on the GPVI Dimer.

Unfortunately, complexes of GPVI with CRP were found to be resistant to crystallization, most likely due to excessive heterogeneity of the complexes, which results from the ability of GPVI to bind at multiple overlapping sites along the triple helix. In order to identify collagen-binding sites on GPVI, two different computational algorithms, PatchDock (Schneidman-Duhovny et al. Proteins (2003)) and FTDock (Katchalski-Katzir et al. Proc Natl Acad Sci USA. (1992)), were employed to dock CRP onto GPVI. Both docking programs positioned CRP within the shallow groove on D1 adjacent to the C′E loop (FIG. 4A, B). The floor of the putative binding groove is formed by several hydrophobic residues (L53, F54, P56, L62, and Y66 and the aliphatic portion of K41), with several polar (S43, S44, Q48, Q50, S61) and basic (K41, R46, K59, R166) residues around the periphery (FIG. 4C-E). This groove is unique to GPVI among LRC receptors, as it results from the 11-residue deletion in GPVI. The binding of CRP to this groove provides a structural explanation for how an immune-type receptor has evolved to bind vessel wall collagen. In these models, CRP is immediately adjacent to GPVI residues K41, K59, R60, and R166, which have been implicated as collagen and CRP-binding residues by mutational analysis, as described below (FIG. 4E). Furthermore, previously described GPVI mutations having no effect on CRP affinity are not located within the putative binding groove. The docked CRP solutions from each program are evenly distributed between two nearly opposite orientations within the groove. This is consistent with the pseudo-two fold symmetry present in CRP, caused by its imino groups (prolines and hydroxyprolines) occupying similar positions in both orientations.

Native collagen fibers are composed of a pseudo-hexagonal array of parallel CRP-like triple helices separated by 13-14 Angstroms, an arrangement that is also conserved in crystal structures of soluble CRP-like peptides (FIG. 4B, top). Interestingly, the two putative CRP-binding grooves within a GPVI dimer are essentially parallel and are separated by ˜55 Angstroms, which is equivalent to the distance between the n and n+4 helices in a collagen fiber. The geometric compatibility of the binding grooves with collagen helices would allow the GPVI dimer to bind simultaneously to two triple helices within a collagen fiber.

TABLE 1 Crystallographic data processing and refinement statistics Data Collection Wavelength (Angstroms) 1.5418 Space group P2₁2₁2 Cell dimensions (Angstroms) a = 114.06 b = 45.29 c = 75.13 Resolution range (Angstroms)* 20.0-2.4 (2.52-2.40) Measured reflections 50,335 Unique reflections 15,739 Average I/σ(I) 6.6 (2.1) Completeness (%) 99.3 (97.4) R_(sym) (%)^(†)  7.9 (34.8) Refinement statistics Resolution range used in refinement 10-2.4 (Angstroms) R factor (%)^(‡) 22.3 R_(free) (%)^(∥) 27.6 Number of heavy atoms Molecule A (Residues: 2-183) 1412 Molecule B (Residues: 0-98, 1309 108-129, 138-183) Water molecules 177 Glycerol (2), SO₄ ²⁻ (2), Cl⁻ (1) 23 Average B factor (square Angstroms) Molecule A 44.3 Molecule B 50.9 Solvent 51.3 Ramachandran plot Residues in most favored 252 Residues in additional allowed 33 Residues in generously allowed 1 Residues in disallowed 0 rms deviations from ideal Bond lengths (Angstroms) 0.006 Bond angles (°) 1.50 *Values in parentheses refer to the highest resolution shell. ^(†)R_(sym) = Σ_(i)|I_(hi) − <I_(hi)>|/Σ_(i)|I_(hi)|, where h specifies unique reflection indices, i indicates symmetry equivalent observations of h. ^(‡)R factor = Σ||F_(obs)| − |F_(calc)||/ |F_(obs)|, where |F_(obs)| and |F_(calc)| are the observed and calculated structure factor amplitudes, respectively. ^(∥)R_(free) is the same as R factor, but was calculated for a test set containing 5% randomly chosen reflections that were not included in the refinement.

TABLE 2 CRYST1 114.057    45.286  75.131  90.00  90.00   90.00  P 21 21 2 ATOM 1 N SER A 2 18.171 29.819 66.736 1.00 49.43 N ATOM 2 CA SER A 2 17.428 28.818 65.924 1.00 49.76 C ATOM 3 C SER A 2 18.155 28.559 64.607 1.00 48.33 C ATOM 4 O SER A 2 18.657 29.486 63.969 1.00 49.56 O ATOM 5 CB SER A 2 16.003 29.316 65.670 1.00 51.80 C ATOM 6 OG SER A 2 15.999 30.700 65.351 1.00 55.27 O ATOM 7 N GLY A 3 18.211 27.291 64.209 1.00 46.47 N ATOM 8 CA GLY A 3 18.905 26.917 62.990 1.00 43.11 C ATOM 9 C GLY A 3 18.191 27.192 61.678 1.00 41.71 C ATOM 10 O GLY A 3 17.077 27.719 61.662 1.00 40.69 O ATOM 11 N PRO A 4 18.830 26.843 60.548 1.00 39.53 N ATOM 12 CA PRO A 4 18.310 27.027 59.195 1.00 39.01 C ATOM 13 C PRO A 4 17.226 26.018 58.809 1.00 39.56 C ATOM 14 O PRO A 4 17.117 24.935 59.390 1.00 38.22 O ATOM 15 CB PRO A 4 19.560 26.906 58.333 1.00 38.63 C ATOM 16 CG PRO A 4 20.361 25.891 59.065 1.00 38.24 C ATOM 17 CD PRO A 4 20.211 26.324 60.507 1.00 38.96 C ATOM 18 N LEU A 5 16.444 26.391 57.804 1.00 39.25 N ATOM 19 CA LEU A 5 15.339 25.584 57.308 1.00 40.47 C ATOM 20 C LEU A 5 15.742 24.657 56.166 1.00 40.51 C ATOM 21 O LEU A 5 16.743 24.881 55.494 1.00 42.63 O ATOM 22 CB LEU A 5 14.223 26.521 56.830 1.00 40.35 C ATOM 23 CG LEU A 5 13.756 27.536 57.876 1.00 39.58 C ATOM 24 CD1 LEU A 5 12.845 28.585 57.259 1.00 39.37 C ATOM 25 CD2 LEU A 5 13.040 26.789 58.978 1.00 40.29 C ATOM 26 N PRO A 6 14.963 23.595 55.930 1.00 40.62 N ATOM 27 CA PRO A 6 15.317 22.689 54.835 1.00 39.86 C ATOM 28 C PRO A 6 15.379 23.426 53.487 1.00 39.04 C ATOM 29 O PRO A 6 14.706 24.433 53.290 1.00 38.95 O ATOM 30 CB PRO A 6 14.221 21.618 54.904 1.00 40.12 C ATOM 31 CG PRO A 6 13.089 22.302 55.615 1.00 40.90 C ATOM 32 CD PRO A 6 13.782 23.110 56.662 1.00 39.95 C ATOM 33 N LYS A 7 16.204 22.939 52.565 1.00 38.90 N ATOM 34 CA LYS A 7 16.343 23.595 51.266 1.00 36.61 C ATOM 35 C LYS A 7 15.151 23.348 50.354 1.00 34.96 C ATOM 36 O LYS A 7 14.530 22.283 50.381 1.00 35.59 O ATOM 37 CB LYS A 7 17.618 23.126 50.553 1.00 36.94 C ATOM 38 CG LYS A 7 17.486 21.786 49.868 1.00 36.31 C ATOM 39 CD LYS A 7 18.829 21.249 49.433 1.00 38.26 C ATOM 40 CE LYS A 7 18.681 19.824 48.931 1.00 39.11 C ATOM 41 NZ LYS A 7 19.998 19.151 48.737 1.00 45.99 N ATOM 42 N PRO A 8 14.834 24.331 49.510 1.00 32.67 N ATOM 43 CA PRO A 8 13.711 24.208 48.587 1.00 30.96 C ATOM 44 C PRO A 8 14.149 23.476 47.329 1.00 34.27 C ATOM 45 O PRO A 8 15.331 23.198 47.131 1.00 33.75 O ATOM 46 CB PRO A 8 13.362 25.649 48.301 1.00 29.43 C ATOM 47 CG PRO A 8 14.753 26.282 48.216 1.00 32.03 C ATOM 48 CD PRO A 8 15.515 25.632 49.359 1.00 29.78 C ATOM 49 N SER A 9 13.188 23.163 46.477 1.00 34.49 N ATOM 50 CA SER A 9 13.500 22.493 45.241 1.00 34.88 C ATOM 51 C SER A 9 13.551 23.600 44.202 1.00 35.14 C ATOM 52 O SER A 9 12.967 24.670 44.391 1.00 34.19 O ATOM 53 CB SER A 9 12.396 21.486 44.889 1.00 37.58 C ATOM 54 OG SER A 9 11.145 22.141 44.701 1.00 37.99 O ATOM 55 N LEU A 10 14.271 23.352 43.118 1.00 34.40 N ATOM 56 CA LEU A 10 14.363 24.314 42.038 1.00 35.58 C ATOM 57 C LEU A 10 14.329 23.476 40.779 1.00 36.49 C ATOM 58 O LEU A 10 15.282 22.763 40.473 1.00 39.59 O ATOM 59 CB LEU A 10 15.660 25.117 42.127 1.00 32.11 C ATOM 60 CG LEU A 10 15.820 26.207 41.066 1.00 29.39 C ATOM 61 CD1 LEU A 10 14.567 27.065 41.005 1.00 29.82 C ATOM 62 CD2 LEU A 10 17.047 27.055 41.383 1.00 30.57 C ATOM 63 N GLN A 11 13.221 23.558 40.056 1.00 38.36 N ATOM 64 CA GLN A 11 13.043 22.759 38.854 1.00 40.01 C ATOM 65 C GLN A 11 12.611 23.583 37.645 1.00 38.19 C ATOM 66 O GLN A 11 11.903 24.577 37.780 1.00 37.77 O ATOM 67 CB GLN A 11 12.031 21.653 39.167 1.00 42.44 C ATOM 68 CG GLN A 11 12.401 20.910 40.455 1.00 49.56 C ATOM 69 CD GLN A 11 11.405 19.829 40.866 1.00 55.23 C ATOM 70 OE1 GLN A 11 10.201 20.083 40.988 1.00 57.58 O ATOM 71 NE2 GLN A 11 11.912 18.618 41.104 1.00 55.37 N ATOM 72 N ALA A 12 13.072 23.182 36.465 1.00 36.79 N ATOM 73 CA ALA A 12 12.732 23.879 35.232 1.00 35.95 C ATOM 74 C ALA A 12 11.693 23.044 34.491 1.00 36.46 C ATOM 75 O ALA A 12 11.715 21.813 34.581 1.00 36.19 O ATOM 76 CB ALA A 12 13.983 24.062 34.371 1.00 33.53 C ATOM 77 N LEU A 13 10.788 23.708 33.771 1.00 36.07 N ATOM 78 CA LEU A 13 9.735 23.017 33.026 1.00 36.02 C ATOM 79 C LEU A 13 9.375 23.702 31.710 1.00 37.40 C ATOM 80 O LEU A 13 9.337 24.933 31.624 1.00 40.32 O ATOM 81 CB LEU A 13 8.474 22.880 33.881 1.00 35.04 C ATOM 82 CG LEU A 13 8.463 21.787 34.948 1.00 34.87 C ATOM 83 CD1 LEU A 13 7.179 21.862 35.761 1.00 34.39 C ATOM 84 CD2 LEU A 13 8.585 20.428 34.272 1.00 35.61 C ATOM 85 N PRO A 14 9.083 22.906 30.666 1.00 36.36 N ATOM 86 CA PRO A 14 9.082 21.435 30.705 1.00 36.31 C ATOM 87 C PRO A 14 10.443 20.750 30.963 1.00 36.47 C ATOM 88 O PRO A 14 10.489 19.613 31.441 1.00 35.62 O ATOM 89 CB PRO A 14 8.475 21.062 29.353 1.00 35.66 C ATOM 90 CG PRO A 14 8.946 22.178 28.455 1.00 35.35 C ATOM 91 CD PRO A 14 8.760 23.404 29.317 1.00 35.80 C ATOM 92 N SER A 15 11.543 21.439 30.669 1.00 35.85 N ATOM 93 CA SER A 15 12.869 20.860 30.878 1.00 36.71 C ATOM 94 C SER A 15 13.958 21.895 31.182 1.00 36.67 C ATOM 95 O SER A 15 13.795 23.084 30.911 1.00 36.15 O ATOM 96 CB SER A 15 13.275 20.057 29.634 1.00 36.92 C ATOM 97 OG SER A 15 14.626 19.625 29.703 1.00 38.10 O ATOM 98 N SER A 16 15.073 21.430 31.741 1.00 36.81 N ATOM 99 CA SER A 16 16.198 22.311 32.041 1.00 37.01 C ATOM 100 C SER A 16 17.031 22.454 30.769 1.00 37.99 C ATOM 101 O SER A 16 17.932 23.294 30.682 1.00 37.37 O ATOM 102 CB SER A 16 17.046 21.730 33.170 1.00 37.32 C ATOM 103 OG SER A 16 17.429 20.410 32.865 1.00 40.96 O ATOM 104 N LEU A 17 16.733 21.606 29.787 1.00 39.64 N ATOM 105 CA LEU A 17 17.405 21.665 28.492 1.00 41.01 C ATOM 106 C LEU A 17 16.420 22.410 27.606 1.00 40.76 C ATOM 107 O LEU A 17 15.349 21.894 27.265 1.00 40.45 O ATOM 108 CB LEU A 17 17.661 20.269 27.923 1.00 42.49 C ATOM 109 CG LEU A 17 18.708 19.407 28.630 1.00 45.34 C ATOM 110 CD1 LEU A 17 18.971 18.178 27.792 1.00 44.53 C ATOM 111 CD2 LEU A 17 19.996 20.188 28.832 1.00 44.60 C ATOM 112 N VAL A 18 16.779 23.631 27.247 1.00 40.13 N ATOM 113 CA VAL A 18 15.897 24.454 26.444 1.00 39.21 C ATOM 114 C VAL A 18 16.491 24.888 25.127 1.00 38.82 C ATOM 115 O VAL A 18 17.560 25.503 25.085 1.00 36.71 O ATOM 116 CB VAL A 18 15.500 25.741 27.195 1.00 39.72 C ATOM 117 CG1 VAL A 18 14.308 26.409 26.488 1.00 40.26 C ATOM 118 CG2 VAL A 18 15.202 25.428 28.660 1.00 39.06 C ATOM 119 N PRO A 19 15.813 24.551 24.024 1.00 40.10 N ATOM 120 CA PRO A 19 16.339 24.968 22.723 1.00 41.53 C ATOM 121 C PRO A 19 16.079 26.472 22.567 1.00 42.12 C ATOM 122 O PRO A 19 15.038 26.974 23.002 1.00 42.23 O ATOM 123 CB PRO A 19 15.558 24.097 21.733 1.00 39.86 C ATOM 124 CG PRO A 19 14.330 23.729 22.465 1.00 39.66 C ATOM 125 CD PRO A 19 14.780 23.513 23.873 1.00 39.16 C ATOM 126 N LEU A 20 17.041 27.191 21.996 1.00 42.89 N ATOM 127 CA LEU A 20 16.905 28.632 21.808 1.00 44.13 C ATOM 128 C LEU A 20 15.560 28.964 21.189 1.00 46.58 C ATOM 129 O LEU A 20 15.047 28.201 20.372 1.00 46.40 O ATOM 130 CB LEU A 20 18.024 29.155 20.912 1.00 44.08 C ATOM 131 CG LEU A 20 19.419 29.101 21.536 1.00 44.71 C ATOM 132 CD1 LEU A 20 20.477 29.347 20.478 1.00 42.64 C ATOM 133 CD2 LEU A 20 19.506 30.132 22.652 1.00 44.19 C ATOM 134 N GLU A 21 14.995 30.104 21.585 1.00 48.92 N ATOM 135 CA GLU A 21 13.695 30.552 21.081 1.00 50.54 C ATOM 136 C GLU A 21 12.540 29.852 21.790 1.00 49.68 C ATOM 137 O GLU A 21 11.403 30.314 21.727 1.00 49.37 O ATOM 138 CB GLU A 21 13.588 30.310 19.568 1.00 52.65 C ATOM 139 CG GLU A 21 14.000 31.484 18.684 1.00 58.03 C ATOM 140 CD GLU A 21 15.235 32.228 19.185 1.00 62.13 C ATOM 141 OE1 GLU A 21 15.123 32.958 20.199 1.00 63.55 O ATOM 142 OE2 GLU A 21 16.316 32.086 18.565 1.00 63.56 O ATOM 143 N LYS A 22 12.828 28.743 22.466 1.00 48.20 N ATOM 144 CA LYS A 22 11.784 28.010 23.172 1.00 47.26 C ATOM 145 C LYS A 22 11.614 28.504 24.603 1.00 47.34 C ATOM 146 O LYS A 22 12.518 29.120 25.171 1.00 47.20 O ATOM 147 CB LYS A 22 12.096 26.517 23.155 1.00 48.86 C ATOM 148 CG LYS A 22 12.199 25.945 21.756 1.00 49.81 C ATOM 149 CD LYS A 22 10.898 26.118 21.002 1.00 52.62 C ATOM 150 CE LYS A 22 10.953 25.480 19.622 1.00 54.06 C ATOM 151 NZ LYS A 22 9.655 25.654 18.903 1.00 56.10 N ATOM 152 N PRO A 23 10.444 28.244 25.208 1.00 46.88 N ATOM 153 CA PRO A 23 10.167 28.680 26.581 1.00 46.01 C ATOM 154 C PRO A 23 10.570 27.714 27.696 1.00 45.25 C ATOM 155 O PRO A 23 10.641 26.495 27.495 1.00 43.07 O ATOM 156 CB PRO A 23 8.662 28.905 26.563 1.00 45.81 C ATOM 157 CG PRO A 23 8.204 27.760 25.728 1.00 47.25 C ATOM 158 CD PRO A 23 9.209 27.759 24.564 1.00 46.65 C ATOM 159 N VAL A 24 10.824 28.291 28.872 1.00 43.43 N ATOM 160 CA VAL A 24 11.187 27.544 30.068 1.00 40.67 C ATOM 161 C VAL A 24 10.838 28.377 31.292 1.00 39.39 C ATOM 162 O VAL A 24 11.071 29.583 31.323 1.00 39.49 O ATOM 163 CB VAL A 24 12.711 27.183 30.106 1.00 39.78 C ATOM 164 CG1 VAL A 24 13.571 28.443 30.027 1.00 38.40 C ATOM 165 CG2 VAL A 24 13.020 26.408 31.380 1.00 34.09 C ATOM 166 N THR A 25 10.263 27.725 32.293 1.00 38.24 N ATOM 167 CA THR A 25 9.892 28.399 33.524 1.00 38.20 C ATOM 168 C THR A 25 10.545 27.729 34.735 1.00 38.61 C ATOM 169 O THR A 25 10.428 26.520 34.923 1.00 38.06 O ATOM 170 CB THR A 25 8.357 28.429 33.709 1.00 37.31 C ATOM 171 OG1 THR A 25 8.049 28.601 35.097 1.00 38.56 O ATOM 172 CG2 THR A 25 7.729 27.150 33.212 1.00 35.98 C ATOM 173 N LEU A 26 11.244 28.529 35.538 1.00 38.95 N ATOM 174 CA LEU A 26 11.922 28.036 36.728 1.00 40.70 C ATOM 175 C LEU A 26 11.023 28.236 37.937 1.00 41.86 C ATOM 176 O LEU A 26 10.373 29.270 38.084 1.00 42.93 O ATOM 177 CB LEU A 26 13.253 28.771 36.941 1.00 38.62 C ATOM 178 CG LEU A 26 14.187 28.879 35.730 1.00 38.76 C ATOM 179 CD1 LEU A 26 15.574 29.324 36.182 1.00 38.28 C ATOM 180 CD2 LEU A 26 14.272 27.547 35.033 1.00 38.07 C ATOM 181 N ARG A 27 10.999 27.244 38.814 1.00 42.50 N ATOM 182 CA ARG A 27 10.157 27.320 39.986 1.00 43.14 C ATOM 183 C ARG A 27 10.897 26.915 41.253 1.00 42.14 C ATOM 184 O ARG A 27 11.492 25.836 41.316 1.00 40.72 O ATOM 185 CB ARG A 27 8.943 26.409 39.794 1.00 46.31 C ATOM 186 CG ARG A 27 7.846 26.573 40.837 1.00 52.43 C ATOM 187 CD ARG A 27 6.581 27.132 40.188 1.00 58.55 C ATOM 188 NE ARG A 27 5.466 27.236 41.125 1.00 63.04 N ATOM 189 CZ ARG A 27 4.239 27.631 40.788 1.00 65.77 C ATOM 190 NH1 ARG A 27 3.963 27.964 39.531 1.00 65.24 N ATOM 191 NH2 ARG A 27 3.283 27.687 41.709 1.00 66.11 N ATOM 192 N CYS A 28 10.861 27.790 42.256 1.00 40.19 N ATOM 193 CA CYS A 28 11.480 27.503 43.541 1.00 41.99 C ATOM 194 C CYS A 28 10.323 27.006 44.413 1.00 42.73 C ATOM 195 O CYS A 28 9.216 27.535 44.328 1.00 45.70 O ATOM 196 CB CYS A 28 12.098 28.773 44.125 1.00 40.17 C ATOM 197 SG CYS A 28 13.155 28.487 45.581 1.00 41.89 S ATOM 198 N GLN A 29 10.547 25.984 45.230 1.00 42.82 N ATOM 199 CA GLN A 29 9.461 25.478 46.063 1.00 43.47 C ATOM 200 C GLN A 29 9.940 24.905 47.381 1.00 43.85 C ATOM 201 O GLN A 29 10.655 23.904 47.409 1.00 45.20 O ATOM 202 CB GLN A 29 8.670 24.403 45.311 1.00 44.89 C ATOM 203 CG GLN A 29 7.389 23.969 46.013 1.00 45.62 C ATOM 204 CD GLN A 29 6.262 24.994 45.872 1.00 47.19 C ATOM 205 OE1 GLN A 29 5.669 25.140 44.801 1.00 48.71 O ATOM 206 NE2 GLN A 29 5.971 25.711 46.956 1.00 47.18 N ATOM 207 N GLY A 30 9.539 25.545 48.474 1.00 44.09 N ATOM 208 CA GLY A 30 9.928 25.075 49.791 1.00 44.88 C ATOM 209 C GLY A 30 8.674 24.699 50.551 1.00 46.67 C ATOM 210 O GLY A 30 7.590 24.713 49.967 1.00 47.06 O ATOM 211 N PRO A 31 8.774 24.370 51.851 1.00 46.66 N ATOM 212 CA PRO A 31 7.582 24.001 52.627 1.00 45.84 C ATOM 213 C PRO A 31 6.437 25.017 52.513 1.00 43.97 C ATOM 214 O PRO A 31 6.638 26.166 52.120 1.00 40.31 O ATOM 215 CB PRO A 31 8.121 23.875 54.054 1.00 45.53 C ATOM 216 CG PRO A 31 9.310 24.791 54.060 1.00 46.87 C ATOM 217 CD PRO A 31 9.949 24.505 52.729 1.00 47.25 C ATOM 218 N PRO A 32 5.213 24.590 52.840 1.00 44.06 N ATOM 219 CA PRO A 32 4.080 25.511 52.751 1.00 45.57 C ATOM 220 C PRO A 32 4.173 26.667 53.739 1.00 45.58 C ATOM 221 O PRO A 32 4.629 26.491 54.871 1.00 45.24 O ATOM 222 CB PRO A 32 2.873 24.603 53.009 1.00 45.74 C ATOM 223 CG PRO A 32 3.440 23.517 53.878 1.00 45.95 C ATOM 224 CD PRO A 32 4.770 23.239 53.227 1.00 44.88 C ATOM 225 N GLY A 33 3.770 27.854 53.284 1.00 45.42 N ATOM 226 CA GLY A 33 3.774 29.029 54.135 1.00 45.46 C ATOM 227 C GLY A 33 5.040 29.840 54.368 1.00 46.44 C ATOM 228 O GLY A 33 5.157 30.484 55.407 1.00 48.63 O ATOM 229 N VAL A 34 5.988 29.846 53.442 1.00 47.14 N ATOM 230 CA VAL A 34 7.197 30.640 53.673 1.00 47.91 C ATOM 231 C VAL A 34 6.934 32.126 53.383 1.00 46.22 C ATOM 232 O VAL A 34 6.032 32.463 52.621 1.00 43.32 O ATOM 233 CB VAL A 34 8.397 30.125 52.815 1.00 48.47 C ATOM 234 CG1 VAL A 34 8.550 28.624 53.006 1.00 48.22 C ATOM 235 CG2 VAL A 34 8.209 30.475 51.351 1.00 47.13 C ATOM 236 N ASP A 35 7.722 33.005 53.998 1.00 47.88 N ATOM 237 CA ASP A 35 7.549 34.445 53.816 1.00 50.42 C ATOM 238 C ASP A 35 8.126 35.028 52.532 1.00 51.68 C ATOM 239 O ASP A 35 7.454 35.791 51.837 1.00 53.57 O ATOM 240 CB ASP A 35 8.159 35.216 54.986 1.00 52.59 C ATOM 241 CG ASP A 35 7.563 34.828 56.323 1.00 56.56 C ATOM 242 OD1 ASP A 35 6.344 34.545 56.382 1.00 57.95 O ATOM 243 OD2 ASP A 35 8.318 34.826 57.320 1.00 56.86 O ATOM 244 N LEU A 36 9.376 34.690 52.228 1.00 50.43 N ATOM 245 CA LEU A 36 10.036 35.217 51.039 1.00 47.88 C ATOM 246 C LEU A 36 10.804 34.160 50.272 1.00 45.79 C ATOM 247 O LEU A 36 11.325 33.200 50.844 1.00 45.41 O ATOM 248 CB LEU A 36 11.015 36.327 51.426 1.00 49.31 C ATOM 249 CG LEU A 36 11.900 36.856 50.293 1.00 51.03 C ATOM 250 CD1 LEU A 36 11.122 37.898 49.522 1.00 53.68 C ATOM 251 CD2 LEU A 36 13.183 37.463 50.842 1.00 51.00 C ATOM 252 N TYR A 37 10.877 34.357 48.964 1.00 43.09 N ATOM 253 CA TYR A 37 11.608 33.456 48.083 1.00 40.09 C ATOM 254 C TYR A 37 12.697 34.279 47.423 1.00 37.71 C ATOM 255 O TYR A 37 12.498 35.462 47.144 1.00 34.88 O ATOM 256 CB TYR A 37 10.681 32.889 47.003 1.00 39.80 C ATOM 257 CG TYR A 37 10.011 31.593 47.375 1.00 40.48 C ATOM 258 CD1 TYR A 37 10.750 30.423 47.494 1.00 40.94 C ATOM 259 CD2 TYR A 37 8.640 31.529 47.593 1.00 39.67 C ATOM 260 CE1 TYR A 37 10.145 29.216 47.816 1.00 42.03 C ATOM 261 CE2 TYR A 37 8.022 30.326 47.919 1.00 41.98 C ATOM 262 CZ TYR A 37 8.782 29.172 48.030 1.00 43.11 C ATOM 263 OH TYR A 37 8.194 27.971 48.370 1.00 44.98 O ATOM 264 N ARG A 38 13.853 33.666 47.194 1.00 35.91 N ATOM 265 CA ARG A 38 14.941 34.363 46.522 1.00 34.57 C ATOM 266 C ARG A 38 15.574 33.461 45.463 1.00 35.68 C ATOM 267 O ARG A 38 16.147 32.413 45.767 1.00 34.07 O ATOM 268 CB ARG A 38 15.984 34.832 47.528 1.00 34.34 C ATOM 269 CG ARG A 38 17.031 35.732 46.909 1.00 34.46 C ATOM 270 CD ARG A 38 17.759 36.532 47.978 1.00 37.79 C ATOM 271 NE ARG A 38 16.949 37.641 48.479 1.00 36.62 N ATOM 272 CZ ARG A 38 17.299 38.428 49.492 1.00 35.61 C ATOM 273 NH1 ARG A 38 18.447 38.236 50.129 1.00 35.44 N ATOM 274 NH2 ARG A 38 16.501 39.416 49.862 1.00 37.22 N ATOM 275 N LEU A 39 15.448 33.883 44.208 1.00 36.80 N ATOM 276 CA LEU A 39 15.960 33.133 43.069 1.00 36.94 C ATOM 277 C LEU A 39 17.096 33.903 42.408 1.00 37.01 C ATOM 278 O LEU A 39 16.911 35.028 41.951 1.00 37.30 O ATOM 279 CB LEU A 39 14.813 32.889 42.071 1.00 34.67 C ATOM 280 CG LEU A 39 15.011 32.050 40.804 1.00 35.32 C ATOM 281 CD1 LEU A 39 15.738 32.860 39.755 1.00 37.79 C ATOM 282 CD2 LEU A 39 15.774 30.772 41.130 1.00 33.19 C ATOM 283 N GLU A 40 18.270 33.287 42.345 1.00 37.09 N ATOM 284 CA GLU A 40 19.421 33.945 41.752 1.00 38.13 C ATOM 285 C GLU A 40 20.091 33.170 40.627 1.00 39.04 C ATOM 286 O GLU A 40 19.930 31.957 40.494 1.00 38.42 O ATOM 287 CB GLU A 40 20.477 34.217 42.826 1.00 36.49 C ATOM 288 CG GLU A 40 20.930 32.955 43.538 1.00 37.50 C ATOM 289 CD GLU A 40 22.310 33.076 44.168 1.00 37.73 C ATOM 290 OE1 GLU A 40 22.641 34.156 44.688 1.00 38.96 O ATOM 291 OE2 GLU A 40 23.057 32.078 44.158 1.00 37.88 O ATOM 292 N LYS A 41 20.851 33.905 39.822 1.00 40.49 N ATOM 293 CA LYS A 41 21.629 33.334 38.739 1.00 41.35 C ATOM 294 C LYS A 41 23.048 33.579 39.224 1.00 41.89 C ATOM 295 O LYS A 41 23.397 34.711 39.545 1.00 43.48 O ATOM 296 CB LYS A 41 21.376 34.082 37.426 1.00 41.18 C ATOM 297 CG LYS A 41 22.056 33.427 36.232 1.00 41.99 C ATOM 298 CD LYS A 41 21.451 33.847 34.904 1.00 42.93 C ATOM 299 CE LYS A 41 22.060 33.042 33.751 1.00 42.44 C ATOM 300 NZ LYS A 41 23.532 33.264 33.631 1.00 39.72 N ATOM 301 N LEU A 42 23.862 32.534 39.300 1.00 42.73 N ATOM 302 CA LEU A 42 25.230 32.685 39.792 1.00 44.77 C ATOM 303 C LEU A 42 26.161 33.582 38.970 1.00 47.34 C ATOM 304 O LEU A 42 27.075 34.192 39.522 1.00 48.33 O ATOM 305 CB LEU A 42 25.875 31.310 39.961 1.00 44.18 C ATOM 306 CG LEU A 42 25.597 30.528 41.250 1.00 46.39 C ATOM 307 CD1 LEU A 42 24.102 30.436 41.531 1.00 47.52 C ATOM 308 CD2 LEU A 42 26.197 29.139 41.116 1.00 45.89 C ATOM 309 N SER A 43 25.928 33.678 37.662 1.00 50.78 N ATOM 310 CA SER A 43 26.784 34.485 36.781 1.00 52.46 C ATOM 311 C SER A 43 26.719 35.984 37.034 1.00 53.08 C ATOM 312 O SER A 43 27.706 36.692 36.858 1.00 53.09 O ATOM 313 CB SER A 43 26.429 34.235 35.318 1.00 54.08 C ATOM 314 OG SER A 43 25.235 34.918 34.969 1.00 57.23 O ATOM 315 N SER A 44 25.549 36.470 37.424 1.00 53.69 N ATOM 316 CA SER A 44 25.384 37.890 37.691 1.00 54.44 C ATOM 317 C SER A 44 25.152 38.117 39.174 1.00 54.36 C ATOM 318 O SER A 44 25.174 39.256 39.642 1.00 55.26 O ATOM 319 CB SER A 44 24.194 38.452 36.907 1.00 54.40 C ATOM 320 OG SER A 44 22.965 37.996 37.446 1.00 52.76 O ATOM 321 N SER A 45 24.931 37.028 39.906 1.00 54.21 N ATOM 322 CA SER A 45 24.670 37.100 41.339 1.00 55.36 C ATOM 323 C SER A 45 23.398 37.942 41.581 1.00 56.77 C ATOM 324 O SER A 45 23.005 38.211 42.726 1.00 57.29 O ATOM 325 CB SER A 45 25.874 37.714 42.059 1.00 54.86 C ATOM 326 OG SER A 45 25.744 37.588 43.465 1.00 55.22 O ATOM 327 N ARG A 46 22.760 38.338 40.481 1.00 55.68 N ATOM 328 CA ARG A 46 21.537 39.139 40.498 1.00 54.87 C ATOM 329 C ARG A 46 20.390 38.198 40.850 1.00 53.65 C ATOM 330 O ARG A 46 20.383 37.037 40.422 1.00 54.29 O ATOM 331 CB ARG A 46 21.323 39.748 39.115 1.00 55.68 C ATOM 332 CG ARG A 46 20.245 40.788 39.003 1.00 58.65 C ATOM 333 CD ARG A 46 20.437 41.566 37.700 1.00 61.22 C ATOM 334 NE ARG A 46 19.379 42.543 37.445 1.00 64.20 N ATOM 335 CZ ARG A 46 18.099 42.231 37.259 1.00 65.46 C ATOM 336 NH1 ARG A 46 17.705 40.962 37.302 1.00 66.82 N ATOM 337 NH2 ARG A 46 17.212 43.187 37.018 1.00 65.80 N ATOM 338 N TYR A 47 19.424 38.693 41.621 1.00 48.93 N ATOM 339 CA TYR A 47 18.307 37.860 42.043 1.00 44.13 C ATOM 340 C TYR A 47 16.954 38.548 41.921 1.00 42.46 C ATOM 341 O TYR A 47 16.856 39.697 41.505 1.00 41.50 O ATOM 342 CB TYR A 47 18.521 37.419 43.498 1.00 42.44 C ATOM 343 CG TYR A 47 18.368 38.530 44.522 1.00 40.22 C ATOM 344 CD1 TYR A 47 17.100 38.955 44.938 1.00 40.83 C ATOM 345 CD2 TYR A 47 19.483 39.166 45.060 1.00 40.63 C ATOM 346 CE1 TYR A 47 16.942 39.981 45.861 1.00 39.17 C ATOM 347 CE2 TYR A 47 19.343 40.205 45.993 1.00 41.62 C ATOM 348 CZ TYR A 47 18.064 40.607 46.389 1.00 42.71 C ATOM 349 OH TYR A 47 17.905 41.624 47.313 1.00 40.68 O ATOM 350 N GLN A 48 15.913 37.812 42.287 1.00 40.15 N ATOM 351 CA GLN A 48 14.551 38.311 42.265 1.00 40.50 C ATOM 352 C GLN A 48 13.897 37.659 43.481 1.00 42.10 C ATOM 353 O GLN A 48 14.161 36.487 43.767 1.00 43.31 O ATOM 354 CB GLN A 48 13.834 37.885 40.979 1.00 36.35 C ATOM 355 CG GLN A 48 13.610 36.390 40.843 1.00 35.27 C ATOM 356 CD GLN A 48 12.717 36.020 39.658 1.00 34.35 C ATOM 357 OE1 GLN A 48 12.964 36.437 38.524 1.00 30.96 O ATOM 358 NE2 GLN A 48 11.678 35.224 39.921 1.00 30.08 N ATOM 359 N ASP A 49 13.064 38.407 44.203 1.00 42.67 N ATOM 360 CA ASP A 49 12.416 37.863 45.387 1.00 42.99 C ATOM 361 C ASP A 49 11.067 37.201 45.143 1.00 42.96 C ATOM 362 O ASP A 49 10.090 37.495 45.826 1.00 43.87 O ATOM 363 CB ASP A 49 12.274 38.941 46.463 1.00 46.87 C ATOM 364 CG ASP A 49 13.508 39.044 47.356 1.00 53.22 C ATOM 365 OD1 ASP A 49 14.113 37.990 47.653 1.00 56.74 O ATOM 366 OD2 ASP A 49 13.865 40.170 47.782 1.00 56.49 O ATOM 367 N GLN A 50 11.026 36.297 44.168 1.00 43.17 N ATOM 368 CA GLN A 50 9.815 35.546 43.827 1.00 42.42 C ATOM 369 C GLN A 50 10.270 34.150 43.409 1.00 40.92 C ATOM 370 O GLN A 50 11.393 33.974 42.938 1.00 41.96 O ATOM 371 CB GLN A 50 9.065 36.220 42.678 1.00 43.36 C ATOM 372 CG GLN A 50 8.727 37.671 42.953 1.00 47.38 C ATOM 373 CD GLN A 50 8.339 38.436 41.701 1.00 49.06 C ATOM 374 OE1 GLN A 50 7.226 38.295 41.191 1.00 49.34 O ATOM 375 NE2 GLN A 50 9.268 39.248 41.193 1.00 49.25 N ATOM 376 N ALA A 51 9.394 33.167 43.567 1.00 38.06 N ATOM 377 CA ALA A 51 9.725 31.791 43.238 1.00 36.47 C ATOM 378 C ALA A 51 9.690 31.415 41.758 1.00 36.25 C ATOM 379 O ALA A 51 10.347 30.463 41.345 1.00 36.75 O ATOM 380 CB ALA A 51 8.814 30.853 44.023 1.00 34.79 C ATOM 381 N VAL A 52 8.940 32.142 40.944 1.00 34.58 N ATOM 382 CA VAL A 52 8.869 31.765 39.544 1.00 35.03 C ATOM 383 C VAL A 52 9.476 32.745 38.559 1.00 36.34 C ATOM 384 O VAL A 52 9.241 33.947 38.638 1.00 36.38 O ATOM 385 CB VAL A 52 7.411 31.494 39.109 1.00 34.36 C ATOM 386 CG1 VAL A 52 7.379 31.044 37.649 1.00 34.41 C ATOM 387 CG2 VAL A 52 6.789 30.441 40.004 1.00 32.40 C ATOM 388 N LEU A 53 10.271 32.205 37.638 1.00 36.79 N ATOM 389 CA LEU A 53 10.902 32.988 36.581 1.00 38.89 C ATOM 390 C LEU A 53 10.425 32.386 35.264 1.00 40.26 C ATOM 391 O LEU A 53 10.562 31.192 35.034 1.00 40.57 O ATOM 392 CB LEU A 53 12.432 32.911 36.654 1.00 37.28 C ATOM 393 CG LEU A 53 13.179 33.484 35.434 1.00 36.25 C ATOM 394 CD1 LEU A 53 12.703 34.895 35.168 1.00 34.47 C ATOM 395 CD2 LEU A 53 14.691 33.466 35.660 1.00 33.31 C ATOM 396 N PHE A 54 9.834 33.208 34.411 1.00 44.05 N ATOM 397 CA PHE A 54 9.358 32.722 33.126 1.00 45.97 C ATOM 398 C PHE A 54 10.245 33.266 32.028 1.00 46.61 C ATOM 399 O PHE A 54 10.545 34.460 31.986 1.00 46.74 O ATOM 400 CB PHE A 54 7.921 33.170 32.863 1.00 47.72 C ATOM 401 CG PHE A 54 7.419 32.798 31.498 1.00 49.53 C ATOM 402 CD1 PHE A 54 7.126 31.474 31.188 1.00 50.51 C ATOM 403 CD2 PHE A 54 7.265 33.770 30.510 1.00 52.23 C ATOM 404 CE1 PHE A 54 6.686 31.119 29.911 1.00 51.59 C ATOM 405 CE2 PHE A 54 6.825 33.429 29.224 1.00 52.07 C ATOM 406 CZ PHE A 54 6.536 32.100 28.926 1.00 52.46 C ATOM 407 N ILE A 55 10.684 32.379 31.150 1.00 47.45 N ATOM 408 CA ILE A 55 11.511 32.783 30.033 1.00 48.36 C ATOM 409 C ILE A 55 10.720 32.436 28.774 1.00 50.14 C ATOM 410 O ILE A 55 10.659 31.275 28.364 1.00 51.51 O ATOM 411 CB ILE A 55 12.866 32.050 30.049 1.00 47.42 C ATOM 412 CG1 ILE A 55 13.654 32.465 31.301 1.00 48.91 C ATOM 413 CG2 ILE A 55 13.646 32.363 28.786 1.00 46.22 C ATOM 414 CD1 ILE A 55 15.057 31.856 31.417 1.00 46.40 C ATOM 415 N PRO A 56 10.074 33.446 28.161 1.00 50.85 N ATOM 416 CA PRO A 56 9.284 33.227 26.946 1.00 50.59 C ATOM 417 C PRO A 56 10.118 32.634 25.812 1.00 50.00 C ATOM 418 O PRO A 56 9.685 31.711 25.129 1.00 51.30 O ATOM 419 CB PRO A 56 8.748 34.627 26.629 1.00 49.33 C ATOM 420 CG PRO A 56 9.793 35.532 27.193 1.00 49.27 C ATOM 421 CD PRO A 56 10.112 34.880 28.508 1.00 49.80 C ATOM 422 N ALA A 57 11.319 33.168 25.627 1.00 49.28 N ATOM 423 CA ALA A 57 12.218 32.693 24.587 1.00 47.75 C ATOM 424 C ALA A 57 13.628 32.555 25.159 1.00 47.57 C ATOM 425 O ALA A 57 14.267 33.541 25.533 1.00 47.50 O ATOM 426 CB ALA A 57 12.211 33.659 23.406 1.00 47.04 C ATOM 427 N MET A 58 14.100 31.316 25.219 1.00 46.93 N ATOM 428 CA MET A 58 15.415 30.994 25.749 1.00 47.22 C ATOM 429 C MET A 58 16.552 31.707 25.007 1.00 47.84 C ATOM 430 O MET A 58 16.658 31.626 23.784 1.00 48.95 O ATOM 431 CB MET A 58 15.608 29.475 25.692 1.00 46.57 C ATOM 432 CG MET A 58 16.918 28.971 26.255 1.00 46.65 C ATOM 433 SD MET A 58 17.113 29.353 27.990 1.00 47.35 S ATOM 434 CE MET A 58 18.894 29.486 28.106 1.00 46.29 C ATOM 435 N LYS A 59 17.397 32.411 25.753 1.00 47.43 N ATOM 436 CA LYS A 59 18.529 33.119 25.163 1.00 48.57 C ATOM 437 C LYS A 59 19.846 32.562 25.682 1.00 48.47 C ATOM 438 O LYS A 59 19.913 32.006 26.779 1.00 48.00 O ATOM 439 CB LYS A 59 18.453 34.623 25.459 1.00 50.26 C ATOM 440 CG LYS A 59 17.358 35.337 24.687 1.00 52.84 C ATOM 441 CD LYS A 59 17.272 36.805 25.043 1.00 56.18 C ATOM 442 CE LYS A 59 16.178 37.494 24.229 1.00 58.39 C ATOM 443 NZ LYS A 59 15.939 38.902 24.663 1.00 60.23 N ATOM 444 N ARG A 60 20.889 32.717 24.878 1.00 48.60 N ATOM 445 CA ARG A 60 22.216 32.232 25.218 1.00 49.42 C ATOM 446 C ARG A 60 22.651 32.754 26.584 1.00 49.30 C ATOM 447 O ARG A 60 23.099 31.987 27.439 1.00 50.29 O ATOM 448 CB ARG A 60 23.202 32.676 24.137 1.00 52.04 C ATOM 449 CG ARG A 60 22.706 32.380 22.720 1.00 57.97 C ATOM 450 CD ARG A 60 23.377 33.244 21.651 1.00 60.53 C ATOM 451 NE ARG A 60 24.440 32.540 20.939 1.00 64.59 N ATOM 452 CZ ARG A 60 25.611 32.203 21.471 1.00 66.72 C ATOM 453 NH1 ARG A 60 25.884 32.507 22.737 1.00 67.54 N ATOM 454 NH2 ARG A 60 26.515 31.565 20.733 1.00 66.76 N ATOM 455 N SER A 61 22.500 34.059 26.788 1.00 48.75 N ATOM 456 CA SER A 61 22.889 34.700 28.042 1.00 47.51 C ATOM 457 C SER A 61 22.035 34.264 29.225 1.00 46.65 C ATOM 458 O SER A 61 22.355 34.576 30.372 1.00 46.25 O ATOM 459 CB SER A 61 22.801 36.212 27.901 1.00 46.42 C ATOM 460 OG SER A 61 21.474 36.588 27.580 1.00 48.36 O ATOM 461 N LEU A 62 20.945 33.554 28.948 1.00 44.98 N ATOM 462 CA LEU A 62 20.063 33.088 30.009 1.00 42.71 C ATOM 463 C LEU A 62 20.442 31.687 30.467 1.00 42.89 C ATOM 464 O LEU A 62 19.861 31.159 31.417 1.00 43.62 O ATOM 465 CB LEU A 62 18.604 33.094 29.542 1.00 42.46 C ATOM 466 CG LEU A 62 17.898 34.441 29.333 1.00 42.16 C ATOM 467 CD1 LEU A 62 16.433 34.190 28.989 1.00 40.12 C ATOM 468 CD2 LEU A 62 18.002 35.294 30.593 1.00 39.63 C ATOM 469 N ALA A 63 21.405 31.076 29.783 1.00 41.51 N ATOM 470 CA ALA A 63 21.849 29.740 30.159 1.00 40.31 C ATOM 471 C ALA A 63 22.768 29.920 31.349 1.00 38.78 C ATOM 472 O ALA A 63 23.254 31.023 31.591 1.00 37.40 O ATOM 473 CB ALA A 63 22.598 29.087 29.019 1.00 41.16 C ATOM 474 N GLY A 64 23.000 28.844 32.093 1.00 38.07 N ATOM 475 CA GLY A 64 23.869 28.925 33.255 1.00 34.77 C ATOM 476 C GLY A 64 23.247 28.348 34.516 1.00 35.87 C ATOM 477 O GLY A 64 22.182 27.719 34.478 1.00 34.05 O ATOM 478 N ARG A 65 23.916 28.575 35.644 1.00 35.75 N ATOM 479 CA ARG A 65 23.456 28.072 36.930 1.00 36.32 C ATOM 480 C ARG A 65 22.507 29.002 37.695 1.00 35.62 C ATOM 481 O ARG A 65 22.688 30.214 37.722 1.00 36.12 O ATOM 482 CB ARG A 65 24.663 27.749 37.805 1.00 36.14 C ATOM 483 CG ARG A 65 25.539 26.654 37.245 1.00 39.20 C ATOM 484 CD ARG A 65 26.743 26.435 38.135 1.00 40.84 C ATOM 485 NE ARG A 65 27.683 27.548 38.049 1.00 46.60 N ATOM 486 CZ ARG A 65 28.566 27.852 38.998 1.00 49.97 C ATOM 487 NH1 ARG A 65 28.621 27.123 40.110 1.00 51.95 N ATOM 488 NH2 ARG A 65 29.395 28.878 38.838 1.00 48.38 N ATOM 489 N TYR A 66 21.488 28.412 38.312 1.00 36.03 N ATOM 490 CA TYR A 66 20.520 29.154 39.112 1.00 35.66 C ATOM 491 C TYR A 66 20.399 28.471 40.474 1.00 35.44 C ATOM 492 O TYR A 66 20.623 27.262 40.600 1.00 32.48 O ATOM 493 CB TYR A 66 19.139 29.195 38.439 1.00 33.94 C ATOM 494 CG TYR A 66 19.073 30.040 37.187 1.00 35.26 C ATOM 495 CD1 TYR A 66 19.664 29.607 35.997 1.00 35.29 C ATOM 496 CD2 TYR A 66 18.403 31.269 37.186 1.00 35.38 C ATOM 497 CE1 TYR A 66 19.586 30.376 34.835 1.00 38.15 C ATOM 498 CE2 TYR A 66 18.318 32.049 36.031 1.00 35.82 C ATOM 499 CZ TYR A 66 18.913 31.597 34.861 1.00 37.67 C ATOM 500 OH TYR A 66 18.865 32.361 33.721 1.00 36.06 O ATOM 501 N ARG A 67 20.023 29.250 41.484 1.00 33.50 N ATOM 502 CA ARG A 67 19.898 28.736 42.829 1.00 33.44 C ATOM 503 C ARG A 67 18.835 29.543 43.560 1.00 34.55 C ATOM 504 O ARG A 67 18.542 30.677 43.194 1.00 33.17 O ATOM 505 CB ARG A 67 21.261 28.863 43.513 1.00 35.35 C ATOM 506 CG ARG A 67 21.391 28.297 44.917 1.00 35.74 C ATOM 507 CD ARG A 67 22.847 28.419 45.384 1.00 34.82 C ATOM 508 NE ARG A 67 23.412 29.753 45.142 1.00 34.51 N ATOM 509 CZ ARG A 67 24.720 30.023 45.130 1.00 36.05 C ATOM 510 NH1 ARG A 67 25.606 29.056 45.354 1.00 35.08 N ATOM 511 NH2 ARG A 67 25.151 31.247 44.863 1.00 33.21 N ATOM 512 N CYS A 68 18.237 28.963 44.591 1.00 36.11 N ATOM 513 CA CYS A 68 17.231 29.708 45.324 1.00 36.23 C ATOM 514 C CYS A 68 17.143 29.295 46.779 1.00 34.77 C ATOM 515 O CYS A 68 17.493 28.167 47.151 1.00 32.91 O ATOM 516 CB CYS A 68 15.852 29.574 44.646 1.00 38.97 C ATOM 517 SG CYS A 68 14.977 27.974 44.819 1.00 43.57 S ATOM 518 N SER A 69 16.697 30.244 47.597 1.00 34.26 N ATOM 519 CA SER A 69 16.496 30.041 49.027 1.00 32.89 C ATOM 520 C SER A 69 15.223 30.764 49.427 1.00 31.99 C ATOM 521 O SER A 69 14.726 31.621 48.698 1.00 31.96 O ATOM 522 CB SER A 69 17.665 30.614 49.834 1.00 32.13 C ATOM 523 OG SER A 69 18.824 29.818 49.706 1.00 33.70 O ATOM 524 N TYR A 70 14.680 30.413 50.582 1.00 32.97 N ATOM 525 CA TYR A 70 13.488 31.090 51.062 1.00 32.08 C ATOM 526 C TYR A 70 13.722 31.525 52.496 1.00 34.30 C ATOM 527 O TYR A 70 14.528 30.923 53.223 1.00 32.97 O ATOM 528 CB TYR A 70 12.254 30.181 50.976 1.00 30.90 C ATOM 529 CG TYR A 70 12.342 28.912 51.792 1.00 28.11 C ATOM 530 CD1 TYR A 70 12.878 27.741 51.255 1.00 27.08 C ATOM 531 CD2 TYR A 70 11.900 28.890 53.106 1.00 27.48 C ATOM 532 CE1 TYR A 70 12.964 26.572 52.018 1.00 26.37 C ATOM 533 CE2 TYR A 70 11.983 27.740 53.873 1.00 28.63 C ATOM 534 CZ TYR A 70 12.513 26.586 53.330 1.00 26.47 C ATOM 535 OH TYR A 70 12.588 25.463 54.125 1.00 28.38 O ATOM 536 N GLN A 71 13.027 32.584 52.896 1.00 36.17 N ATOM 537 CA GLN A 71 13.146 33.101 54.250 1.00 39.39 C ATOM 538 C GLN A 71 11.792 33.030 54.960 1.00 42.07 C ATOM 539 O GLN A 71 10.820 33.647 54.519 1.00 43.73 O ATOM 540 CB GLN A 71 13.632 34.553 54.215 1.00 38.37 C ATOM 541 CG GLN A 71 14.301 35.009 55.505 1.00 40.71 C ATOM 542 CD GLN A 71 14.639 36.489 55.519 1.00 39.69 C ATOM 543 OE1 GLN A 71 15.440 36.939 56.331 1.00 41.69 O ATOM 544 NE2 GLN A 71 14.023 37.251 54.628 1.00 43.75 N ATOM 545 N ASN A 72 11.713 32.260 56.040 1.00 44.13 N ATOM 546 CA ASN A 72 10.469 32.169 56.796 1.00 47.20 C ATOM 547 C ASN A 72 10.764 32.776 58.153 1.00 49.17 C ATOM 548 O ASN A 72 11.674 32.333 58.858 1.00 50.48 O ATOM 549 CB ASN A 72 10.018 30.730 56.976 1.00 49.67 C ATOM 550 CG ASN A 72 8.616 30.643 57.531 1.00 53.91 C ATOM 551 OD1 ASN A 72 8.308 29.781 58.362 1.00 55.73 O ATOM 552 ND2 ASN A 72 7.749 31.540 57.070 1.00 53.55 N ATOM 553 N GLY A 73 9.990 33.781 58.535 1.00 49.93 N ATOM 554 CA GLY A 73 10.273 34.444 59.790 1.00 51.94 C ATOM 555 C GLY A 73 11.516 35.238 59.439 1.00 52.46 C ATOM 556 O GLY A 73 11.486 36.038 58.501 1.00 54.47 O ATOM 557 N SER A 74 12.612 35.019 60.154 1.00 51.39 N ATOM 558 CA SER A 74 13.843 35.730 59.832 1.00 50.19 C ATOM 559 C SER A 74 14.915 34.697 59.528 1.00 49.05 C ATOM 560 O SER A 74 16.081 35.036 59.331 1.00 49.81 O ATOM 561 CB SER A 74 14.302 36.600 61.002 1.00 50.65 C ATOM 562 OG SER A 74 14.955 35.816 61.987 1.00 52.99 O ATOM 563 N LEU A 75 14.509 33.432 59.488 1.00 46.78 N ATOM 564 CA LEU A 75 15.440 32.345 59.227 1.00 44.10 C ATOM 565 C LEU A 75 15.540 31.968 57.751 1.00 41.29 C ATOM 566 O LEU A 75 14.532 31.866 57.055 1.00 41.53 O ATOM 567 CB LEU A 75 15.033 31.101 60.025 1.00 44.88 C ATOM 568 CG LEU A 75 14.920 31.150 61.551 1.00 45.09 C ATOM 569 CD1 LEU A 75 14.461 29.789 62.028 1.00 44.50 C ATOM 570 CD2 LEU A 75 16.254 31.507 62.198 1.00 44.43 C ATOM 571 N TRP A 76 16.768 31.762 57.283 1.00 37.58 N ATOM 572 CA TRP A 76 17.010 31.355 55.906 1.00 34.46 C ATOM 573 C TRP A 76 17.068 29.840 55.835 1.00 34.34 C ATOM 574 O TRP A 76 17.255 29.160 56.848 1.00 33.43 O ATOM 575 CB TRP A 76 18.331 31.922 55.382 1.00 32.31 C ATOM 576 CG TRP A 76 18.210 33.329 54.926 1.00 33.41 C ATOM 577 CD1 TRP A 76 18.568 34.456 55.612 1.00 31.26 C ATOM 578 CD2 TRP A 76 17.640 33.772 53.693 1.00 32.98 C ATOM 579 NE1 TRP A 76 18.251 35.575 54.880 1.00 30.99 N ATOM 580 CE2 TRP A 76 17.680 35.184 53.697 1.00 33.15 C ATOM 581 CE3 TRP A 76 17.095 33.112 52.582 1.00 32.76 C ATOM 582 CZ2 TRP A 76 17.198 35.950 52.629 1.00 33.35 C ATOM 583 CZ3 TRP A 76 16.615 33.873 51.521 1.00 32.91 C ATOM 584 CH2 TRP A 76 16.672 35.280 51.554 1.00 32.34 C ATOM 585 N SER A 77 16.912 29.318 54.626 1.00 33.46 N ATOM 586 CA SER A 77 16.952 27.882 54.393 1.00 32.01 C ATOM 587 C SER A 77 18.271 27.582 53.730 1.00 31.41 C ATOM 588 O SER A 77 18.934 28.487 53.229 1.00 29.92 O ATOM 589 CB SER A 77 15.835 27.468 53.438 1.00 30.61 C ATOM 590 OG SER A 77 16.023 28.071 52.155 1.00 30.27 O ATOM 591 N LEU A 78 18.660 26.315 53.733 1.00 32.01 N ATOM 592 CA LEU A 78 19.884 25.939 53.052 1.00 31.48 C ATOM 593 C LEU A 78 19.532 26.302 51.608 1.00 31.37 C ATOM 594 O LEU A 78 18.345 26.407 51.269 1.00 29.32 O ATOM 595 CB LEU A 78 20.134 24.440 53.193 1.00 29.42 C ATOM 596 CG LEU A 78 20.251 23.936 54.639 1.00 30.75 C ATOM 597 CD1 LEU A 78 20.426 22.426 54.650 1.00 28.45 C ATOM 598 CD2 LEU A 78 21.435 24.606 55.332 1.00 28.78 C ATOM 599 N PRO A 79 20.544 26.535 50.752 1.00 30.45 N ATOM 600 CA PRO A 79 20.272 26.887 49.357 1.00 29.21 C ATOM 601 C PRO A 79 19.825 25.654 48.585 1.00 30.07 C ATOM 602 O PRO A 79 20.242 24.542 48.915 1.00 28.80 O ATOM 603 CB PRO A 79 21.613 27.420 48.881 1.00 27.28 C ATOM 604 CG PRO A 79 22.579 26.562 49.633 1.00 26.60 C ATOM 605 CD PRO A 79 21.995 26.523 51.018 1.00 28.42 C ATOM 606 N SER A 80 18.973 25.836 47.577 1.00 29.26 N ATOM 607 CA SER A 80 18.517 24.690 46.791 1.00 30.42 C ATOM 608 C SER A 80 19.706 24.196 46.007 1.00 30.66 C ATOM 609 O SER A 80 20.740 24.865 45.949 1.00 31.82 O ATOM 610 CB SER A 80 17.426 25.082 45.788 1.00 30.12 C ATOM 611 OG SER A 80 17.982 25.792 44.688 1.00 31.17 O ATOM 612 N ASP A 81 19.566 23.016 45.418 1.00 32.95 N ATOM 613 CA ASP A 81 20.626 22.475 44.587 1.00 33.94 C ATOM 614 C ASP A 81 20.673 23.405 43.389 1.00 34.67 C ATOM 615 O ASP A 81 19.671 24.036 43.045 1.00 35.97 O ATOM 616 CB ASP A 81 20.291 21.061 44.109 1.00 32.96 C ATOM 617 CG ASP A 81 20.410 20.031 45.208 1.00 34.99 C ATOM 618 OD1 ASP A 81 21.137 20.298 46.190 1.00 32.41 O ATOM 619 OD2 ASP A 81 19.789 18.950 45.079 1.00 37.82 O ATOM 620 N GLN A 82 21.833 23.497 42.757 1.00 36.07 N ATOM 621 CA GLN A 82 21.983 24.357 41.597 1.00 36.17 C ATOM 622 C GLN A 82 21.218 23.787 40.400 1.00 34.51 C ATOM 623 O GLN A 82 21.231 22.583 40.152 1.00 32.73 O ATOM 624 CB GLN A 82 23.475 24.524 41.278 1.00 37.74 C ATOM 625 CG GLN A 82 24.207 25.350 42.338 1.00 45.98 C ATOM 626 CD GLN A 82 25.728 25.267 42.247 1.00 50.85 C ATOM 627 OE1 GLN A 82 26.325 25.562 41.205 1.00 52.48 O ATOM 628 NE2 GLN A 82 26.364 24.872 43.351 1.00 52.90 N ATOM 629 N LEU A 83 20.509 24.657 39.691 1.00 34.25 N ATOM 630 CA LEU A 83 19.765 24.250 38.506 1.00 33.95 C ATOM 631 C LEU A 83 20.645 24.716 37.359 1.00 34.00 C ATOM 632 O LEU A 83 21.021 25.893 37.294 1.00 31.52 O ATOM 633 CB LEU A 83 18.391 24.940 38.454 1.00 34.85 C ATOM 634 CG LEU A 83 17.344 24.594 37.368 1.00 37.20 C ATOM 635 CD1 LEU A 83 17.692 25.232 36.035 1.00 36.69 C ATOM 636 CD2 LEU A 83 17.246 23.096 37.215 1.00 36.48 C ATOM 637 N GLU A 84 21.005 23.783 36.481 1.00 33.45 N ATOM 638 CA GLU A 84 21.847 24.099 35.334 1.00 33.81 C ATOM 639 C GLU A 84 20.975 24.285 34.095 1.00 33.82 C ATOM 640 O GLU A 84 20.643 23.319 33.406 1.00 34.73 O ATOM 641 CB GLU A 84 22.856 22.973 35.107 1.00 35.20 C ATOM 642 CG GLU A 84 23.553 22.520 36.380 1.00 40.56 C ATOM 643 CD GLU A 84 24.639 21.497 36.129 1.00 43.89 C ATOM 644 OE1 GLU A 84 25.743 21.885 35.690 1.00 46.61 O ATOM 645 OE2 GLU A 84 24.386 20.298 36.364 1.00 49.53 O ATOM 646 N LEU A 85 20.587 25.528 33.828 1.00 32.84 N ATOM 647 CA LEU A 85 19.755 25.827 32.672 1.00 32.86 C ATOM 648 C LEU A 85 20.625 25.776 31.415 1.00 33.20 C ATOM 649 O LEU A 85 21.542 26.588 31.240 1.00 32.62 O ATOM 650 CB LEU A 85 19.121 27.208 32.827 1.00 30.55 C ATOM 651 CG LEU A 85 17.902 27.454 31.936 1.00 31.78 C ATOM 652 CD1 LEU A 85 16.818 26.398 32.220 1.00 27.87 C ATOM 653 CD2 LEU A 85 17.367 28.862 32.199 1.00 30.81 C ATOM 654 N VAL A 86 20.330 24.815 30.545 1.00 34.28 N ATOM 655 CA VAL A 86 21.100 24.623 29.318 1.00 34.06 C ATOM 656 C VAL A 86 20.383 25.115 28.070 1.00 35.59 C ATOM 657 O VAL A 86 19.181 24.910 27.911 1.00 36.81 O ATOM 658 CB VAL A 86 21.414 23.121 29.113 1.00 36.33 C ATOM 659 CG1 VAL A 86 22.250 22.913 27.845 1.00 33.73 C ATOM 660 CG2 VAL A 86 22.106 22.557 30.356 1.00 32.81 C ATOM 661 N ALA A 87 21.128 25.769 27.187 1.00 36.51 N ATOM 662 CA ALA A 87 20.582 26.243 25.920 1.00 36.59 C ATOM 663 C ALA A 87 21.090 25.292 24.827 1.00 36.85 C ATOM 664 O ALA A 87 22.299 25.136 24.649 1.00 35.69 O ATOM 665 CB ALA A 87 21.053 27.666 25.636 1.00 36.89 C ATOM 666 N THR A 88 20.164 24.641 24.123 1.00 37.07 N ATOM 667 CA THR A 88 20.524 23.723 23.046 1.00 36.28 C ATOM 668 C THR A 88 20.221 24.408 21.718 1.00 37.73 C ATOM 669 O THR A 88 19.390 25.328 21.640 1.00 36.08 O ATOM 670 CB THR A 88 19.716 22.408 23.094 1.00 37.11 C ATOM 671 OG1 THR A 88 18.355 22.670 22.734 1.00 40.73 O ATOM 672 CG2 THR A 88 19.750 21.801 24.484 1.00 34.19 C ATOM 673 N GLY A 89 20.898 23.953 20.673 1.00 37.63 N ATOM 674 CA GLY A 89 20.703 24.532 19.363 1.00 36.54 C ATOM 675 C GLY A 89 21.611 25.727 19.195 1.00 36.33 C ATOM 676 O GLY A 89 21.334 26.608 18.387 1.00 37.37 O ATOM 677 N VAL A 90 22.692 25.767 19.964 1.00 34.75 N ATOM 678 CA VAL A 90 23.627 26.877 19.878 1.00 36.82 C ATOM 679 C VAL A 90 24.683 26.613 18.814 1.00 38.27 C ATOM 680 O VAL A 90 25.295 27.541 18.285 1.00 37.79 O ATOM 681 CB VAL A 90 24.316 27.124 21.231 1.00 36.86 C ATOM 682 CG1 VAL A 90 25.440 28.131 21.079 1.00 36.51 C ATOM 683 CG2 VAL A 90 23.297 27.625 22.231 1.00 36.33 C ATOM 684 N PHE A 91 24.878 25.337 18.496 1.00 39.84 N ATOM 685 CA PHE A 91 25.855 24.929 17.495 1.00 39.69 C ATOM 686 C PHE A 91 25.239 23.905 16.563 1.00 39.97 C ATOM 687 O PHE A 91 24.156 23.374 16.833 1.00 40.06 O ATOM 688 CB PHE A 91 27.064 24.306 18.181 1.00 41.06 C ATOM 689 CG PHE A 91 27.650 25.165 19.248 1.00 45.64 C ATOM 690 CD1 PHE A 91 28.353 26.318 18.920 1.00 47.20 C ATOM 691 CD2 PHE A 91 27.495 24.831 20.586 1.00 47.80 C ATOM 692 CE1 PHE A 91 28.895 27.128 19.911 1.00 48.30 C ATOM 693 CE2 PHE A 91 28.033 25.635 21.584 1.00 49.88 C ATOM 694 CZ PHE A 91 28.734 26.787 21.246 1.00 49.48 C ATOM 695 N ALA A 92 25.943 23.624 15.471 1.00 39.46 N ATOM 696 CA ALA A 92 25.495 22.638 14.496 1.00 38.27 C ATOM 697 C ALA A 92 25.477 21.278 15.173 1.00 37.48 C ATOM 698 O ALA A 92 26.419 20.912 15.870 1.00 37.07 O ATOM 699 CB ALA A 92 26.436 22.614 13.311 1.00 38.81 C ATOM 700 N LYS A 93 24.396 20.538 14.963 1.00 37.09 N ATOM 701 CA LYS A 93 24.221 19.219 15.556 1.00 37.36 C ATOM 702 C LYS A 93 25.330 18.236 15.177 1.00 37.95 C ATOM 703 O LYS A 93 25.854 18.271 14.064 1.00 40.00 O ATOM 704 CB LYS A 93 22.880 18.632 15.109 1.00 36.45 C ATOM 705 CG LYS A 93 22.804 18.387 13.617 1.00 34.19 C ATOM 706 CD LYS A 93 21.501 17.736 13.232 1.00 35.79 C ATOM 707 CE LYS A 93 21.336 17.687 11.717 1.00 38.64 C ATOM 708 NZ LYS A 93 20.028 17.101 11.306 1.00 40.23 N ATOM 709 N PRO A 94 25.718 17.354 16.109 1.00 36.28 N ATOM 710 CA PRO A 94 26.766 16.396 15.751 1.00 35.49 C ATOM 711 C PRO A 94 26.077 15.225 15.056 1.00 35.71 C ATOM 712 O PRO A 94 24.846 15.222 14.908 1.00 33.82 O ATOM 713 CB PRO A 94 27.353 16.005 17.105 1.00 34.75 C ATOM 714 CG PRO A 94 26.164 16.040 17.995 1.00 32.91 C ATOM 715 CD PRO A 94 25.449 17.321 17.558 1.00 35.55 C ATOM 716 N SER A 95 26.858 14.240 14.626 1.00 34.49 N ATOM 717 CA SER A 95 26.294 13.072 13.979 1.00 33.34 C ATOM 718 C SER A 95 26.581 11.847 14.825 1.00 32.98 C ATOM 719 O SER A 95 27.721 11.584 15.199 1.00 33.16 O ATOM 720 CB SER A 95 26.859 12.914 12.567 1.00 37.77 C ATOM 721 OG SER A 95 28.267 13.047 12.563 1.00 46.35 O ATOM 722 N LEU A 96 25.521 11.105 15.125 1.00 32.83 N ATOM 723 CA LEU A 96 25.586  9.908 15.953 1.00 30.98 C ATOM 724 C LEU A 96 25.614  8.619 15.126 1.00 30.36 C ATOM 725 O LEU A 96 24.748  8.390 14.291 1.00 29.22 O ATOM 726 CB LEU A 96 24.379  9.906 16.902 1.00 30.85 C ATOM 727 CG LEU A 96 24.165  8.777 17.910 1.00 30.98 C ATOM 728 CD1 LEU A 96 25.417  8.597 18.759 1.00 32.84 C ATOM 729 CD2 LEU A 96 22.968  9.115 18.802 1.00 32.70 C ATOM 730 N SER A 97 26.614  7.775 15.361 1.00 30.24 N ATOM 731 CA SER A 97 26.715  6.524 14.627 1.00 30.38 C ATOM 732 C SER A 97 27.099  5.390 15.553 1.00 33.14 C ATOM 733 O SER A 97 27.611  5.621 16.648 1.00 33.20 O ATOM 734 CB SER A 97 27.749  6.636 13.507 1.00 30.12 C ATOM 735 OG SER A 97 29.036  6.936 14.011 1.00 29.03 O ATOM 736 N ALA A 98 26.823  4.165 15.116 1.00 35.13 N ATOM 737 CA ALA A 98 27.161  2.981 15.889 1.00 37.77 C ATOM 738 C ALA A 98 28.562  2.553 15.481 1.00 38.73 C ATOM 739 O ALA A 98 28.945  2.678 14.322 1.00 40.05 O ATOM 740 CB ALA A 98 26.168  1.863 15.604 1.00 37.56 C ATOM 741 N GLN A 99 29.331  2.062 16.439 1.00 41.22 N ATOM 742 CA GLN A 99 30.687  1.617 16.164 1.00 44.62 C ATOM 743 C GLN A 99 30.794  0.106 16.326 1.00 45.05 C ATOM 744 O GLN A 99 30.053 −0.505 17.093 1.00 43.74 O ATOM 745 CB GLN A 99 31.667  2.319 17.104 1.00 45.98 C ATOM 746 CG GLN A 99 31.713  3.832 16.919 1.00 50.14 C ATOM 747 CD GLN A 99 32.265  4.235 15.562 1.00 53.05 C ATOM 748 OE1 GLN A 99 33.348  3.799 15.171 1.00 55.27 O ATOM 749 NE2 GLN A 99 31.525  5.073 14.838 1.00 51.64 N ATOM 750 N PRO A 100 31.727 −0.517 15.599 1.00 46.07 N ATOM 751 CA PRO A 100 31.927 −1.967 15.666 1.00 46.03 C ATOM 752 C PRO A 100 32.283 −2.471 17.056 1.00 44.15 C ATOM 753 O PRO A 100 33.120 −1.888 17.733 1.00 45.12 O ATOM 754 CB PRO A 100 33.050 −2.210 14.654 1.00 47.20 C ATOM 755 CG PRO A 100 33.829 −0.928 14.694 1.00 48.59 C ATOM 756 CD PRO A 100 32.730  0.115 14.724 1.00 47.87 C ATOM 757 N GLY A 101 31.636 −3.552 17.478 1.00 44.40 N ATOM 758 CA GLY A 101 31.924 −4.125 18.783 1.00 46.25 C ATOM 759 C GLY A 101 32.770 −5.378 18.648 1.00 47.05 C ATOM 760 O GLY A 101 32.889 −5.910 17.550 1.00 46.79 O ATOM 761 N PRO A 102 33.384 −5.876 19.731 1.00 48.92 N ATOM 762 CA PRO A 102 34.197 −7.089 19.580 1.00 50.65 C ATOM 763 C PRO A 102 33.386 −8.302 19.135 1.00 51.50 C ATOM 764 O PRO A 102 32.262 −8.515 19.591 1.00 48.93 O ATOM 765 CB PRO A 102 34.835 −7.262 20.961 1.00 50.45 C ATOM 766 CG PRO A 102 33.891 −6.560 21.874 1.00 50.94 C ATOM 767 CD PRO A 102 33.488 −5.339 21.095 1.00 49.51 C ATOM 768 N ALA A 103 33.971 −9.080 18.229 1.00 54.06 N ATOM 769 CA ALA A 103 33.329 −10.270  17.676 1.00 57.29 C ATOM 770 C ALA A 103 32.886 −11.261  18.747 1.00 59.40 C ATOM 771 O ALA A 103 31.910 −11.985  18.565 1.00 60.71 O ATOM 772 CB ALA A 103 34.272 −10.957  16.685 1.00 57.06 C ATOM 773 N VAL A 104 33.605 −11.299  19.860 1.00 61.39 N ATOM 774 CA VAL A 104 33.252 −12.203  20.940 1.00 65.15 C ATOM 775 C VAL A 104 32.233 −11.493  21.841 1.00 66.48 C ATOM 776 O VAL A 104 31.973 −10.304  21.665 1.00 67.47 O ATOM 777 CB VAL A 104 34.511 −12.604  21.750 1.00 66.47 C ATOM 778 CG1 VAL A 104 34.972 −11.435  22.619 1.00 67.09 C ATOM 779 CG2 VAL A 104 34.225 −13.849  22.582 1.00 67.98 C ATOM 780 N SER A 105 31.657 −12.216  22.797 1.00 67.85 N ATOM 781 CA SER A 105 30.660 −11.638  23.697 1.00 69.86 C ATOM 782 C SER A 105 31.082 −10.268  24.238 1.00 71.04 C ATOM 783 O SER A 105 32.275 −9.976 24.353 1.00 71.90 O ATOM 784 CB SER A 105 30.386 −12.591  24.867 1.00 68.81 C ATOM 785 OG SER A 105 29.262 −12.156  25.614 1.00 65.88 O ATOM 786 N SER A 106 30.100 −9.431 24.570 1.00 71.39 N ATOM 787 CA SER A 106 30.394 −8.098 25.090 1.00 71.25 C ATOM 788 C SER A 106 29.433 −7.637 26.195 1.00 70.10 C ATOM 789 O SER A 106 29.501 −6.493 26.643 1.00 69.80 O ATOM 790 CB SER A 106 30.393 −7.081 23.944 1.00 71.68 C ATOM 791 OG SER A 106 30.968 −5.854 24.357 1.00 72.39 O ATOM 792 N GLY A 107 28.546 −8.530 26.629 1.00 68.65 N ATOM 793 CA GLY A 107 27.604 −8.198 27.688 1.00 65.20 C ATOM 794 C GLY A 107 26.628 −7.069 27.398 1.00 63.24 C ATOM 795 O GLY A 107 26.363 −6.232 28.262 1.00 62.37 O ATOM 796 N GLY A 108 26.086 −7.040 26.186 1.00 61.45 N ATOM 797 CA GLY A 108 25.137 −6.000 25.836 1.00 60.53 C ATOM 798 C GLY A 108 25.756 −4.634 25.579 1.00 59.27 C ATOM 799 O GLY A 108 25.053 −3.697 25.188 1.00 58.91 O ATOM 800 N ASP A 109 27.061 −4.506 25.808 1.00 56.39 N ATOM 801 CA ASP A 109 27.739 −3.238 25.573 1.00 53.46 C ATOM 802 C ASP A 109 27.481 −2.775 24.148 1.00 50.24 C ATOM 803 O ASP A 109 27.337 −3.589 23.237 1.00 49.64 O ATOM 804 CB ASP A 109 29.248 −3.381 25.789 1.00 54.43 C ATOM 805 CG ASP A 109 29.629 −3.407 27.253 1.00 55.56 C ATOM 806 OD1 ASP A 109 28.708 −3.414 28.101 1.00 56.20 O ATOM 807 OD2 ASP A 109 30.848 −3.420 27.550 1.00 54.70 O ATOM 808 N VAL A 110 7.4062 −1.461 23.971 1.00 47.84 N ATOM 809 CA VAL A 110 27.185 −0.851 22.658 1.00 44.51 C ATOM 810 C VAL A 110 28.009  0.429 22.615 1.00 41.04 C ATOM 811 O VAL A 110 27.969  1.230 23.541 1.00 39.49 O ATOM 812 CB VAL A 110 25.693 −0.488 22.425 1.00 44.38 C ATOM 813 CG1 VAL A 110 25.544  0.269 21.119 1.00 44.92 C ATOM 814 CG2 VAL A 110 24.842 −1.752 22.385 1.00 44.42 C ATOM 815 N THR A 111 28.768  0.611 21.544 1.00 38.79 N ATOM 816 CA THR A 111 29.593  1.797 21.406 1.00 34.46 C ATOM 817 C THR A 111 29.018  2.716 20.355 1.00 32.73 C ATOM 818 O THR A 111 28.788  2.310 19.224 1.00 29.50 O ATOM 819 CB THR A 111 31.024  1.439 21.000 1.00 34.45 C ATOM 820 OG1 THR A 111 31.602  0.604 22.012 1.00 37.92 O ATOM 821 CG2 THR A 111 31.873  2.704 20.849 1.00 34.66 C ATOM 822 N LEU A 112 28.767  3.957 20.746 1.00 31.45 N ATOM 823 CA LEU A 112 28.241  4.945 19.829 1.00 31.16 C ATOM 824 C LEU A 112 29.278  6.055 19.692 1.00 31.87 C ATOM 825 O LEU A 112 30.099  6.266 20.589 1.00 30.87 O ATOM 826 CB LEU A 112 26.928  5.515 20.362 1.00 31.16 C ATOM 827 CG LEU A 112 25.784  4.530 20.658 1.00 33.27 C ATOM 828 CD1 LEU A 112 24.524  5.323 21.052 1.00 30.61 C ATOM 829 CD2 LEU A 112 25.492  3.659 19.427 1.00 29.56 C ATOM 830 N GLN A 113 29.260  6.749 18.562 1.00 32.28 N ATOM 831 CA GLN A 113 30.194  7.850 18.342 1.00 31.23 C ATOM 832 C GLN A 113 29.418  9.129 18.098 1.00 29.93 C ATOM 833 O GLN A 113 28.521  9.173 17.248 1.00 28.95 O ATOM 834 CB GLN A 113 31.094  7.570 17.135 1.00 32.30 C ATOM 835 CG GLN A 113 32.126  8.661 16.852 1.00 34.40 C ATOM 836 CD GLN A 113 32.968  8.363 15.616 1.00 37.32 C ATOM 837 OE1 GLN A 113 32.632  8.774 14.505 1.00 40.75 O ATOM 838 NE2 GLN A 113 34.056  7.629 15.804 1.00 38.14 N ATOM 839 N CYS A 114 29.747 10.162 18.863 1.00 30.63 N ATOM 840 CA CYS A 114 29.101 11.452 18.707 1.00 34.04 C ATOM 841 C CYS A 114 30.154 12.345 18.069 1.00 36.19 C ATOM 842 O CYS A 114 30.998 12.912 18.759 1.00 35.54 O ATOM 843 CB CYS A 114 28.657 12.003 20.060 1.00 33.21 C ATOM 844 SG CYS A 114 27.592 13.482 19.911 1.00 34.65 S ATOM 845 N GLN A 115 30.098 12.455 16.745 1.00 39.55 N ATOM 846 CA GLN A 115 31.081 13.223 15.991 1.00 44.93 C ATOM 847 C GLN A 115 30.691 14.617 15.553 1.00 46.86 C ATOM 848 O GLN A 115 29.678 14.819 14.893 1.00 46.91 O ATOM 849 CB GLN A 115 31.524 12.426 14.761 1.00 47.47 C ATOM 850 CG GLN A 115 32.404 13.202 13.795 1.00 51.63 C ATOM 851 CD GLN A 115 32.736 12.404 12.547 1.00 54.20 C ATOM 852 OE1 GLN A 115 33.584 11.509 12.574 1.00 56.59 O ATOM 853 NE2 GLN A 115 32.056 12.714 11.447 1.00 53.04 N ATOM 854 N THR A 116 31.534 15.570 15.923 1.00 50.64 N ATOM 855 CA THR A 116 31.356 16.974 15.581 1.00 55.43 C ATOM 856 C THR A 116 32.749 17.463 15.195 1.00 58.52 C ATOM 857 O THR A 116 33.718 16.724 15.353 1.00 59.65 O ATOM 858 CB THR A 116 30.840 17.768 16.796 1.00 56.06 C ATOM 859 OG1 THR A 116 30.726 19.154 16.449 1.00 58.03 O ATOM 860 CG2 THR A 116 31.783 17.605 17.979 1.00 52.57 C ATOM 861 N ARG A 117 32.878 18.681 14.683 1.00 63.02 N ATOM 862 CA ARG A 117 34.215 19.144 14.324 1.00 67.76 C ATOM 863 C ARG A 117 34.647 20.430 15.021 1.00 68.99 C ATOM 864 O ARG A 117 35.822 20.805 14.960 1.00 70.47 O ATOM 865 CB ARG A 117 34.351 19.298 12.801 1.00 70.81 C ATOM 866 CG ARG A 117 35.809 19.302 12.334 1.00 74.35 C ATOM 867 CD ARG A 117 35.963 18.991 10.850 1.00 76.88 C ATOM 868 NE ARG A 117 37.378 18.921 10.476 1.00 80.96 N ATOM 869 CZ ARG A 117 37.832 18.668 9.248 1.00 81.03 C ATOM 870 NH1 ARG A 117 36.985 18.454 8.248 1.00 81.45 N ATOM 871 NH2 ARG A 117 39.140 18.638 9.020 1.00 79.59 N ATOM 872 N TYR A 118 33.707 21.092 15.694 1.00 69.11 N ATOM 873 CA TYR A 118 33.997 22.338 16.410 1.00 68.84 C ATOM 874 C TYR A 118 35.221 22.214 17.327 1.00 68.24 C ATOM 875 O TYR A 118 35.807 23.217 17.737 1.00 69.13 O ATOM 876 CB TYR A 118 32.789 22.760 17.259 1.00 68.53 C ATOM 877 CG TYR A 118 31.623 23.364 16.494 1.00 68.16 C ATOM 878 CD1 TYR A 118 31.728 24.620 15.898 1.00 66.95 C ATOM 879 CD2 TYR A 118 30.396 22.699 16.414 1.00 67.66 C ATOM 880 CE1 TYR A 118 30.636 25.203 15.249 1.00 66.11 C ATOM 881 CE2 TYR A 118 29.302 23.270 15.766 1.00 66.16 C ATOM 882 CZ TYR A 118 29.426 24.522 15.188 1.00 65.72 C ATOM 883 OH TYR A 118 28.337 25.095 14.564 1.00 63.03 O ATOM 884 N GLY A 119 35.602 20.983 17.647 1.00 67.26 N ATOM 885 CA GLY A 119 36.730 20.770 18.535 1.00 64.40 C ATOM 886 C GLY A 119 36.262 20.702 19.982 1.00 62.33 C ATOM 887 O GLY A 119 37.064 20.843 20.910 1.00 64.13 O ATOM 888 N PHE A 120 34.961 20.483 20.175 1.00 57.70 N ATOM 889 CA PHE A 120 34.374 20.402 21.510 1.00 52.21 C ATOM 890 C PHE A 120 34.933 19.244 22.323 1.00 48.15 C ATOM 891 O PHE A 120 35.418 18.265 21.766 1.00 48.97 O ATOM 892 CB PHE A 120 32.853 20.288 21.411 1.00 52.96 C ATOM 893 CG PHE A 120 32.190 21.521 20.869 1.00 54.64 C ATOM 894 CD1 PHE A 120 32.790 22.773 21.010 1.00 55.67 C ATOM 895 CD2 PHE A 120 30.950 21.442 20.244 1.00 57.25 C ATOM 896 CE1 PHE A 120 32.160 23.930 20.534 1.00 57.52 C ATOM 897 CE2 PHE A 120 30.308 22.592 19.764 1.00 57.97 C ATOM 898 CZ PHE A 120 30.915 23.839 19.910 1.00 58.31 C ATOM 899 N ASP A 121 34.849 19.351 23.644 1.00 44.10 N ATOM 900 CA ASP A 121 35.395 18.323 24.521 1.00 41.01 C ATOM 901 C ASP A 121 34.387 17.727 25.498 1.00 39.84 C ATOM 902 O ASP A 121 34.764 17.128 26.499 1.00 41.13 O ATOM 903 CB ASP A 121 36.562 18.909 25.310 1.00 38.52 C ATOM 904 CG ASP A 121 36.104 19.897 26.362 1.00 38.95 C ATOM 905 OD1 ASP A 121 34.940 20.359 26.271 1.00 38.56 O ATOM 906 OD2 ASP A 121 36.904 20.216 27.271 1.00 37.45 O ATOM 907 N GLN A 122 33.107 17.891 25.228 1.00 37.82 N ATOM 908 CA GLN A 122 32.110 17.331 26.120 1.00 38.02 C ATOM 909 C GLN A 122 30.958 16.787 25.292 1.00 38.39 C ATOM 910 O GLN A 122 30.546 17.398 24.307 1.00 40.52 O ATOM 911 CB GLN A 122 31.634 18.397 27.105 1.00 39.33 C ATOM 912 CG GLN A 122 32.675 18.761 28.157 1.00 40.99 C ATOM 913 CD GLN A 122 32.769 17.720 29.260 1.00 43.10 C ATOM 914 OE1 GLN A 122 31.898 17.641 30.127 1.00 47.15 O ATOM 915 NE2 GLN A 122 33.815 16.907 29.224 1.00 42.14 N ATOM 916 N PHE A 123 30.449 15.628 25.684 1.00 36.42 N ATOM 917 CA PHE A 123 29.370 15.004 24.948 1.00 36.68 C ATOM 918 C PHE A 123 28.305 14.455 25.873 1.00 36.67 C ATOM 919 O PHE A 123 28.605 13.856 26.896 1.00 37.81 O ATOM 920 CB PHE A 123 29.924 13.875 24.074 1.00 36.21 C ATOM 921 CG PHE A 123 31.104 14.286 23.238 1.00 36.09 C ATOM 922 CD1 PHE A 123 32.376 14.377 23.803 1.00 34.80 C ATOM 923 CD2 PHE A 123 30.937 14.638 21.899 1.00 35.65 C ATOM 924 CE1 PHE A 123 33.465 14.813 23.055 1.00 31.85 C ATOM 925 CE2 PHE A 123 32.018 15.075 21.142 1.00 34.13 C ATOM 926 CZ PHE A 123 33.284 15.163 21.723 1.00 34.38 C ATOM 927 N ALA A 124 27.051 14.666 25.510 1.00 35.78 N ATOM 928 CA ALA A 124 25.961 14.161 26.314 1.00 35.02 C ATOM 929 C ALA A 124 25.133 13.272 25.417 1.00 34.92 C ATOM 930 O ALA A 124 24.517 13.732 24.465 1.00 35.69 O ATOM 931 CB ALA A 124 25.118 15.312 26.844 1.00 35.11 C ATOM 932 N LEU A 125 25.128 11.989 25.716 1.00 33.89 N ATOM 933 CA LEU A 125 24.367 11.038 24.924 1.00 35.58 C ATOM 934 C LEU A 125 23.135 10.606 25.704 1.00 37.95 C ATOM 935 O LEU A 125 23.199 10.420 26.926 1.00 37.76 O ATOM 936 CB LEU A 125 25.236  9.817 24.619 1.00 33.63 C ATOM 937 CG LEU A 125 24.523  8.567 24.119 1.00 34.49 C ATOM 938 CD1 LEU A 125 23.913  8.815 22.750 1.00 34.80 C ATOM 939 CD2 LEU A 125 25.529  7.427 24.054 1.00 35.30 C ATOM 940 N TYR A 126 22.003 10.458 25.026 1.00 38.39 N ATOM 941 CA TYR A 126 20.827 10.014 25.753 1.00 40.68 C ATOM 942 C TYR A 126 19.834  9.172 24.967 1.00 40.47 C ATOM 943 O TYR A 126 19.668  9.305 23.754 1.00 39.03 O ATOM 944 CB TYR A 126 20.107 11.203 26.416 1.00 40.84 C ATOM 945 CG TYR A 126 19.072 11.907 25.562 1.00 43.26 C ATOM 946 CD1 TYR A 126 19.443 12.682 24.467 1.00 44.00 C ATOM 947 CD2 TYR A 126 17.714 11.802 25.861 1.00 45.53 C ATOM 948 CE1 TYR A 126 18.485 13.336 23.689 1.00 45.48 C ATOM 949 CE2 TYR A 126 16.749 12.450 25.095 1.00 45.13 C ATOM 950 CZ TYR A 126 17.139 13.214 24.011 1.00 45.98 C ATOM 951 OH TYR A 126 16.182 13.842 23.240 1.00 47.24 O ATOM 952 N LYS A 127 19.207  8.263 25.696 1.00 43.00 N ATOM 953 CA LYS A 127 18.191  7.389 25.153 1.00 45.17 C ATOM 954 C LYS A 127 16.863  8.022 25.551 1.00 47.19 C ATOM 955 O LYS A 127 16.598  8.234 26.735 1.00 44.93 O ATOM 956 CB LYS A 127 18.287  5.996 25.769 1.00 44.85 C ATOM 957 CG LYS A 127 17.015  5.186 25.584 1.00 44.80 C ATOM 958 CD LYS A 127 16.901  4.076 26.601 1.00 45.02 C ATOM 959 CE LYS A 127 15.439  3.818 26.925 1.00 47.23 C ATOM 960 NZ LYS A 127 14.764  5.050 27.451 1.00 46.07 N ATOM 961 N GLU A 128 16.048  8.342 24.555 1.00 50.47 N ATOM 962 CA GLU A 128 14.747  8.929 24.802 1.00 55.42 C ATOM 963 C GLU A 128 13.895  7.966 25.616 1.00 57.21 C ATOM 964 O GLU A 128 13.965  6.747 25.435 1.00 56.72 O ATOM 965 CB GLU A 128 14.043  9.231 23.481 1.00 56.79 C ATOM 966 CG GLU A 128 14.542 10.477 22.780 1.00 61.95 C ATOM 967 CD GLU A 128 13.968 10.609 21.386 1.00 64.50 C ATOM 968 OE1 GLU A 128 12.779 10.257 21.206 1.00 64.51 O ATOM 969 OE2 GLU A 128 14.702 11.067 20.478 1.00 64.33 O ATOM 970 N GLY A 129 13.097  8.525 26.515 1.00 59.19 N ATOM 971 CA GLY A 129 12.226  7.709 27.327 1.00 63.88 C ATOM 972 C GLY A 129 10.802  7.873 26.839 1.00 67.81 C ATOM 973 O GLY A 129 10.244  8.967 26.903 1.00 69.11 O ATOM 974 N ASP A 130 10.218  6.792 26.335 1.00 70.85 N ATOM 975 CA ASP A 130 8.844  6.823 25.844 1.00 73.82 C ATOM 976 C ASP A 130 7.843  6.884 27.004 1.00 75.00 C ATOM 977 O ASP A 130 8.124  6.408 28.105 1.00 74.29 O ATOM 978 CB ASP A 130 8.571  5.588 24.974 1.00 74.95 C ATOM 979 CG ASP A 130 9.288  4.344 25.481 1.00 76.54 C ATOM 980 OD1 ASP A 130 10.534  4.292 25.380 1.00 76.21 O ATOM 981 OD2 ASP A 130 8.609  3.421 25.984 1.00 77.14 O ATOM 982 N PRO A 131 6.664  7.491 26.772 1.00 76.14 N ATOM 983 CA PRO A 131 5.620  7.614 27.795 1.00 76.71 C ATOM 984 C PRO A 131 4.814  6.327 28.001 1.00 77.71 C ATOM 985 O PRO A 131 5.099  5.298 27.380 1.00 77.97 O ATOM 986 CB PRO A 131 4.766  8.762 27.266 1.00 76.62 C ATOM 987 CG PRO A 131 4.841  8.560 25.794 1.00 75.47 C ATOM 988 CD PRO A 131 6.306  8.269 25.571 1.00 75.94 C ATOM 989 N ALA A 132 3.813  6.395 28.880 1.00 78.98 N ATOM 990 CA ALA A 132 2.949  5.250 29.181 1.00 79.98 C ATOM 991 C ALA A 132 1.948  5.007 28.050 1.00 80.88 C ATOM 992 O ALA A 132 1.711  5.892 27.221 1.00 81.43 O ATOM 993 CB ALA A 132 2.209  5.491 30.492 1.00 79.92 C ATOM 994 N PRO A 133 1.307  3.823 28.019 1.00 81.31 N ATOM 995 CA PRO A 133 1.366  2.646 28.899 1.00 81.90 C ATOM 996 C PRO A 133 2.703  1.905 28.969 1.00 82.36 C ATOM 997 O PRO A 133 2.734  0.701 29.242 1.00 82.84 O ATOM 998 CB PRO A 133 0.265  1.739 28.341 1.00 81.84 C ATOM 999 CG PRO A 133 −0.667  2.687 27.662 1.00 82.09 C ATOM 1000 CD PRO A 133 0.284  3.624 26.979 1.00 81.54 C ATOM 1001 N TYR A 134 3.803  2.613 28.738 1.00 81.85 N ATOM 1002 CA TYR A 134 5.116  1.980 28.767 1.00 81.17 C ATOM 1003 C TYR A 134 6.073  2.679 29.724 1.00 79.59 C ATOM 1004 O TYR A 134 6.902  2.035 30.369 1.00 79.58 O ATOM 1005 CB TYR A 134 5.676  1.955 27.349 1.00 82.82 C ATOM 1006 CG TYR A 134 4.700  1.323 26.383 1.00 83.68 C ATOM 1007 CD1 TYR A 134 4.486 −0.057 26.385 1.00 83.92 C ATOM 1008 CD2 TYR A 134 3.934  2.109 25.517 1.00 83.49 C ATOM 1009 CE1 TYR A 134 3.529 −0.641 25.552 1.00 83.81 C ATOM 1010 CE2 TYR A 134 2.973  1.535 24.680 1.00 82.91 C ATOM 1011 CZ TYR A 134 2.777  0.160 24.704 1.00 82.88 C ATOM 1012 OH TYR A 134 1.832 −0.417 23.886 1.00 81.06 O ATOM 1013 N LYS A 135 5.940  3.997 29.816 1.00 77.68 N ATOM 1014 CA LYS A 135 6.766  4.812 30.699 1.00 75.24 C ATOM 1015 C LYS A 135 8.186  4.280 30.830 1.00 73.74 C ATOM 1016 O LYS A 135 8.492  3.515 31.743 1.00 73.88 O ATOM 1017 CB LYS A 135 6.123  4.902 32.088 1.00 75.02 C ATOM 1018 CG LYS A 135 5.925  6.327 32.604 1.00 74.72 C ATOM 1019 CD LYS A 135 7.254  7.047 32.808 1.00 74.09 C ATOM 1020 CE LYS A 135 7.052  8.494 33.250 1.00 73.39 C ATOM 1021 NZ LYS A 135 6.342  8.617 34.554 1.00 71.23 N ATOM 1022 N ASN A 136 9.046  4.681 29.902 1.00 71.59 N ATOM 1023 CA ASN A 136 10.437  4.268 29.922 1.00 68.38 C ATOM 1024 C ASN A 136 11.234  5.510 30.276 1.00 65.84 C ATOM 1025 O ASN A 136 11.081  6.551 29.651 1.00 65.50 O ATOM 1026 CB ASN A 136 10.859  3.754 28.552 1.00 69.89 C ATOM 1027 CG ASN A 136 12.066  2.850 28.624 1.00 70.50 C ATOM 1028 OD1 ASN A 136 13.088  3.199 29.219 1.00 71.47 O ATOM 1029 ND2 ASN A 136 11.958  1.678 28.013 1.00 71.37 N ATOM 1030 N PRO A 137 12.104  5.417 31.281 1.00 64.28 N ATOM 1031 CA PRO A 137 12.903  6.576 31.685 1.00 61.92 C ATOM 1032 C PRO A 137 13.966  6.963 30.677 1.00 58.77 C ATOM 1033 O PRO A 137 14.429  6.124 29.900 1.00 57.09 O ATOM 1034 CB PRO A 137 13.533  6.107 32.986 1.00 63.33 C ATOM 1035 CG PRO A 137 13.825  4.660 32.671 1.00 64.28 C ATOM 1036 CD PRO A 137 12.518  4.211 32.023 1.00 64.36 C ATOM 1037 N GLU A 138 14.338  8.242 30.687 1.00 56.31 N ATOM 1038 CA GLU A 138 15.405  8.719 29.818 1.00 53.37 C ATOM 1039 C GLU A 138 16.657  8.212 30.513 1.00 51.27 C ATOM 1040 O GLU A 138 16.657  8.008 31.729 1.00 51.66 O ATOM 1041 CB GLU A 138 15.492 10.249 29.770 1.00 52.56 C ATOM 1042 CG GLU A 138 14.350 10.981 29.107 1.00 54.93 C ATOM 1043 CD GLU A 138 14.743 12.400 28.704 1.00 56.83 C ATOM 1044 OE1 GLU A 138 15.460 13.066 29.481 1.00 57.06 O ATOM 1045 OE2 GLU A 138 14.332 12.855 27.612 1.00 57.94 O ATOM 1046 N ARG A 139 17.715  8.001 29.748 1.00 49.57 N ATOM 1047 CA ARG A 139 18.970  7.544 30.312 1.00 47.63 C ATOM 1048 C ARG A 139 20.076  8.385 29.710 1.00 45.43 C ATOM 1049 O ARG A 139 20.325  8.333 28.510 1.00 45.40 O ATOM 1050 CB ARG A 139 19.174  6.065 30.008 1.00 49.79 C ATOM 1051 CG ARG A 139 18.146  5.196 30.702 1.00 53.91 C ATOM 1052 CD ARG A 139 18.157  3.777 30.177 1.00 58.48 C ATOM 1053 NE ARG A 139 17.145  2.960 30.842 1.00 63.23 N ATOM 1054 CZ ARG A 139 17.150  2.684 32.143 1.00 65.59 C ATOM 1055 NH1 ARG A 139 18.118  3.162 32.921 1.00 65.48 N ATOM 1056 NH2 ARG A 139 16.188  1.930 32.666 1.00 65.15 N ATOM 1057 N TRP A 140 20.716  9.184 30.554 1.00 43.40 N ATOM 1058 CA TRP A 140 21.791 10.055 30.119 1.00 40.75 C ATOM 1059 C TRP A 140 23.183  9.446 30.282 1.00 39.92 C ATOM 1060 O TRP A 140 23.439  8.667 31.200 1.00 39.08 O ATOM 1061 CB TRP A 140 21.699 11.393 30.858 1.00 40.25 C ATOM 1062 CG TRP A 140 20.565 12.218 30.361 1.00 41.67 C ATOM 1063 CD1 TRP A 140 19.252 12.142 30.751 1.00 39.88 C ATOM 1064 CD2 TRP A 140 20.607 13.152 29.274 1.00 41.67 C ATOM 1065 NE1 TRP A 140 18.476 12.962 29.966 1.00 40.11 N ATOM 1066 CE2 TRP A 140 19.279 13.594 29.050 1.00 41.25 C ATOM 1067 CE3 TRP A 140 21.640 13.653 28.458 1.00 41.06 C ATOM 1068 CZ2 TRP A 140 18.955 14.515 28.044 1.00 39.75 C ATOM 1069 CZ3 TRP A 140 21.319 14.567 27.456 1.00 39.51 C ATOM 1070 CH2 TRP A 140 19.984 14.987 27.259 1.00 41.49 C ATOM 1071 N TYR A 141 24.072  9.821 29.368 1.00 39.14 N ATOM 1072 CA TYR A 141 25.446  9.352 29.340 1.00 37.18 C ATOM 1073 C TYR A 141 26.339 10.524 28.989 1.00 37.42 C ATOM 1074 O TYR A 141 26.165 11.150 27.949 1.00 40.57 O ATOM 1075 CB TYR A 141 25.583  8.277 28.276 1.00 38.05 C ATOM 1076 CG TYR A 141 24.740  7.070 28.559 1.00 39.37 C ATOM 1077 CD1 TYR A 141 25.049  6.229 29.621 1.00 39.49 C ATOM 1078 CD2 TYR A 141 23.609  6.786 27.799 1.00 38.61 C ATOM 1079 CE1 TYR A 141 24.257  5.140 29.922 1.00 40.45 C ATOM 1080 CE2 TYR A 141 22.807  5.696 28.095 1.00 39.59 C ATOM 1081 CZ TYR A 141 23.140  4.876 29.161 1.00 40.84 C ATOM 1082 OH TYR A 141 22.363  3.789 29.484 1.00 43.71 O ATOM 1083 N ARG A 142 27.300 10.832 29.842 1.00 38.22 N ATOM 1084 CA ARG A 142 28.186 11.951 29.559 1.00 39.57 C ATOM 1085 C ARG A 142 29.611 11.453 29.389 1.00 37.41 C ATOM 1086 O ARG A 142 30.044 10.561 30.104 1.00 40.52 O ATOM 1087 CB ARG A 142 28.094 12.972 30.696 1.00 45.76 C ATOM 1088 CG ARG A 142 28.655 14.359 30.386 1.00 52.24 C ATOM 1089 CD ARG A 142 27.944 15.400 31.245 1.00 57.25 C ATOM 1090 NE ARG A 142 28.747 16.594 31.498 1.00 60.32 N ATOM 1091 CZ ARG A 142 28.290 17.673 32.130 1.00 62.56 C ATOM 1092 NH1 ARG A 142 27.033 17.707 32.565 1.00 62.55 N ATOM 1093 NH2 ARG A 142 29.092 18.712 32.342 1.00 63.25 N ATOM 1094 N ALA A 143 30.331 12.009 28.424 1.00 35.00 N ATOM 1095 CA ALA A 143 31.711 11.608 28.179 1.00 34.15 C ATOM 1096 C ALA A 143 32.581 12.811 27.822 1.00 34.01 C ATOM 1097 O ALA A 143 32.084 13.846 27.376 1.00 32.26 O ATOM 1098 CB ALA A 143 31.771 10.571 27.065 1.00 33.88 C ATOM 1099 N SER A 144 33.886 12.664 28.026 1.00 33.61 N ATOM 1100 CA SER A 144 34.836 13.730 27.731 1.00 34.57 C ATOM 1101 C SER A 144 35.482 13.478 26.378 1.00 33.54 C ATOM 1102 O SER A 144 36.471 14.127 26.016 1.00 33.18 O ATOM 1103 CB SER A 144 35.913 13.797 28.817 1.00 34.41 C ATOM 1104 OG SER A 144 35.352 14.206 30.051 1.00 38.94 O ATOM 1105 N PHE A 145 34.920 12.518 25.649 1.00 30.61 N ATOM 1106 CA PHE A 145 35.399 12.157 24.323 1.00 31.20 C ATOM 1107 C PHE A 145 34.216 11.645 23.493 1.00 30.37 C ATOM 1108 O PHE A 145 33.271 11.088 24.038 1.00 31.72 O ATOM 1109 CB PHE A 145 36.532 11.124 24.427 1.00 30.76 C ATOM 1110 CG PHE A 145 36.544 10.364 25.718 1.00 30.44 C ATOM 1111 CD1 PHE A 145 35.525  9.469 26.025 1.00 29.77 C ATOM 1112 CD2 PHE A 145 37.574 10.546 26.630 1.00 31.35 C ATOM 1113 CE1 PHE A 145 35.534  8.772 27.219 1.00 26.54 C ATOM 1114 CE2 PHE A 145 37.593  9.849 27.830 1.00 30.53 C ATOM 1115 CZ PHE A 145 36.571  8.961 28.123 1.00 30.11 C ATOM 1116 N PRO A 146 34.261 11.828 22.159 1.00 31.31 N ATOM 1117 CA PRO A 146 33.206 11.422 21.221 1.00 31.52 C ATOM 1118 C PRO A 146 32.816  9.957 21.126 1.00 32.34 C ATOM 1119 O PRO A 146 31.737  9.642 20.649 1.00 33.45 O ATOM 1120 CB PRO A 146 33.709 11.965 19.888 1.00 30.08 C ATOM 1121 CG PRO A 146 35.176 11.781 20.011 1.00 29.98 C ATOM 1122 CD PRO A 146 35.466 12.252 21.420 1.00 30.27 C ATOM 1123 N ILE A 147 33.681  9.052 21.553 1.00 33.80 N ATOM 1124 CA ILE A 147 33.329  7.645 21.466 1.00 34.25 C ATOM 1125 C ILE A 147 32.887  7.115 22.832 1.00 35.43 C ATOM 1126 O ILE A 147 33.669  7.076 23.787 1.00 35.48 O ATOM 1127 CB ILE A 147 34.507  6.849 20.873 1.00 33.47 C ATOM 1128 CG1 ILE A 147 34.747  7.352 19.442 1.00 32.17 C ATOM 1129 CG2 ILE A 147 34.208  5.345 20.896 1.00 33.09 C ATOM 1130 CD1 ILE A 147 35.916  6.709 18.712 1.00 31.86 C ATOM 1131 N ILE A 148 31.619  6.713 22.907 1.00 35.31 N ATOM 1132 CA ILE A 148 31.033  6.231 24.151 1.00 36.97 C ATOM 1133 C ILE A 148 30.448  4.821 24.101 1.00 36.51 C ATOM 1134 O ILE A 148 29.607  4.511 23.259 1.00 37.91 O ATOM 1135 CB ILE A 148 29.906  7.183 24.604 1.00 39.00 C ATOM 1136 CG1 ILE A 148 30.394  8.628 24.563 1.00 41.02 C ATOM 1137 CG2 ILE A 148 29.455  6.840 26.002 1.00 38.82 C ATOM 1138 CD1 ILE A 148 29.267  9.634 24.725 1.00 43.91 C ATOM 1139 N THR A 149 30.878  3.975 25.027 1.00 35.37 N ATOM 1140 CA THR A 149 30.377  2.614 25.100 1.00 36.42 C ATOM 1141 C THR A 149 29.272  2.539 26.132 1.00 38.18 C ATOM 1142 O THR A 149 29.479  2.886 27.289 1.00 41.96 O ATOM 1143 CB THR A 149 31.469  1.625 25.522 1.00 35.18 C ATOM 1144 OG1 THR A 149 32.478  1.566 24.508 1.00 37.20 O ATOM 1145 CG2 THR A 149 30.876  0.236 25.725 1.00 35.81 C ATOM 1146 N VAL A 150 28.095  2.093 25.721 1.00 39.70 N ATOM 1147 CA VAL A 150 26.984  1.971 26.652 1.00 41.38 C ATOM 1148 C VAL A 150 26.886  0.518 27.095 1.00 43.32 C ATOM 1149 O VAL A 150 26.596 −0.369 26.291 1.00 43.29 O ATOM 1150 CB VAL A 150 25.649  2.400 26.010 1.00 41.16 C ATOM 1151 CG1 VAL A 150 24.512  2.194 27.004 1.00 37.79 C ATOM 1152 CG2 VAL A 150 25.727  3.866 25.581 1.00 38.75 C ATOM 1153 N THR A 151 27.147  0.284 28.377 1.00 46.15 N ATOM 1154 CA THR A 151 27.105 −1.061 28.934 1.00 48.28 C ATOM 1155 C THR A 151 25.673 −1.555 29.044 1.00 47.82 C ATOM 1156 O THR A 151 24.794 −0.834 29.520 1.00 47.53 O ATOM 1157 CB THR A 151 27.777 −1.098 30.321 1.00 49.34 C ATOM 1158 OG1 THR A 151 27.266 −0.027 31.124 1.00 51.82 O ATOM 1159 CG2 THR A 151 29.292 −0.928 30.182 1.00 50.70 C ATOM 1160 N ALA A 152 25.447 −2.783 28.584 1.00 48.69 N ATOM 1161 CA ALA A 152 24.122 −3.391 28.620 1.00 48.78 C ATOM 1162 C ALA A 152 23.109 −2.343 28.179 1.00 48.57 C ATOM 1163 O ALA A 152 22.193 −1.983 28.922 1.00 48.02 O ATOM 1164 CB ALA A 152 23.812 −3.876 30.035 1.00 48.90 C ATOM 1165 N ALA A 153 23.294 −1.849 26.960 1.00 48.11 N ATOM 1166 CA ALA A 153 22.424 −0.822 26.412 1.00 47.17 C ATOM 1167 C ALA A 153 20.991 −1.298 26.231 1.00 47.15 C ATOM 1168 O ALA A 153 20.743 −2.442 25.841 1.00 43.93 O ATOM 1169 CB ALA A 153 22.978 −0.327 25.087 1.00 45.52 C ATOM 1170 N HIS A 154 20.053 −0.403 26.528 1.00 47.04 N ATOM 1171 CA HIS A 154 18.636 −0.698 26.388 1.00 47.98 C ATOM 1172 C HIS A 154 18.189 −0.279 24.998 1.00 46.98 C ATOM 1173 O HIS A 154 18.701  0.696 24.447 1.00 47.17 O ATOM 1174 CB HIS A 154 17.818  0.084 27.423 1.00 49.75 C ATOM 1175 CG HIS A 154 18.102 −0.304 28.841 1.00 52.68 C ATOM 1176 ND1 HIS A 154 17.717 −1.515 29.372 1.00 53.39 N ATOM 1177 CD2 HIS A 154 18.745  0.355 29.833 1.00 52.52 C ATOM 1178 CE1 HIS A 154 18.111 −1.584 30.632 1.00 54.90 C ATOM 1179 NE2 HIS A 154 18.737 −0.462 30.936 1.00 51.96 N ATOM 1180 N SER A 155 17.246 −1.020 24.428 1.00 44.32 N ATOM 1181 CA SER A 155 16.714 −0.674 23.119 1.00 41.98 C ATOM 1182 C SER A 155 16.073  0.700 23.246 1.00 40.45 C ATOM 1183 O SER A 155 15.484  1.024 24.275 1.00 39.06 O ATOM 1184 CB SER A 155 15.648 −1.679 22.688 1.00 41.32 C ATOM 1185 OG SER A 155 16.212 −2.947 22.436 1.00 41.20 O ATOM 1186 N GLY A 156 16.190  1.515 22.203 1.00 40.20 N ATOM 1187 CA GLY A 156 15.592  2.834 22.261 1.00 36.66 C ATOM 1188 C GLY A 156 16.134  3.784 21.215 1.00 36.30 C ATOM 1189 O GLY A 156 16.962  3.410 20.388 1.00 33.59 O ATOM 1190 N THR A 157 15.647  5.020 21.264 1.00 34.60 N ATOM 1191 CA THR A 157 16.066  6.059 20.349 1.00 33.87 C ATOM 1192 C THR A 157 17.138  6.880 21.043 1.00 33.63 C ATOM 1193 O THR A 157 16.934  7.364 22.156 1.00 29.86 O ATOM 1194 CB THR A 157 14.901  6.982 20.005 1.00 34.28 C ATOM 1195 OG1 THR A 157 13.839  6.206 19.450 1.00 35.53 O ATOM 1196 CG2 THR A 157 15.339  8.044 19.006 1.00 34.53 C ATOM 1197 N TYR A 158 18.279  7.044 20.382 1.00 33.94 N ATOM 1198 CA TYR A 158 19.376  7.800 20.970 1.00 34.34 C ATOM 1199 C TYR A 158 19.707  9.074 20.206 1.00 34.29 C ATOM 1200 O TYR A 158 19.522  9.150 18.997 1.00 36.03 O ATOM 1201 CB TYR A 158 20.627  6.931 21.049 1.00 34.08 C ATOM 1202 CG TYR A 158 20.557  5.809 22.057 1.00 35.09 C ATOM 1203 CD1 TYR A 158 19.676  4.741 21.889 1.00 36.16 C ATOM 1204 CD2 TYR A 158 21.410  5.794 23.156 1.00 36.44 C ATOM 1205 CE1 TYR A 158 19.653  3.681 22.786 1.00 37.45 C ATOM 1206 CE2 TYR A 158 21.398  4.746 24.060 1.00 38.59 C ATOM 1207 CZ TYR A 158 20.525  3.688 23.870 1.00 40.56 C ATOM 1208 OH TYR A 158 20.572  2.618 24.744 1.00 43.47 O ATOM 1209 N ARG A 159 20.195 10.073 20.930 1.00 33.49 N ATOM 1210 CA ARG A 159 20.593 11.340 20.337 1.00 34.57 C ATOM 1211 C ARG A 159 21.716 11.853 21.207 1.00 34.13 C ATOM 1212 O ARG A 159 21.809 11.482 22.369 1.00 33.01 O ATOM 1213 CB ARG A 159 19.441 12.341 20.357 1.00 35.99 C ATOM 1214 CG ARG A 159 18.302 12.034 19.395 1.00 38.36 C ATOM 1215 CD ARG A 159 17.155 12.986 19.632 1.00 40.80 C ATOM 1216 NE ARG A 159 16.031 12.720 18.750 1.00 49.08 N ATOM 1217 CZ ARG A 159 15.894 13.242 17.535 1.00 54.07 C ATOM 1218 NH1 ARG A 159 16.819 14.070 17.050 1.00 53.77 N ATOM 1219 NH2 ARG A 159 14.827 12.933 16.804 1.00 55.63 N ATOM 1220 N CYS A 160 22.570 12.705 20.656 1.00 34.26 N ATOM 1221 CA CYS A 160 23.670 13.244 21.440 1.00 32.33 C ATOM 1222 C CYS A 160 23.865 14.726 21.175 1.00 31.75 C ATOM 1223 O CYS A 160 23.377 15.273 20.169 1.00 30.91 O ATOM 1224 CB CYS A 160 24.976 12.474 21.155 1.00 32.71 C ATOM 1225 SG CYS A 160 25.732 12.729 19.510 1.00 37.58 S ATOM 1226 N TYR A 161 24.576 15.364 22.104 1.00 29.38 N ATOM 1227 CA TYR A 161 24.896 16.782 22.043 1.00 26.89 C ATOM 1228 C TYR A 161 26.372 16.926 22.314 1.00 25.54 C ATOM 1229 O TYR A 161 26.945 16.146 23.068 1.00 25.45 O ATOM 1230 CB TYR A 161 24.187 17.576 23.138 1.00 26.43 C ATOM 1231 CG TYR A 161 22.696 17.546 23.112 1.00 29.65 C ATOM 1232 CD1 TYR A 161 21.987 16.454 23.633 1.00 27.22 C ATOM 1233 CD2 TYR A 161 21.974 18.639 22.616 1.00 28.67 C ATOM 1234 CE1 TYR A 161 20.598 16.458 23.668 1.00 27.33 C ATOM 1235 CE2 TYR A 161 20.589 18.650 22.644 1.00 28.77 C ATOM 1236 CZ TYR A 161 19.906 17.563 23.168 1.00 30.33 C ATOM 1237 OH TYR A 161 18.528 17.584 23.172 1.00 33.99 O ATOM 1238 N SER A 162 26.981 17.944 21.725 1.00 26.05 N ATOM 1239 CA SER A 162 28.391 18.202 21.962 1.00 29.18 C ATOM 1240 C SER A 162 28.505 19.627 22.459 1.00 30.26 C ATOM 1241 O SER A 162 27.682 20.480 22.117 1.00 31.81 O ATOM 1242 CB SER A 162 29.206 18.063 20.686 1.00 28.23 C ATOM 1243 OG SER A 162 29.006 19.183 19.839 1.00 34.19 O ATOM 1244 N PHE A 163 29.514 19.878 23.280 1.00 32.26 N ATOM 1245 CA PHE A 163 29.738 21.206 23.809 1.00 33.82 C ATOM 1246 C PHE A 163 31.105 21.304 24.440 1.00 35.42 C ATOM 1247 O PHE A 163 31.805 20.309 24.583 1.00 36.76 O ATOM 1248 CB PHE A 163 28.659 21.602 24.829 1.00 33.09 C ATOM 1249 CG PHE A 163 28.608 20.736 26.062 1.00 32.65 C ATOM 1250 CD1 PHE A 163 27.852 19.565 26.081 1.00 34.62 C ATOM 1251 CD2 PHE A 163 29.233 21.146 27.240 1.00 32.10 C ATOM 1252 CE1 PHE A 163 27.709 18.817 27.262 1.00 34.01 C ATOM 1253 CE2 PHE A 163 29.099 20.412 28.426 1.00 30.01 C ATOM 1254 CZ PHE A 163 28.336 19.250 28.440 1.00 33.04 C ATOM 1255 N SER A 164 31.471 22.522 24.813 1.00 38.01 N ATOM 1256 CA SER A 164 32.761 22.817 25.407 1.00 38.05 C ATOM 1257 C SER A 164 32.683 23.024 26.911 1.00 40.11 C ATOM 1258 O SER A 164 31.719 23.603 27.424 1.00 38.23 O ATOM 1259 CB SER A 164 33.340 24.063 24.751 1.00 36.65 C ATOM 1260 OG SER A 164 34.231 24.713 25.632 1.00 44.07 O ATOM 1261 N SER A 165 33.711 22.552 27.612 1.00 40.90 N ATOM 1262 CA SER A 165 33.777 22.687 29.064 1.00 43.06 C ATOM 1263 C SER A 165 33.951 24.146 29.474 1.00 43.08 C ATOM 1264 O SER A 165 33.824 24.486 30.640 1.00 44.41 O ATOM 1265 CB SER A 165 34.931 21.849 29.614 1.00 42.13 C ATOM 1266 OG SER A 165 36.142 22.175 28.960 1.00 42.79 O ATOM 1267 N ARG A 166 34.242 24.995 28.498 1.00 45.93 N ATOM 1268 CA ARG A 166 34.431 26.428 28.703 1.00 48.47 C ATOM 1269 C ARG A 166 33.076 27.132 28.890 1.00 47.71 C ATOM 1270 O ARG A 166 32.975 28.142 29.584 1.00 47.37 O ATOM 1271 CB ARG A 166 35.176 27.002 27.490 1.00 51.75 C ATOM 1272 CG ARG A 166 34.946 28.482 27.218 1.00 57.18 C ATOM 1273 CD ARG A 166 35.276 28.817 25.759 1.00 62.36 C ATOM 1274 NE ARG A 166 34.969 30.206 25.408 1.00 66.58 N ATOM 1275 CZ ARG A 166 35.620 31.268 25.882 1.00 67.43 C ATOM 1276 NH1 ARG A 166 36.630 31.110 26.732 1.00 66.05 N ATOM 1277 NH2 ARG A 166 35.253 32.491 25.513 1.00 67.07 N ATOM 1278 N ASP A 167 32.049 26.593 28.243 1.00 46.07 N ATOM 1279 CA ASP A 167 30.685 27.110 28.319 1.00 45.06 C ATOM 1280 C ASP A 167 29.792 25.872 28.350 1.00 42.37 C ATOM 1281 O ASP A 167 29.050 25.610 27.407 1.00 43.51 O ATOM 1282 CB ASP A 167 30.349 27.944 27.074 1.00 48.79 C ATOM 1283 CG ASP A 167 31.124 29.248 27.011 1.00 54.18 C ATOM 1284 OD1 ASP A 167 30.910 30.106 27.895 1.00 56.62 O ATOM 1285 OD2 ASP A 167 31.946 29.417 26.082 1.00 55.65 O ATOM 1286 N PRO A 168 29.856 25.096 29.442 1.00 39.52 N ATOM 1287 CA PRO A 168 29.098 23.862 29.670 1.00 37.72 C ATOM 1288 C PRO A 168 27.584 23.944 29.563 1.00 37.47 C ATOM 1289 O PRO A 168 26.903 22.917 29.536 1.00 36.03 O ATOM 1290 CB PRO A 168 29.539 23.453 31.062 1.00 37.69 C ATOM 1291 CG PRO A 168 29.763 24.765 31.724 1.00 37.62 C ATOM 1292 CD PRO A 168 30.542 25.505 30.677 1.00 38.85 C ATOM 1293 N TYR A 169 27.056 25.160 29.494 1.00 37.62 N ATOM 1294 CA TYR A 169 25.614 25.345 29.412 1.00 37.00 C ATOM 1295 C TYR A 169 25.094 25.746 28.036 1.00 36.98 C ATOM 1296 O TYR A 169 23.897 25.975 27.858 1.00 37.18 O ATOM 1297 CB TYR A 169 25.190 26.336 30.496 1.00 34.19 C ATOM 1298 CG TYR A 169 25.609 25.826 31.856 1.00 34.53 C ATOM 1299 CD1 TYR A 169 25.178 24.577 32.302 1.00 32.17 C ATOM 1300 CD2 TYR A 169 26.533 26.525 32.641 1.00 32.21 C ATOM 1301 CE1 TYR A 169 25.660 24.027 33.474 1.00 29.98 C ATOM 1302 CE2 TYR A 169 27.018 25.982 33.822 1.00 30.03 C ATOM 1303 CZ TYR A 169 26.582 24.729 34.230 1.00 32.02 C ATOM 1304 OH TYR A 169 27.084 24.151 35.378 1.00 30.21 O ATOM 1305 N LEU A 170 26.005 25.817 27.068 1.00 36.47 N ATOM 1306 CA LEU A 170 25.656 26.149 25.694 1.00 37.51 C ATOM 1307 C LEU A 170 25.925 24.903 24.860 1.00 37.28 C ATOM 1308 O LEU A 170 27.051 24.639 24.454 1.00 38.78 O ATOM 1309 CB LEU A 170 26.498 27.320 25.180 1.00 37.64 C ATOM 1310 CG LEU A 170 26.301 28.673 25.867 1.00 39.51 C ATOM 1311 CD1 LEU A 170 27.204 29.710 25.202 1.00 39.46 C ATOM 1312 CD2 LEU A 170 24.835 29.097 25.778 1.00 38.49 C ATOM 1313 N TRP A 171 24.874 24.139 24.615 1.00 35.54 N ATOM 1314 CA TRP A 171 24.987 22.906 23.866 1.00 34.40 C ATOM 1315 C TRP A 171 24.604 23.089 22.416 1.00 35.74 C ATOM 1316 O TRP A 171 23.951 24.062 22.046 1.00 37.22 O ATOM 1317 CB TRP A 171 24.077 21.839 24.489 1.00 32.13 C ATOM 1318 CG TRP A 171 24.524 21.332 25.846 1.00 29.75 C ATOM 1319 CD1 TRP A 171 25.487 21.872 26.659 1.00 27.15 C ATOM 1320 CD2 TRP A 171 24.020 20.183 26.530 1.00 26.04 C ATOM 1321 NE1 TRP A 171 25.613 21.121 27.803 1.00 25.53 N ATOM 1322 CE2 TRP A 171 24.724 20.081 27.750 1.00 25.57 C ATOM 1323 CE3 TRP A 171 23.043 19.227 26.229 1.00 25.82 C ATOM 1324 CZ2 TRP A 171 24.482 19.062 28.668 1.00 24.53 C ATOM 1325 CZ3 TRP A 171 22.804 18.214 27.138 1.00 27.49 C ATOM 1326 CH2 TRP A 171 23.522 18.139 28.347 1.00 26.03 C ATOM 1327 N SER A 172 25.026 22.131 21.600 1.00 35.34 N ATOM 1328 CA SER A 172 24.714 22.115 20.182 1.00 32.85 C ATOM 1329 C SER A 172 23.250 21.704 20.057 1.00 32.82 C ATOM 1330 O SER A 172 22.555 21.504 21.052 1.00 31.10 O ATOM 1331 CB SER A 172 25.545 21.041 19.491 1.00 33.39 C ATOM 1332 OG SER A 172 25.057 19.749 19.855 1.00 29.71 O ATOM 1333 N ALA A 173 22.787 21.574 18.822 1.00 33.17 N ATOM 1334 CA ALA A 173 21.433 21.105 18.585 1.00 33.25 C ATOM 1335 C ALA A 173 21.585 19.585 18.708 1.00 33.08 C ATOM 1336 O ALA A 173 22.698 19.057 18.603 1.00 33.09 O ATOM 1337 CB ALA A 173 20.976 21.475 17.185 1.00 32.36 C ATOM 1338 N PRO A 174 20.481 18.865 18.941 1.00 32.46 N ATOM 1339 CA PRO A 174 20.548 17.408 19.074 1.00 31.07 C ATOM 1340 C PRO A 174 20.871 16.729 17.759 1.00 31.03 C ATOM 1341 O PRO A 174 20.418 17.165 16.717 1.00 33.46 O ATOM 1342 CB PRO A 174 19.154 17.052 19.576 1.00 33.36 C ATOM 1343 CG PRO A 174 18.296 18.097 18.910 1.00 31.14 C ATOM 1344 CD PRO A 174 19.099 19.353 19.117 1.00 30.60 C ATOM 1345 N SER A 175 21.657 15.662 17.802 1.00 31.24 N ATOM 1346 CA SER A 175 22.006 14.943 16.579 1.00 33.10 C ATOM 1347 C SER A 175 20.768 14.236 16.014 1.00 32.35 C ATOM 1348 O SER A 175 19.721 14.196 16.658 1.00 30.56 O ATOM 1349 CB SER A 175 23.077 13.888 16.876 1.00 32.61 C ATOM 1350 OG SER A 175 22.513 12.818 17.619 1.00 32.49 O ATOM 1351 N ASP A 175 20.890 13.677 14.814 1.00 32.66 N ATOM 1352 CA ASP A 176 19.768 12.940 14.233 1.00 34.79 C ATOM 1353 C ASP A 176 19.631 11.673 15.069 1.00 34.58 C ATOM 1354 O ASP A 176 20.619 11.135 15.564 1.00 35.45 O ATOM 1355 CB ASP A 176 20.025 12.590 12.761 1.00 35.48 C ATOM 1356 CG ASP A 176 20.135 13.821 11.876 1.00 34.91 C ATOM 1357 OD1 ASP A 176 19.310 14.751 12.037 1.00 34.44 O ATOM 1358 OD2 ASP A 176 21.043 13.850 11.018 1.00 35.38 O ATOM 1359 N PRO A 177 18.405 11.165 15.223 1.00 35.14 N ATOM 1360 CA PRO A 177 18.152  9.961 16.022 1.00 34.29 C ATOM 1361 C PRO A 177 18.722  8.628 15.530 1.00 34.03 C ATOM 1362 O PRO A 177 18.828  8.374 14.330 1.00 33.49 O ATOM 1363 CB PRO A 177 16.634  9.931 16.092 1.00 34.76 C ATOM 1364 CG PRO A 177 16.268 10.382 14.718 1.00 30.92 C ATOM 1365 CD PRO A 177 17.185 11.581 14.512 1.00 33.15 C ATOM 1366 N LEU A 178 19.081  7.779 16.485 1.00 32.99 N ATOM 1367 CA LEU A 178 19.593  6.455 16.187 1.00 33.07 C ATOM 1368 C LEU A 178 18.756  5.479 17.008 1.00 34.66 C ATOM 1369 O LEU A 178 18.671  5.601 18.226 1.00 35.42 O ATOM 1370 CB LEU A 178 21.075  6.361 16.549 1.00 32.82 C ATOM 1371 CG LEU A 178 21.780  5.010 16.370 1.00 33.57 C ATOM 1372 CD1 LEU A 178 23.276  5.239 16.127 1.00 32.26 C ATOM 1373 CD2 LEU A 178 21.538  4.129 17.611 1.00 30.92 C ATOM 1374 N GLU A 179 18.118  4.531 16.329 1.00 37.07 N ATOM 1375 CA GLU A 179 17.268  3.545 16.977 1.00 39.80 C ATOM 1376 C GLU A 179 18.028  2.253 17.216 1.00 42.53 C ATOM 1377 O GLU A 179 18.295  1.491 16.280 1.00 42.25 O ATOM 1378 CB GLU A 179 16.051  3.255 16.107 1.00 42.34 C ATOM 1379 CG GLU A 179 14.990  2.377 16.759 1.00 47.39 C ATOM 1380 CD GLU A 179 14.272  3.088 17.886 1.00 51.80 C ATOM 1381 OE1 GLU A 179 14.163  4.332 17.807 1.00 53.79 O ATOM 1382 OE2 GLU A 179 13.805  2.414 18.837 1.00 53.63 O ATOM 1383 N LEU A 180 18.370  2.008 18.476 1.00 44.87 N ATOM 1384 CA LEU A 180 19.095  0.808 18.860 1.00 47.29 C ATOM 1385 C LEU A 180 18.134 −0.326 19.216 1.00 51.37 C ATOM 1386 O LEU A 180 17.260 −0.174 20.075 1.00 52.32 O ATOM 1387 CB LEU A 180 19.993  1.103 20.060 1.00 44.12 C ATOM 1388 CG LEU A 180 20.766 −0.097 20.608 1.00 44.50 C ATOM 1389 CD1 LEU A 180 21.868 −0.470 19.633 1.00 42.93 C ATOM 1390 CD2 LEU A 180 21.355  0.239 21.977 1.00 45.76 C ATOM 1391 N VAL A 181 18.289 −1.459 18.543 1.00 54.80 N ATOM 1392 CA VAL A 181 17.454 −2.619 18.821 1.00 59.13 C ATOM 1393 C VAL A 181 18.371 −3.718 19.339 1.00 61.57 C ATOM 1394 O VAL A 181 19.012 −4.424 18.559 1.00 62.08 O ATOM 1395 CB VAL A 181 16.719 −3.114 17.550 1.00 60.05 C ATOM 1396 CG1 VAL A 181 16.053 −4.457 17.819 1.00 60.71 C ATOM 1397 CG2 VAL A 181 15.674 −2.098 17.127 1.00 58.81 C ATOM 1398 N VAL A 182 18.444 −3.848 20.660 1.00 65.09 N ATOM 1399 CA VAL A 182 19.298 −4.857 21.275 1.00 68.86 C ATOM 1400 C VAL A 182 18.786 −6.273 21.001 1.00 70.66 C ATOM 1401 O VAL A 182 17.582 −6.537 21.038 1.00 70.91 O ATOM 1402 CB VAL A 182 19.413 −4.635 22.800 1.00 69.22 C ATOM 1403 CG1 VAL A 182 18.081 −4.884 23.464 1.00 70.10 C ATOM 1404 CG2 VAL A 182 20.482 −5.548 23.381 1.00 70.78 C ATOM 1405 N THR A1 183 19.718 −7.180 20.725 1.00 72.69 N ATOM 1406 CA THR A1 183 19.386 −8.566 20.422 1.00 74.52 C ATOM 1407 C THR A 183 20.363 −9.522 21.102 1.00 75.85 C ATOM 1408 O THR A 183 21.253 −10.049  20.396 1.00 77.27 O ATOM 1409 CB THR A 183 19.432 −8.809 18.902 1.00 74.78 C ATOM 1410 OG1 THR A 183 18.594 −7.851 18.241 1.00 74.27 O ATOM 1411 CG2 THR A 183 18.961 −10.216  18.572 1.00 75.05 C ATOM 1412 OXT THR A 183 20.238 −9.723 22.331 1.00 76.42 O TER 1413 THR A 183 ATOM 1414 N GLY B 0 −0.916 −8.800 −41.627 1.00 76.11 N ATOM 1415 CA GLY B 0 −2.379 −8.812 −41.314 1.00 75.51 C ATOM 1416 C GLY B 0 −2.653 −8.476 −39.863 1.00 74.69 C ATOM 1417 O GLY B 0 −3.454 −7.597 −39.566 1.00 74.32 O ATOM 1418 N GLN B 1 −1.981 −9.178 −38.958 1.00 74.58 N ATOM 1419 CA GLN B 1 −2.147 −8.962 −37.525 1.00 73.94 C ATOM 1420 C GLN B 1 −0.879 −8.352 −36.940 1.00 73.10 C ATOM 1421 O GLN B 1 −0.565 −8.566 −35.761 1.00 72.99 O ATOM 1422 CB GLN B 1 −2.439 −10.292  −36.819 1.00 75.96 C ATOM 1423 CG GLN B 1 −3.915 −10.592  −36.563 1.00 79.43 C ATOM 1424 CD GLN B 1 −4.777 −10.533  −37.814 1.00 81.04 C ATOM 1425 OE1 GLN B 1 −5.015 −9.461 −38.371 1.00 81.58 O ATOM 1426 NE2 GLN B 1 −5.251 −11.694  −38.260 1.00 82.82 N ATOM 1427 N SER B 2 −0.155 −7.597 −37.768 1.00 70.93 N ATOM 1428 CA SER B 2 1.090 −6.955 −37.346 1.00 67.32 C ATOM 1429 C SER B 2 0.770 −5.841 −36.348 1.00 64.63 C ATOM 1430 O SER B 2 0.577 −4.677 −36.718 1.00 62.84 O ATOM 1431 CB SER B 2 1.825 −6.396 −38.566 1.00 67.65 C ATOM 1432 OG SER B 2 3.224 −6.354 −38.342 1.00 68.54 O ATOM 1433 N GLY B 3 0.713 −6.222 −35.075 1.00 61.66 N ATOM 1434 CA GLY B 3 0.380 −5.286 −34.018 1.00 57.33 C ATOM 1435 C GLY B 3 1.466 −4.308 −33.624 1.00 53.83 C ATOM 1436 O GLY B 3 2.539 −4.281 −34.230 1.00 54.15 O ATOM 1437 N PRO B 4 1.207 −3.485 −32.595 1.00 50.46 N ATOM 1438 CA PRO B 4 2.167 −2.492 −32.113 1.00 49.03 C ATOM 1439 C PRO B 4 3.507 −3.069 −31.673 1.00 47.42 C ATOM 1440 O PRO B 4 3.577 −4.099 −30.994 1.00 46.75 O ATOM 1441 CB PRO B 4 1.415 −1.807 −30.967 1.00 48.16 C ATOM 1442 CG PRO B 4 0.471 −2.867 −30.499 1.00 48.05 C ATOM 1443 CD PRO B 4 −0.022 −3.453 −31.784 1.00 48.13 C ATOM 1444 N LEU B 5 4.566 −2.387 −32.088 1.00 44.51 N ATOM 1445 CA LEU B 5 5.916 −2.772 −31.754 1.00 42.00 C ATOM 1446 C LEU B 5 6.114 −2.771 −30.241 1.00 41.52 C ATOM 1447 O LEU B 5 5.443 −2.035 −29.511 1.00 38.34 O ATOM 1448 CB LEU B 5 6.896 −1.805 −32.416 1.00 42.25 C ATOM 1449 CG LEU B 5 6.739 −1.786 −33.934 1.00 43.15 C ATOM 1450 CD1 LEU B 5 7.789 −0.881 −34.543 1.00 44.53 C ATOM 1451 CD2 LEU B 5 6.869 −3.202 −34.482 1.00 44.08 C ATOM 1452 N PRO B 6 7.043 −3.607 −29.752 1.00 41.71 N ATOM 1453 CA PRO B 6 7.337 −3.709 −28.315 1.00 41.67 C ATOM 1454 C PRO B 6 7.703 −2.359 −27.684 1.00 42.24 C ATOM 1455 O PRO B 6 8.496 −1.600 −28.233 1.00 41.49 O ATOM 1456 CB PRO B 6 8.487 −4.722 −28.265 1.00 40.38 C ATOM 1457 CG PRO B 6 9.126 −4.603 −29.641 1.00 41.88 C ATOM 1458 CD PRO B 6 7.938 −4.473 −30.546 1.00 38.69 C ATOM 1459 N LYS B 7 7.120 −2.073 −26.525 1.00 42.93 N ATOM 1460 CA LYS B 7 7.357 −0.814 −25.831 1.00 45.34 C ATOM 1461 C LYS B 7 8.825 −0.523 −25.511 1.00 44.35 C ATOM 1462 O LYS B 7 9.590 −1.423 −25.175 1.00 45.90 O ATOM 1463 CB LYS B 7 6.560 −0.784 −24.522 1.00 46.93 C ATOM 1464 CG LYS B 7 7.111 −1.718 −23.456 1.00 49.09 C ATOM 1465 CD LYS B 7 6.247 −1.737 −22.206 1.00 50.98 C ATOM 1466 CE LYS B 7 6.802 −2.729 −21.187 1.00 53.32 C ATOM 1467 NZ LYS B 7 6.018 −2.754 −19.922 1.00 54.10 N ATOM 1468 N PRO B 8 9.235  0.747 −25.624 1.00 42.33 N ATOM 1469 CA PRO B 8 10.619  1.109 −25.322 1.00 41.52 C ATOM 1470 C PRO B 8 10.749  1.295 −23.819 1.00 40.88 C ATOM 1471 O PRO B 8 9.786  1.114 −23.067 1.00 40.96 O ATOM 1472 CB PRO B 8 10.794  2.432 −26.055 1.00 40.26 C ATOM 1473 CG PRO B 8 9.453  3.066 −25.868 1.00 41.18 C ATOM 1474 CD PRO B 8 8.516  1.898 −26.197 1.00 43.68 C ATOM 1475 N SER B 9 11.946  1.657 −23.386 1.00 38.78 N ATOM 1476 CA SER B 9 12.188  1.898 −21.982 1.00 37.76 C ATOM 1477 C SER B 9 12.270  3.408 −21.799 1.00 35.98 C ATOM 1478 O SER B 9 12.630  4.141 −22.723 1.00 35.63 O ATOM 1479 CB SER B 9 13.506  1.252 −21.554 1.00 37.75 C ATOM 1480 OG SER B 9 14.577  1.783 −22.310 1.00 42.67 O ATOM 1481 N LEU B 10 11.915  3.866 −20.610 1.00 35.05 N ATOM 1482 CA LEU B 10 11.970  5.278 −20.282 1.00 35.79 C ATOM 1483 C LEU B 10 12.429  5.376 −18.841 1.00 37.18 C ATOM 1484 O LEU B 10 11.688  5.040 −17.929 1.00 37.97 O ATOM 1485 CB LEU B 10 10.594  5.921 −20.427 1.00 32.79 C ATOM 1486 CG LEU B 10 10.472  7.377 −19.970 1.00 33.11 C ATOM 1487 CD1 LEU B 10 11.563  8.255 −20.627 1.00 29.06 C ATOM 1488 CD2 LEU B 10 9.070  7.883 −20.318 1.00 31.07 C ATOM 1489 N GLN B 11 13.661  5.814 −18.632 1.00 39.79 N ATOM 1490 CA GLN B 11 14.159  5.929 −17.277 1.00 41.73 C ATOM 1491 C GLN B 11 14.713  7.310 −17.001 1.00 40.82 C ATOM 1492 O GLN B 11 14.964  8.090 −17.921 1.00 40.87 O ATOM 1493 CB GLN B 11 15.221  4.862 −17.014 1.00 45.84 C ATOM 1494 CG GLN B 11 16.382  4.871 −17.985 1.00 53.62 C ATOM 1495 CD GLN B 11 17.255  3.628 −17.846 1.00 58.56 C ATOM 1496 OE1 GLN B 11 16.812  2.505 −18.133 1.00 59.65 O ATOM 1497 NE2 GLN B 11 18.501  3.820 −17.401 1.00 57.80 N ATOM 1498 N ALA B 12 14.888  7.608 −15.721 1.00 39.93 N ATOM 1499 CA ALA B 12 15.406  8.892 −15.284 1.00 38.99 C ATOM 1500 C ALA B 12 16.749  8.705 −14.576 1.00 39.34 C ATOM 1501 O ALA B 12 16.870  7.912 −13.637 1.00 39.09 O ATOM 1502 CB ALA B 12 14.395  9.569 −14.351 1.00 34.74 C ATOM 1503 N LEU B 13 17.756  9.437 −15.034 1.00 38.76 N ATOM 1504 CA LEU B 13 19.083  9.348 −14.447 1.00 39.97 C ATOM 1505 C LEU B 13 19.455 10.673 −13.801 1.00 39.10 C ATOM 1506 O LEU B 13 19.158 11.738 −14.337 1.00 39.92 O ATOM 1507 CB LEU B 13 20.109  8.991 −15.523 1.00 41.41 C ATOM 1508 CG LEU B 13 19.758  7.775 −16.384 1.00 44.56 C ATOM 1509 CD1 LEU B 13 20.621  7.750 −17.635 1.00 43.42 C ATOM 1510 CD2 LEU B 13 19.926  6.507 −15.563 1.00 46.07 C ATOM 1511 N PRO B 14 20.108 10.620 −12.631 1.00 37.97 N ATOM 1512 CA PRO B 14 20.462  9.359 −11.971 1.00 38.97 C ATOM 1513 C PRO B 14 19.292  8.732 −11.198 1.00 40.43 C ATOM 1514 O PRO B 14 19.406  7.598 −10.723 1.00 41.67 O ATOM 1515 CB PRO B 14 21.608  9.768 −11.049 1.00 35.49 C ATOM 1516 CG PRO B 14 21.192 11.122 −10.630 1.00 35.62 C ATOM 1517 CD PRO B 14 20.702 11.764 −11.920 1.00 35.91 C ATOM 1518 N SER B 15 18.175  9.458 −11.082 1.00 39.35 N ATOM 1519 CA SER B 15 17.015  8.947 −10.350 1.00 38.53 C ATOM 1520 C SER B 15 15.675  9.619 −10.659 1.00 38.34 C ATOM 1521 O SER B 15 15.630 10.711 −11.218 1.00 37.17 O ATOM 1522 CB SER B 15 17.272  9.044 −8.846 1.00 36.82 C ATOM 1523 OG SER B 15 16.127  8.649 −8.107 1.00 37.33 O ATOM 1524 N SER B 16 14.590  8.946 −10.267 1.00 39.07 N ATOM 1525 CA SER B 16 13.223  9.433 −10.453 1.00 38.15 C ATOM 1526 C SER B 16 12.858 10.421 −9.364 1.00 38.46 C ATOM 1527 O SER B 16 12.021 11.296 −9.577 1.00 39.46 O ATOM 1528 CB SER B 16 12.229  8.284 −10.402 1.00 39.10 C ATOM 1529 OG SER B 16 12.401  7.417 −11.500 1.00 46.01 O ATOM 1530 N LEU B 17 13.455 10.250 −8.186 1.00 38.48 N ATOM 1531 CA LEU B 17 13.222 11.151 −7.059 1.00 38.73 C ATOM 1532 C LEU B 17 14.220 12.279 −7.256 1.00 38.04 C ATOM 1533 O LEU B 17 15.408 12.109 −6.993 1.00 38.28 O ATOM 1534 CB LEU B 17 13.498 10.442 −5.728 1.00 40.34 C ATOM 1535 CG LEU B 17 12.443  9.501 −5.143 1.00 43.65 C ATOM 1536 CD1 LEU B 17 11.221 10.310 −4.780 1.00 45.10 C ATOM 1537 CD2 LEU B 17 12.078  8.405 −6.137 1.00 44.83 C ATOM 1538 N VAL B 18 13.734 13.429 −7.713 1.00 37.92 N ATOM 1539 CA VAL B 18 14.598 14.570 −8.001 1.00 36.34 C ATOM 1540 C VAL B 18 14.317 15.800 −7.161 1.00 37.48 C ATOM 1541 O VAL B 18 13.259 16.416 −7.286 1.00 36.65 O ATOM 1542 CB VAL B 18 14.465 15.005 −9.486 1.00 36.96 C ATOM 1543 CG1 VAL B 18 15.699 15.808 −9.910 1.00 32.75 C ATOM 1544 CG2 VAL B 18 14.258 13.783 −10.386 1.00 35.47 C ATOM 1545 N PRO B 19 15.269 16.185 −6.294 1.00 39.40 N ATOM 1546 CA PRO B 19 15.041 17.375 −5.468 1.00 38.70 C ATOM 1547 C PRO B 19 15.056 18.604 −6.352 1.00 38.08 C ATOM 1548 O PRO B 19 15.753 18.626 −7.364 1.00 36.89 O ATOM 1549 CB PRO B 19 16.203 17.343 −4.473 1.00 38.32 C ATOM 1550 CG PRO B 19 17.262 16.578 −5.189 1.00 40.30 C ATOM 1551 CD PRO B 19 16.504 15.488 −5.891 1.00 39.74 C ATOM 1552 N LEU B 20 14.270 19.610 −5.984 1.00 37.74 N ATOM 1553 CA LEU B 20 14.210 20.840 −6.765 1.00 39.73 C ATOM 1554 C LEU B 20 15.604 21.369 −7.077 1.00 41.81 C ATOM 1555 O LEU B 20 16.548 21.184 −6.303 1.00 43.28 O ATOM 1556 CB LEU B 20 13.420 21.921 −6.020 1.00 37.07 C ATOM 1557 CG LEU B 20 11.990 21.551 −5.633 1.00 38.86 C ATOM 1558 CD1 LEU B 20 11.330 22.732 −4.937 1.00 38.75 C ATOM 1559 CD2 LEU B 20 11.203 21.153 −6.876 1.00 36.95 C ATOM 1560 N GLU B 21 15.720 22.026 −8.225 1.00 42.17 N ATOM 1561 CA GLU B 21 16.972 22.607 −8.671 1.00 42.62 C ATOM 1562 C GLU B 21 18.072 21.593 −8.983 1.00 42.20 C ATOM 1563 O GLU B 21 19.183 21.973 −9.346 1.00 42.95 O ATOM 1564 CB GLU B 21 17.460 23.629 −7.643 1.00 41.87 C ATOM 1565 CG GLU B 21 16.467 24.759 −7.405 1.00 44.41 C ATOM 1566 CD GLU B 21 15.918 25.345 −8.702 1.00 46.18 C ATOM 1567 OE1 GLU B 21 16.726 25.738 −9.566 1.00 47.48 O ATOM 1568 OE2 GLU B 21 14.678 25.413 −8.860 1.00 48.55 O ATOM 1569 N LYS B 22 17.775 20.308 −8.841 1.00 40.59 N ATOM 1570 CA LYS B 22 18.769 19.290 −9.161 1.00 41.63 C ATOM 1571 C LYS B 22 18.521 18.764 −10.579 1.00 40.37 C ATOM 1572 O LYS B 22 17.422 18.899 −11.121 1.00 39.93 O ATOM 1573 CB LYS B 22 18.717 18.150 −8.148 1.00 44.86 C ATOM 1574 CG LYS B 22 19.453 18.441 −6.845 1.00 48.49 C ATOM 1575 CD LYS B 22 20.946 18.282 −7.024 1.00 51.44 C ATOM 1576 CE LYS B 22 21.672 18.303 −5.688 1.00 54.38 C ATOM 1577 NZ LYS B 22 23.073 17.772 −5.804 1.00 55.73 N ATOM 1578 N PRO B 23 19.546 18.164 −11.201 1.00 39.83 N ATOM 1579 CA PRO B 23 19.433 17.628 −12.562 1.00 38.04 C ATOM 1580 C PRO B 23 18.791 16.255 −12.718 1.00 36.68 C ATOM 1581 O PRO B 23 18.840 15.420 −11.815 1.00 35.68 O ATOM 1582 CB PRO B 23 20.878 17.621 −13.032 1.00 35.55 C ATOM 1583 CG PRO B 23 21.591 17.212 −11.782 1.00 37.07 C ATOM 1584 CD PRO B 23 20.944 18.089 −10.731 1.00 38.52 C ATOM 1585 N VAL B 24 18.178 16.038 −13.878 1.00 35.26 N ATOM 1586 CA VAL B 24 17.581 14.744 −14.198 1.00 34.16 C ATOM 1587 C VAL B 24 17.541 14.553 −15.697 1.00 32.06 C ATOM 1588 O VAL B 24 17.198 15.462 −16.442 1.00 32.80 O ATOM 1589 CB VAL B 24 16.139 14.573 −13.642 1.00 35.06 C ATOM 1590 CG1 VAL B 24 15.190 15.578 −14.278 1.00 32.12 C ATOM 1591 CG2 VAL B 24 15.666 13.141 −13.910 1.00 31.10 C ATOM 1592 N THR B 25 17.904 13.365 −16.142 1.00 32.41 N ATOM 1593 CA THR B 25 17.901 13.074 −17.566 1.00 34.56 C ATOM 1594 C THR B 25 16.896 11.964 −17.847 1.00 35.02 C ATOM 1595 O THR B 25 16.971 10.890 −17.254 1.00 35.11 O ATOM 1596 CB THR B 25 19.302 12.621 −18.045 1.00 33.96 C ATOM 1597 OG1 THR B 25 20.249 13.666 −17.802 1.00 37.14 O ATOM 1598 CG2 THR B 25 19.292 12.303 −19.523 1.00 32.40 C ATOM 1599 N LEU B 26 15.942 12.238 −18.730 1.00 35.70 N ATOM 1600 CA LEU B 26 14.948 11.243 −19.100 1.00 37.65 C ATOM 1601 C LEU B 26 15.380 10.651 −20.430 1.00 37.96 C ATOM 1602 O LEU B 26 15.529 11.360 −21.416 1.00 38.81 O ATOM 1603 CB LEU B 26 13.560 11.871 −19.211 1.00 38.89 C ATOM 1604 CG LEU B 26 12.853 12.207 −17.893 1.00 41.77 C ATOM 1605 CD1 LEU B 26 13.627 13.285 −17.157 1.00 43.79 C ATOM 1606 CD2 LEU B 26 11.424 12.694 −18.176 1.00 43.06 C ATOM 1607 N ARG B 27 15.589  9.342 −20.440 1.00 39.90 N ATOM 1608 CA ARG B 27 16.047  8.634 −21.624 1.00 40.88 C ATOM 1609 C ARG B 27 15.072  7.549 −22.102 1.00 41.05 C ATOM 1610 O ARG B 27 14.734  6.607 −21.365 1.00 39.39 O ATOM 1611 CB ARG B 27 17.419  8.028 −21.309 1.00 45.70 C ATOM 1612 CG ARG B 27 18.056  7.170 −22.390 1.00 53.67 C ATOM 1613 CD ARG B 27 19.434  6.685 −21.917 1.00 59.18 C ATOM 1614 NE ARG B 27 19.971  5.615 −22.756 1.00 66.42 N ATOM 1615 CZ ARG B 27 21.127  4.990 −22.533 1.00 68.44 C ATOM 1616 NH1 ARG B 27 21.878  5.330 −21.491 1.00 68.78 N ATOM 1617 NH2 ARG B 27 21.530  4.021 −23.350 1.00 67.63 N ATOM 1618 N CYS B 28 14.618  7.702 −23.342 1.00 39.46 N ATOM 1619 CA CYS B 28 13.714  6.746 −23.964 1.00 40.06 C ATOM 1620 C CYS B 28 14.602  5.838 −24.797 1.00 41.47 C ATOM 1621 O CYS B 28 15.423  6.314 −25.578 1.00 41.30 O ATOM 1622 CB CYS B 28 12.719  7.468 −24.870 1.00 39.09 C ATOM 1623 SG CYS B 28 11.419  6.413 −25.592 1.00 40.76 S ATOM 1624 N GLN B 29 14.458  4.530 −24.630 1.00 45.47 N ATOM 1625 CA GLN B 29 15.290  3.605 −25.392 1.00 47.54 C ATOM 1626 C GLN B 29 14.519  2.465 −26.040 1.00 47.10 C ATOM 1627 O GLN B 29 13.830  1.700 −25.371 1.00 46.86 O ATOM 1628 CB GLN B 29 16.389  3.021 −24.502 1.00 50.07 C ATOM 1629 CG GLN B 29 17.316  2.063 −25.241 1.00 54.22 C ATOM 1630 CD GLN B 29 18.168  2.759 −26.291 1.00 57.28 C ATOM 1631 OE1 GLN B 29 19.080  3.523 −25.962 1.00 60.11 O ATOM 1632 NE2 GLN B 29 17.871  2.504 −27.561 1.00 57.17 N ATOM 1633 N GLY B 30 14.644  2.365 −27.356 1.00 48.10 N ATOM 1634 CA GLY B 30 13.984  1.302 −28.087 1.00 48.88 C ATOM 1635 C GLY B 30 15.040  0.407 −28.709 1.00 48.92 C ATOM 1636 O GLY B 30 16.233  0.674 −28.572 1.00 49.72 O ATOM 1637 N PRO B 31 14.643 −0.671 −29.390 1.00 49.44 N ATOM 1638 CA PRO B 31 15.645 −1.547 −30.002 1.00 50.19 C ATOM 1639 C PRO B 31 16.267 −0.838 −31.192 1.00 51.51 C ATOM 1640 O PRO B 31 15.819  0.242 −31.576 1.00 50.81 O ATOM 1641 CB PRO B 31 14.824 −2.760 −30.419 1.00 49.60 C ATOM 1642 CG PRO B 31 13.509 −2.133 −30.796 1.00 50.27 C ATOM 1643 CD PRO B 31 13.278 −1.154 −29.665 1.00 49.39 C ATOM 1644 N PRO B 32 17.316 −1.424 −31.790 1.00 53.98 N ATOM 1645 CA PRO B 32 17.918 −0.748 −32.945 1.00 53.80 C ATOM 1646 C PRO B 32 16.905 −0.684 −34.084 1.00 52.92 C ATOM 1647 O PRO B 32 16.124 −1.617 −34.276 1.00 53.02 O ATOM 1648 CB PRO B 32 19.103 −1.645 −33.283 1.00 54.89 C ATOM 1649 CG PRO B 32 18.580 −3.016 −32.917 1.00 53.63 C ATOM 1650 CD PRO B 32 17.929 −2.750 −31.576 1.00 52.83 C ATOM 1651 N GLY B 33 16.904  0.420 −34.824 1.00 53.07 N ATOM 1652 CA GLY B 33 15.982  0.542 −35.941 1.00 52.09 C ATOM 1653 C GLY B 33 14.884  1.571 −35.766 1.00 51.47 C ATOM 1654 O GLY B 33 13.942  1.638 −36.565 1.00 50.58 O ATOM 1655 N VAL B 34 14.991  2.378 −34.719 1.00 50.07 N ATOM 1656 CA VAL B 34 13.986  3.398 −34.479 1.00 49.03 C ATOM 1657 C VAL B 34 14.186  4.529 −35.486 1.00 48.95 C ATOM 1658 O VAL B 34 15.314  4.948 −35.751 1.00 49.29 O ATOM 1659 CB VAL B 34 14.096  3.937 −33.041 1.00 49.10 C ATOM 1660 CG1 VAL 34 13.023  4.996 −32.786 1.00 49.37 C ATOM 1661 CG2 34 13.953  2.783 −32.060 1.00 46.32 C ATOM 1662 N ASP B 35 13.092  5.001 −36.071 1.00 48.43 N ATOM 1663 CA ASP B 35 13.171  6.080 −37.046 1.00 46.78 C ATOM 1664 C ASP B 35 12.760  7.363 −36.379 1.00 45.10 C ATOM 1665 O ASP B 35 13.186  8.450 −36.762 1.00 46.24 O ATOM 1666 CB ASP B 35 12.226  5.835 −38.223 1.00 46.93 C ATOM 1667 CG ASP B 35 12.606  4.627 −39.032 1.00 46.98 C ATOM 1668 OD1 ASP B 35 13.821  4.383 −39.186 1.00 47.82 O ATOM 1669 OD2 ASP B 35 11.691  3.936 −39.530 1.00 48.35 O ATOM 1670 N LEU B 36 11.916  7.227 −35.371 1.00 44.30 N ATOM 1671 CA LEU B 36 11.411  8.384 −34.669 1.00 44.07 C ATOM 1672 C LEU B 36 11.064  8.056 −33.231 1.00 43.46 C ATOM 1673 O LEU B 36 10.439  7.036 −32.936 1.00 42.25 O ATOM 1674 CB LEU B 36 10.164  8.918 −35.387 1.00 43.64 C ATOM 1675 CG LEU B 36 9.414 10.085 −34.741 1.00 46.63 C ATOM 1676 CD1 LEU B 36 10.282 11.344 −34.770 1.00 45.85 C ATOM 1677 CD2 LEU B 36 8.104 10.321 −35.482 1.00 46.87 C ATOM 1678 N TYR B 37 11.495  8.934 −32.339 1.00 42.00 N ATOM 1679 CA TYR B 37 11.207  8.796 −30.932 1.00 40.65 C ATOM 1680 C TYR B 37 10.218  9.887 −30.594 1.00 41.05 C ATOM 1681 O TYR B 37 10.086 10.867 −31.323 1.00 42.03 O ATOM 1682 CB TYR B 37 12.468  9.000 −30.116 1.00 39.25 C ATOM 1683 CG TYR B 37 13.257  7.744 −29.893 1.00 39.18 C ATOM 1684 CD1 TYR B 37 12.808  6.779 −29.000 1.00 35.91 C ATOM 1685 CD2 TYR B 37 14.474  7.533 −30.544 1.00 36.15 C ATOM 1686 CE1 TYR B 37 13.547  5.638 −28.750 1.00 36.56 C ATOM 1687 CE2 TYR B 37 15.220  6.394 −30.301 1.00 36.95 C ATOM 1688 CZ TYR B 37 14.751  5.451 −29.396 1.00 36.67 C ATOM 1689 OH TYR B 37 15.501  4.337 −29.102 1.00 38.70 O ATOM 1690 N ARG B 38 9.518  9.713 −29.486 1.00 42.64 N ATOM 1691 CA ARG B 38 8.555 10.703 −29.042 1.00 43.15 C ATOM 1692 C ARG B 38 8.390 10.574 −27.540 1.00 42.41 C ATOM 1693 O ARG B 38 7.883  9.575 −27.043 1.00 44.73 O ATOM 1694 CB ARG B 38 7.210 10.510 −29.743 1.00 41.74 C ATOM 1695 CG ARG B 38 6.157 11.497 −29.280 1.00 46.02 C ATOM 1696 CD ARG B 38 4.910 11.418 −30.134 1.00 48.21 C ATOM 1697 NE ARG B 38 5.167 11.842 −31.505 1.00 50.43 N ATOM 1698 CZ ARG B 38 4.268 11.772 −32.479 1.00 52.29 C ATOM 1699 NH1 ARG B 38 3.060 11.294 −32.217 1.00 53.85 N ATOM 1700 NH2 ARG B 38 4.572 12.174 −33.706 1.00 51.92 N ATOM 1701 N LEU B 39 8.847 11.586 −26.819 1.00 42.38 N ATOM 1702 CA LEU B 39 8.751 11.593 −25.371 1.00 40.18 C ATOM 1703 C LEU B 39 7.701 12.645 −25.043 1.00 41.53 C ATOM 1704 O LEU B 39 7.709 13.745 −25.606 1.00 41.57 O ATOM 1705 CB LEU B 39 10.113 11.941 −24.776 1.00 39.30 C ATOM 1706 CG LEU B 39 10.251 12.235 −23.285 1.00 40.62 C ATOM 1707 CD1 LEU B 39 9.611 11.146 −22.461 1.00 43.92 C ATOM 1708 CD2 LEU B 39 11.724 12.344 −22.959 1.00 43.37 C ATOM 1709 N GLU B 40 6.791 12.311 −24.139 1.00 41.64 N ATOM 1710 CA GLU B 40 5.718 13.231 −23.808 1.00 42.24 C ATOM 1711 C GLU B 40 5.378 13.309 −22.329 1.00 40.88 C ATOM 1712 O GLU B 40 5.462 12.319 −21.608 1.00 41.34 O ATOM 1713 CB GLU B 40 4.472 12.819 −24.601 1.00 43.82 C ATOM 1714 CG GLU B 40 3.297 13.770 −24.519 1.00 49.55 C ATOM 1715 CD GLU B 40 2.112 13.281 −25.341 1.00 53.26 C ATOM 1716 OE1 GLU B 40 2.310 12.972 −26.538 1.00 53.51 O ATOM 1717 OE2 GLU B 40 0.986 13.204 −24.792 1.00 54.66 O ATOM 1718 N LYS B 41 4.998 14.503 −21.887 1.00 40.87 N ATOM 1719 CA LYS B 41 4.590 14.728 −20.507 1.00 39.45 C ATOM 1720 C LYS B 41 3.071 14.652 −20.572 1.00 40.15 C ATOM 1721 O LYS B 41 2.431 15.484 −21.197 1.00 42.08 O ATOM 1722 CB LYS B 41 5.038 16.109 −20.023 1.00 37.29 C ATOM 1723 CG LYS B 41 4.900 16.299 −18.527 1.00 36.03 C ATOM 1724 CD LYS B 41 5.546 17.589 −18.060 1.00 37.36 C ATOM 1725 CE LYS B 41 5.556 17.691 −16.538 1.00 36.25 C ATOM 1726 NZ LYS B 41 4.183 17.550 −15.956 1.00 39.49 N ATOM 1727 N LEU B 42 2.504 13.642 −19.931 1.00 41.82 N ATOM 1728 CA LEU B 42 1.065 13.403 −19.945 1.00 42.85 C ATOM 1729 C LEU B 42 0.119 14.536 −19.529 1.00 43.81 C ATOM 1730 O LEU B 42 −1.001 14.612 −20.027 1.00 43.08 O ATOM 1731 CB LEU B 42 0.757 12.156 −19.105 1.00 42.65 C ATOM 1732 CG LEU B 42 1.490 10.869 −19.514 1.00 42.87 C ATOM 1733 CD1 LEU B 42 0.945  9.706 −18.713 1.00 43.12 C ATOM 1734 CD2 LEU B 42 1.314 10.606 −21.000 1.00 41.76 C ATOM 1735 N SER B 43 0.554 15.410 −18.629 1.00 44.11 N ATOM 1736 CA SER B 43 −0.306 16.491 −18.155 1.00 44.55 C ATOM 1737 C SER B 43 −0.537 17.603 −19.165 1.00 46.82 C ATOM 1738 O SER B 43 −1.557 18.296 −19.113 1.00 45.47 O ATOM 1739 CB SER B 43 0.272 17.109 −16.880 1.00 44.17 C ATOM 1740 OG SER B 43 1.483 17.792 −17.150 1.00 45.33 O ATOM 1741 N SER B 44 0.408 17.774 −20.083 1.00 48.47 N ATOM 1742 CA SER B 44 0.306 18.833 −21.074 1.00 49.87 C ATOM 1743 C SER B 44 0.056 18.331 −22.482 1.00 51.00 C ATOM 1744 O SER B 44 −0.318 19.105 −23.357 1.00 51.61 O ATOM 1745 CB SER B 44 1.587 19.667 −21.076 1.00 50.93 C ATOM 1746 OG SER B 44 2.660 18.953 −21.676 1.00 52.12 O ATOM 1747 N SER B 45 0.260 17.040 −22.705 1.00 53.00 N ATOM 1748 CA SER B 45 0.079 16.471 −24.035 1.00 55.24 C ATOM 1749 C SER B 45 1.047 17.181 −24.981 1.00 56.21 C ATOM 1750 O SER B 45 0.763 17.368 −26.165 1.00 58.19 O ATOM 1751 CB SER B 45 −1.367 16.654 −24.520 1.00 55.71 C ATOM 1752 OG SER B 45 −2.285 15.952 −23.698 1.00 55.41 O ATOM 1753 N ARG B 46 2.183 17.598 −24.432 1.00 56.13 N ATOM 1754 CA ARG B 46 3.226 18.263 −25.205 1.00 55.10 C ATOM 1755 C ARG B 46 4.382 17.274 −25.320 1.00 52.12 C ATOM 1756 O ARG B 46 4.956 16.857 −24.316 1.00 50.57 O ATOM 1757 CB ARG B 46 3.688 19.541 −24.496 1.00 57.87 C ATOM 1758 CG ARG B 46 4.932 20.198 −25.108 1.00 61.31 C ATOM 1759 CD ARG B 46 6.137 20.129 −24.151 1.00 64.42 C ATOM 1760 NE ARG B 46 6.681 18.772 −24.008 1.00 63.25 N ATOM 1761 CZ ARG B 46 7.503 18.389 −23.032 1.00 61.20 C ATOM 1762 NH1 ARG B 46 7.880 19.259 −22.095 1.00 57.41 N ATOM 1763 NH2 ARG B 46 7.956 17.140 −23.006 1.00 55.99 N ATOM 1764 N TYR B 47 4.713 16.893 −26.548 1.00 50.61 N ATOM 1765 CA TYR B 47 5.784 15.937 −26.775 1.00 46.46 C ATOM 1766 C TYR B 47 6.921 16.509 −27.612 1.00 44.21 C ATOM 1767 O TYR B 47 6.802 17.582 −28.195 1.00 42.05 O ATOM 1768 CB TYR B 47 5.216 14.696 −27.455 1.00 45.94 C ATOM 1769 CG TYR B 47 4.728 14.952 −28.853 1.00 45.67 C ATOM 1770 CD1 TYR B 47 5.621 15.017 −29.916 1.00 46.57 C ATOM 1771 CD2 TYR B 47 3.376 15.149 −29.116 1.00 47.06 C ATOM 1772 CE1 TYR B 47 5.189 15.271 −31.205 1.00 47.71 C ATOM 1773 CE2 TYR B 47 2.929 15.405 −30.408 1.00 46.90 C ATOM 1774 CZ TYR B 47 3.843 15.465 −31.447 1.00 47.09 C ATOM 1775 OH TYR B 47 3.429 15.731 −32.733 1.00 48.36 O ATOM 1776 N GLN B 48 8.027 15.773 −27.645 1.00 43.37 N ATOM 1777 CA GLN B 48 9.210 16.144 −28.407 1.00 41.64 C ATOM 1778 C GLN B 48 9.567 14.950 −29.271 1.00 41.91 C ATOM 1779 O GLN B 48 9.104 13.837 −29.014 1.00 41.10 O ATOM 1780 CB GLN B 48 10.385 16.457 −27.473 1.00 42.45 C ATOM 1781 CG GLN B 48 10.825 15.293 −26.581 1.00 40.39 C ATOM 1782 CD GLN B 48 12.050 15.633 −25.751 1.00 39.63 C ATOM 1783 OE1 GLN B 48 12.110 16.689 −25.123 1.00 39.88 O ATOM 1784 NE2 GLN B 48 13.032 14.736 −25.740 1.00 37.82 N ATOM 1785 N ASP B 49 10.401 15.177 −30.279 1.00 42.14 N ATOM 1786 CA ASP B 49 10.804 14.106 −31.179 1.00 44.17 C ATOM 1787 C ASP B 49 12.136 13.496 −30.799 1.00 43.42 C ATOM 1788 O ASP B 49 12.644 12.628 −31.508 1.00 44.77 O ATOM 1789 CB ASP B 49 10.885 14.616 −32.621 1.00 47.70 C ATOM 1790 CG ASP B 49 9.552 15.121 −33.135 1.00 51.03 C ATOM 1791 OD1 ASP B 49 8.561 14.357 −33.072 1.00 54.50 O ATOM 1792 OD2 ASP B 49 9.495 16.281 −33.600 1.00 53.31 O ATOM 1793 N GLN B 50 12.696 13.937 −29.679 1.00 42.44 N ATOM 1794 CA GLN B 50 13.988 13.432 −29.234 1.00 42.29 C ATOM 1795 C GLN B 50 13.847 12.397 −28.120 1.00 41.76 C ATOM 1796 O GLN B 50 12.947 12.486 −27.289 1.00 40.40 O ATOM 1797 CB GLN B 50 14.866 14.597 −28.764 1.00 44.59 C ATOM 1798 CG GLN B 50 15.219 15.628 −29.852 1.00 48.68 C ATOM 1799 CD GLN B 50 14.026 16.471 −30.335 1.00 53.36 C ATOM 1800 OE1 GLN B 50 13.284 17.060 −29.535 1.00 52.68 O ATOM 1801 NE2 GLN B 50 13.853 16.543 −31.656 1.00 55.77 N ATOM 1802 N ALA B 51 14.743 11.412 −28.111 1.00 39.65 N ATOM 1803 CA ALA B 51 14.715 10.358 −27.101 1.00 38.16 C ATOM 1804 C ALA B 51 15.130 10.840 −25.708 1.00 38.77 C ATOM 1805 O ALA B 51 14.766 10.227 −24.700 1.00 38.70 O ATOM 1806 CB ALA B 51 15.623  9.205 −27.531 1.00 35.19 C ATOM 1807 N VAL B 52 15.881 11.937 −25.643 1.00 36.88 N ATOM 1808 CA VAL B 52 16.353 12.435 −24.358 1.00 36.41 C ATOM 1809 C VAL B 52 15.849 13.807 −23.933 1.00 36.63 C ATOM 1810 O VAL B 52 15.935 14.764 −24.691 1.00 38.92 O ATOM 1811 CB VAL B 52 17.890 12.492 −24.337 1.00 36.70 C ATOM 1812 CG1 VAL B 52 18.370 13.120 −23.039 1.00 35.28 C ATOM 1813 CG2 VAL B 52 18.460 11.107 −24.503 1.00 34.89 C ATOM 1814 N LEU B 53 15.326 13.899 −22.713 1.00 35.98 N ATOM 1815 CA LEU B 53 14.871 15.175 −22.173 1.00 35.66 C ATOM 1816 C LEU B 53 15.734 15.478 −20.957 1.00 36.25 C ATOM 1817 O LEU B 53 15.617 14.817 −19.924 1.00 36.96 O ATOM 1818 CB LEU B 53 13.391 15.128 −21.760 1.00 33.43 C ATOM 1819 CG LEU B 53 12.897 16.300 −20.887 1.00 34.36 C ATOM 1820 CD1 LEU B 53 13.249 17.643 −21.511 1.00 30.60 C ATOM 1821 CD2 LEU B 53 11.390 16.187 −20.675 1.00 31.30 C ATOM 1822 N PHE B 54 16.613 16.467 −21.083 1.00 36.44 N ATOM 1823 CA PHE B 54 17.483 16.846 −19.975 1.00 34.55 C ATOM 1824 C PHE B 54 16.942 18.052 −19.221 1.00 34.18 C ATOM 1825 O PHE B 54 16.685 19.105 −19.806 1.00 34.13 O ATOM 1826 CB PHE B 54 18.895 17.152 −20.482 1.00 35.31 C ATOM 1827 CG PHE B 54 19.829 17.659 −19.412 1.00 34.98 C ATOM 1828 CD1 PHE B 54 19.986 16.961 −18.217 1.00 36.58 C ATOM 1829 CD2 PHE B 54 20.554   18.829 3 −19.60 1.00 36.37 C ATOM 1830 CE1 PHE B 54 20.855 17.418 −17.219 1.00 36.79 C ATOM 1831 CE2 PHE B 54 21.427 19.302 −18.617 1.00 38.09 C ATOM 1832 CZ PHE B 54 21.579 18.589 −17.416 1.00 38.04 C ATOM 1833 N ILE B 55 16.769 17.880 −17.915 1.00 34.15 N ATOM 1834 CA ILE B 55 16.283 18.932 −17.028 1.00 33.65 C ATOM 1835 C ILE B 55 17.457 19.303 −16.111 1.00 35.39 C ATOM 1836 O ILE B 55 17.740 18.591 −15.146 1.00 36.77 O ATOM 1837 CB ILE B 55 15.105 18.413 −16.168 1.00 32.55 C ATOM 1838 CG1 ILE B 55 13.906 18.086 −17.062 1.00 29.44 C ATOM 1839 CG2 ILE B 55 14.725 19.434 −15.105 1.00 32.67 C ATOM 1840 CD1 ILE B 55 12.743 17.431 −16.305 1.00 27.00 C ATOM 1841 N PRO B 56 18.163 20.411 −16.406 1.00 36.87 N ATOM 1842 CA PRO B 56 19.304 20.833 −15.581 1.00 36.83 C ATOM 1843 C PRO B 56 18.940 21.112 −14.130 1.00 37.90 C ATOM 1844 O PRO B 56 19.655 20.694 −13.215 1.00 39.82 O ATOM 1845 CB PRO B 56 19.815 22.078 −16.298 1.00 36.41 C ATOM 1846 CG PRO B 56 18.568 22.643 −16.920 1.00 38.39 C ATOM 1847 CD PRO B 56 17.886 21.405 −17.462 1.00 38.09 C ATOM 1848 N ALA B 57 17.830 21.817 −13.922 1.00 36.40 N ATOM 1849 CA ALA B 57 17.364 22.137 −12.576 1.00 35.59 C ATOM 1850 C ALA B 57 15.891 21.762 −12.424 1.00 34.76 C ATOM 1851 O ALA B 57 15.016 22.428 −12.976 1.00 33.28 O ATOM 1852 CB ALA B 57 17.559 23.617 −12.299 1.00 34.90 C ATOM 1853 N MET B 58 15.622 20.703 −11.662 1.00 35.79 N ATOM 1854 CA MET B 58 14.247 20.227 −11.454 1.00 36.56 C ATOM 1855 C MET B 58 13.288 21.288 −10.893 1.00 34.88 C ATOM 1856 O MET B 58 13.566 21.928 −9.880 1.00 35.56 O ATOM 1857 CB MET B 58 14.258 18.991 −10.555 1.00 34.64 C ATOM 1858 CG MET B 58 12.889 18.389 −10.280 1.00 37.25 C ATOM 1859 SD MET B 58 11.953 17.858 −11.735 1.00 36.75 S ATOM 1860 CE MET B 58 12.850 16.469 −12.223 1.00 38.27 C ATOM 1861 N LYS B 59 12.164 21.470 −11.580 1.00 34.76 N ATOM 1862 CA LYS B 59 11.148 22.453 −11.193 1.00 32.97 C ATOM 1863 C LYS B 59 9.856 21.722 −10.846 1.00 33.46 C ATOM 1864 O LYS B 59 9.676 20.561 −11.230 1.00 33.85 O ATOM 1865 CB LYS B 59 10.885 23.425 −12.349 1.00 31.89 C ATOM 1866 CG LYS B 59 12.141 24.032 −12.988 1.00 31.89 C ATOM 1867 CD LYS B 59 12.923 24.899 −12.012 1.00 30.77 C ATOM 1868 CE LYS B 59 14.021 25.688 −12.729 1.00 31.56 C ATOM 1869 NZ LYS B 59 14.875 26.493 −11.794 1.00 31.88 N ATOM 1870 N ARG B 60 8.960 22.394 −10.128 1.00 32.63 N ATOM 1871 CA ARG B 60 7.699 21.771 −9.745 1.00 32.73 C ATOM 1872 C ARG B 60 6.829 21.426 −10.956 1.00 32.61 C ATOM 1873 O ARG B 60 6.119 20.423 −10.962 1.00 30.60 O ATOM 1874 CB ARG B 60 6.906 22.698 −8.827 1.00 34.46 C ATOM 1875 CG ARG B 60 7.532 22.962 −7.477 1.00 39.36 C ATOM 1876 CD ARG B 60 6.600 23.818 −6.646 1.00 40.85 C ATOM 1877 NE ARG B 60 6.420 25.144 −7.230 1.00 43.82 N ATOM 1878 CZ ARG B 60 5.268 25.811 −7.240 1.00 45.46 C ATOM 1879 NH1 ARG B 60 4.178 25.277 −6.703 1.00 46.11 N ATOM 1880 NH2 ARG B 60 5.209 27.024 −7.774 1.00 45.70 N ATOM 1881 N SER B 61 6.891 22.268 −11.982 1.00 32.55 N ATOM 1882 CA SER B 61 6.087 22.077 −13.180 1.00 32.56 C ATOM 1883 C SER B 61 6.582 20.958 −14.069 1.00 33.24 C ATOM 1884 O SER B 61 5.876 20.531 −14.977 1.00 33.15 O ATOM 1885 CB SER B 61 6.030 23.377 −13.982 1.00 32.90 C ATOM 1886 OG SER B 61 7.334 23.847 −14.264 1.00 37.70 O ATOM 1887 N LEU B 62 7.794 20.479 −13.812 1.00 34.16 N ATOM 1888 CA LEU B 62 8.351 19.406 −14.623 1.00 34.43 C ATOM 1889 C LEU B 62 8.135 18.057 −13.942 1.00 34.16 C ATOM 1890 O LEU B 62 8.525 17.013 −14.471 1.00 35.02 O ATOM 1891 CB LEU B 62 9.845 19.660 −14.880 1.00 34.58 C ATOM 1892 CG LEU B 62 10.184 20.900 −15.733 1.00 34.56 C ATOM 1893 CD1 LEU B 62 11.690 21.212 −15.675 1.00 30.95 C ATOM 1894 CD2 LEU B 62 9.749 20.660 −17.171 1.00 30.64 C ATOM 1895 N ALA B 63 7.506 18.086 −12.767 1.00 32.33 N ATOM 1896 CA ALA B 63 7.219 16.863 −12.016 1.00 31.38 C ATOM 1897 C ALA B 63 5.962 16.280 −12.620 1.00 29.97 C ATOM 1898 O ALA B 63 5.098 17.024 −13.064 1.00 29.65 O ATOM 1899 CB ALA B 63 6.990 17.180 −10.546 1.00 29.71 C ATOM 1900 N GLY B 64 5.856 14.958 −12.649 1.00 30.09 N ATOM 1901 CA GLY B 64 4.669 14.352 −13.230 1.00 31.03 C ATOM 1902 C GLY B 64 4.907 13.063 −13.992 1.00 30.84 C ATOM 1903 O GLY B 64 5.973 12.470 −13.893 1.00 31.57 O ATOM 1904 N ARG B 65 3.904 12.629 −14.751 1.00 32.11 N ATOM 1905 CA ARG B 65 3.989 11.394 −15.524 1.00 32.82 C ATOM 1906 C ARG B 65 4.507 11.616 −16.939 1.00 32.28 C ATOM 1907 O ARG B 65 4.125 12.570 −17.615 1.00 30.19 O ATOM 1908 CB ARG B 65 2.607 10.723 −15.619 1.00 36.40 C ATOM 1909 CG ARG B 65 1.953 10.363 −14.288 1.00 43.71 C ATOM 1910 CD ARG B 65 0.496  9.916 −14.485 1.00 49.91 C ATOM 1911 NE ARG B 65 −0.343 10.939 −15.132 1.00 55.98 N ATOM 1912 CZ ARG B 65 −0.729 12.085 −14.568 1.00 56.48 C ATOM 1913 NH1 ARG B 65 −0.363 12.381 −13.329 1.00 56.81 N ATOM 1914 NH2 ARG B 65 −1.476 12.946 −15.247 1.00 57.34 N ATOM 1915 N TYR B 66 5.375 10.719 −17.389 1.00 32.29 N ATOM 1916 CA TYR B 66 5.912 10.792 −18.744 1.00 32.24 C ATOM 1917 C TYR B 66 5.839  9.410 −19.380 1.00 32.50 C ATOM 1918 O TYR B 66 5.912  8.386 −18.696 1.00 33.19 O ATOM 1919 CB TYR B 66 7.382 11.242 −18.758 1.00 32.18 C ATOM 1920 CG TYR B 66 7.638 12.669 −18.340 1.00 31.72 C ATOM 1921 CD1 TYR B 66 7.489 13.063 −17.018 1.00 31.85 C ATOM 1922 CD2 TYR B 66 8.077 13.622 −19.268 1.00 33.40 C ATOM 1923 CE1 TYR B 66 7.775 14.368 −16.619 1.00 33.39 C ATOM 1924 CE2 TYR B 66 8.368 14.932 −18.877 1.00 31.83 C ATOM 1925 CZ TYR B 66 8.219 15.292 −17.552 1.00 32.95 C ATOM 1926 OH TYR B 66 8.548 16.561 −17.137 1.00 32.82 O ATOM 1927 N ARG B 67 5.677  9.396 −20.693 1.00 32.57 N ATOM 1928 CA ARG B 67 5.645  8.163 −21.463 1.00 33.51 C ATOM 1929 C ARG B 67 6.338  8.503 −22.768 1.00 32.98 C ATOM 1930 O ARG B 67 6.443  9.672 −23.144 1.00 30.51 O ATOM 1931 CB ARG B 67 4.211  7.697 −21.759 1.00 36.41 C ATOM 1932 CG ARG B 67 3.528  6.892 −20.655 1.00 40.33 C ATOM 1933 CD ARG B 67 2.127  6.458 −21.102 1.00 42.99 C ATOM 1934 NE ARG B 67 1.357  5.757 −20.070 1.00 44.99 N ATOM 1935 CZ ARG B 67 1.556  4.492 −19.700 1.00 47.59 C ATOM 1936 NH1 ARG B 67 2.507  3.761 −20.265 1.00 48.09 N ATOM 1937 NH2 ARG B 67 0.789  3.947 −18.770 1.00 49.44 N ATOM 1938 N CYS B 68 6.842  7.483 −23.441 1.00 32.89 N ATOM 1939 CA CYS B 68 7.485  7.690 −24.713 1.00 34.04 C ATOM 1940 C CYS B 68 7.179  6.484 −25.575 1.00 33.22 C ATOM 1941 O CYS B 68 6.887  5.400 −25.074 1.00 31.84 O ATOM 1942 CB CYS B 68 8.995  7.892 −24.545 1.00 34.86 C ATOM 1943 SG CYS B 68 9.988  6.416 −24.149 1.00 43.06 S ATOM 1944 N SER B 69 7.201  6.698 −26.881 1.00 34.40 N ATOM 1945 CA SER B 69 6.933  5.642 −27.834 1.00 34.47 C ATOM 1946 C SER B 69 7.866  5.916 −28.993 1.00 34.78 C ATOM 1947 O SER B 69 8.552  6.937 −29.009 1.00 34.49 O ATOM 1948 CB SER B 69 5.471  5.697 −28.279 1.00 31.93 C ATOM 1949 OG SER B 69 4.608  5.634 −27.157 1.00 33.17 O ATOM 1950 N TYR B 70 7.918  5.001 −29.946 1.00 34.98 N ATOM 1951 CA TYR B 70 8.782  5.192 −31.089 1.00 35.39 C ATOM 1952 C TYR B 70 8.123  4.556 −32.284 1.00 36.41 C ATOM 1953 O TYR B 70 7.224  3.723 −32.147 1.00 35.28 O ATOM 1954 CB TYR B 70 10.153  4.556 −30.845 1.00 37.00 C ATOM 1955 CG TYR B 70 10.122  3.045 −30.765 1.00 37.11 C ATOM 1956 CD1 TYR B 70 10.076  2.264 −31.918 1.00 34.86 C ATOM 1957 CD2 TYR B 70 10.105  2.398 −29.533 1.00 36.05 C ATOM 1958 CE1 TYR B 70 10.009  0.878 −31.844 1.00 33.88 C ATOM 1959 CE2 TYR B 70 10.041  1.017 −29.452 1.00 36.63 C ATOM 1960 CZ TYR B 70 9.990  0.260 −30.612 1.00 34.87 C ATOM 1961 OH TYR B 70 9.887 −1.113 −30.523 1.00 37.10 O ATOM 1962 N GLN B 71 8.581  4.962 −33.457 1.00 37.92 N ATOM 1963 CA GLN B 71 8.052  4.451 −34.700 1.00 40.43 C ATOM 1964 C GLN B 71 9.158  3.841 −35.552 1.00 41.44 C ATOM 1965 O GLN B 71 10.226  4.437 −35.730 1.00 40.57 O ATOM 1966 CB GLN B 71 7.372  5.584 −35.469 1.00 40.85 C ATOM 1967 CG GLN B 71 6.785  5.164 −36.792 1.00 42.20 C ATOM 1968 CD GLN B 71 6.223  6.331 −37.563 1.00 43.75 C ATOM 1969 OE1 GLN B 71 6.877  7.367 −37.719 1.00 46.07 O ATOM 1970 NE2 GLN B 71 5.009  6.171 −38.064 1.00 43.24 N ATOM 1971 N ASN B 72 8.891  2.638 −36.052 1.00 42.82 N ATOM 1972 CA ASN B 72 9.811  1.921 −36.926 1.00 45.36 C ATOM 1973 C ASN B 72 8.975  1.573 −38.153 1.00 46.67 C ATOM 1974 O ASN B 72 8.005  0.816 −38.059 1.00 46.38 O ATOM 1975 CB ASN B 72 10.330  0.645 −36.262 1.00 46.04 C ATOM 1976 CG ASN B 72 11.345 −0.087 −37.129 1.00 50.17 C ATOM 1977 OD1 ASN B 72 11.935 −1.089 −36.715 1.00 52.09 O ATOM 1978 ND2 ASN B 72 11.553  0.413 −38.343 1.00 51.01 N ATOM 1979 N GLY B 73 9.350  2.124 −39.302 1.00 46.34 N ATOM 1980 CA GLY B 73 8.573  1.890 −40.499 1.00 49.02 C ATOM 1981 C GLY B 73 7.321  2.736 −40.346 1.00 50.74 C ATOM 1982 O GLY B 73 7.393  3.907 −39.965 1.00 51.62 O ATOM 1983 N SER B 74 6.163  2.163 −40.635 1.00 51.85 N ATOM 1984 CA SER B 74 4.921  2.913 −40.482 1.00 52.68 C ATOM 1985 C SER B 74 4.220  2.420 −39.221 1.00 50.54 C ATOM 1986 O SER B 74 3.030  2.658 −39.020 1.00 50.61 O ATOM 1987 CB SER B 74 4.024  2.726 −41.717 1.00 52.89 C ATOM 1988 OG SER B 74 3.963  1.365 −42.102 1.00 54.68 O ATOM 1989 N LEU B 75 4.987  1.744 −38.368 1.00 48.26 N ATOM 1990 CA LEU B 75 4.470  1.191 −37.122 1.00 46.98 C ATOM 1991 C LEU B 75 4.938  1.889 −35.846 1.00 46.67 C ATOM 1992 O LEU B 75 6.131  2.149 −35.659 1.00 46.73 O ATOM 1993 CB LEU B 75 4.822 −0.295 −37.032 1.00 44.75 C ATOM 1994 CG LEU B 75 3.725 −1.280 −37.442 1.00 45.29 C ATOM 1995 CD1 LEU B 75 3.090 −0.844 −38.756 1.00 46.02 C ATOM 1996 CD2 LEU B 75 4.322 −2.675 −37.553 1.00 44.02 C ATOM 1997 N TRP B 76 3.977  2.197 −34.975 1.00 44.73 N ATOM 1998 CA TRP B 76 4.266  2.818 −33.689 1.00 41.77 C ATOM 1999 C TRP B 76 4.319  1.694 −32.671 1.00 40.76 C ATOM 2000 O TRP B 76 3.655  0.668 −32.827 1.00 41.45 O ATOM 2001 CB TRP B 76 3.179  3.823 −33.293 1.00 41.00 C ATOM 2002 CG TRP B 76 3.394  5.185 −33.889 1.00 43.16 C ATOM 2003 CD1 TRP B 76 2.787  5.700 −34.997 1.00 43.36 C ATOM 2004 CD2 TRP B 76 4.338  6.177 −33.453 1.00 41.30 C ATOM 2005 NE1 TRP B 76 3.295  6.945 −35.280 1.00 42.94 N ATOM 2006 CE2 TRP B 76 4.249  7.262 −34.350 1.00 41.74 C ATOM 2007 CE3 TRP B 76 5.251  6.250 −32.395 1.00 40.40 C ATOM 2008 CZ2 TRP B 76 5.041  8.412 −34.225 1.00 43.00 C ATOM 2009 CZ3 TRP B 76 6.040  7.392 −32.268 1.00 43.40 C ATOM 2010 CH2 TRP B 76 5.927  8.459 −33.183 1.00 43.59 C ATOM 2011 N SER B 77 5.118  1.880 −31.634 1.00 38.46 N ATOM 2012 CA SER B 77 5.261  0.867 −30.608 1.00 38.11 C ATOM 2013 C SER B 77 4.255  1.112 −29.496 1.00 38.45 C ATOM 2014 O SER B 77 3.501  2.095 −29.525 1.00 38.99 O ATOM 2015 CB SER B 77 6.657  0.941 −30.012 1.00 37.04 C ATOM 2016 OG SER B 77 6.788  2.155 −29.288 1.00 37.48 O ATOM 2017 N LEU B 78 4.245  0.209 −28.520 1.00 36.00 N ATOM 2018 CA LEU B 78 3.377  0.368 −27.371 1.00 35.64 C ATOM 2019 C LEU B 78 4.073  1.446 −26.570 1.00 37.10 C ATOM 2020 O LEU B 78 5.282  1.655 −26.712 1.00 38.40 O ATOM 2021 CB LEU B 78 3.320 −0.910 −26.525 1.00 33.61 C ATOM 2022 CG LEU B 78 2.457 −2.096 −26.977 1.00 34.02 C ATOM 2023 CD1 LEU B 78 2.614 −3.244 −25.983 1.00 31.24 C ATOM 2024 CD2 LEU B 78 0.998 −1.670 −27.067 1.00 28.27 C ATOM 2025 N PRO B 79 3.327  2.167 −25.732 1.00 36.74 N ATOM 2026 CA PRO B 79 4.002  3.200 −24.952 1.00 37.06 C ATOM 2027 C PRO B 79 4.833  2.545 −23.841 1.00 37.13 C ATOM 2028 O PRO B 79 4.528  1.442 −23.394 1.00 36.87 O ATOM 2029 CB PRO B 79 2.836  4.031 −24.417 1.00 36.14 C ATOM 2030 CG PRO B 79 1.767  3.012 −24.243 1.00 37.20 C ATOM 2031 CD PRO B 79 1.873  2.202 −25.515 1.00 35.23 C ATOM 2032 N SER B 80 5.893  3.216 −23.414 1.00 37.03 N ATOM 2033 CA SER B 80 6.739  2.686 −22.351 1.00 36.95 C ATOM 2034 C SER B 80 5.910  2.754 −21.088 1.00 37.13 C ATOM 2035 O SER B 80 4.862  3.406 −21.077 1.00 37.41 O ATOM 2036 CB SER B 80 7.977  3.571 −22.167 1.00 37.23 C ATOM 2037 OG SER B 80 7.618  4.829 −21.610 1.00 34.55 O ATOM 2038 N ASP B 81 6.364  2.099 −20.024 1.00 36.59 N ATOM 2039 CA ASP B 81 5.635  2.184 −18.764 1.00 37.87 C ATOM 2040 C ASP B 81 5.724  3.660 −18.391 1.00 39.02 C ATOM 2041 O ASP B 81 6.663  4.352 −18.800 1.00 40.86 O ATOM 2042 CB ASP B 81 6.293  1.328 −17.679 1.00 37.52 C ATOM 2043 CG ASP B 81 6.361 −0.140 −18.054 1.00 38.73 C ATOM 2044 OD1 ASP B 81 5.379 −0.663 −18.631 1.00 36.87 O ATOM 2045 OD2 ASP B 81 7.399 −0.770 −17.762 1.00 40.96 O ATOM 2046 N GLN B 82 4.762  4.173 −17.642 1.00 38.65 N ATOM 2047 CA GLN B 82 4.852  5.578 −17.305 1.00 41.64 C ATOM 2048 C GLN B 82 5.951  5.853 −16.282 1.00 40.81 C ATOM 2049 O GLN B 82 6.064  5.173 −15.259 1.00 38.29 O ATOM 2050 CB GLN B 82 3.516  6.114 −16.776 1.00 44.48 C ATOM 2051 CG GLN B 82 2.954  5.354 −15.596 1.00 50.45 C ATOM 2052 CD GLN B 82 1.951  6.174 −14.813 1.00 54.07 C ATOM 2053 OE1 GLN B 82 1.178  6.950 −15.386 1.00 57.55 O ATOM 2054 NE2 GLN B 82 1.949  6.001 −13.494 1.00 55.77 N ATOM 2055 N LEU B 83 6.776  6.842 −16.593 1.00 39.74 N ATOM 2056 CA LEU B 83 7.832  7.260 −15.694 1.00 40.28 C ATOM 2057 C LEU B 83 7.196  8.305 −14.787 1.00 40.26 C ATOM 2058 O LEU B 83 6.693  9.328 −15.261 1.00 40.58 O ATOM 2059 CB LEU B 83 8.981  7.901 −16.468 1.00 41.25 C ATOM 2060 CG LEU B 83 10.058  8.563 −15.610 1.00 41.81 C ATOM 2061 CD1 LEU B 83 10.890  7.510 −14.897 1.00 42.53 C ATOM 2062 CD2 LEU B 83 10.938  9.403 −16.495 1.00 43.98 C ATOM 2063 N GLU B 84 7.188  8.046 −13.489 1.00 38.89 N ATOM 2064 CA GLU B 84 6.619  9.008 −12.566 1.00 40.60 C ATOM 2065 C GLU B 84 7.735  9.887 −12.005 1.00 38.36 C ATOM 2066 O GLU B 84 8.443  9.489 −11.078 1.00 37.30 O ATOM 2067 CB GLU B 84 5.857  8.270 −11.464 1.00 43.46 C ATOM 2068 CG GLU B 84 4.727  7.424 −12.046 1.00 48.78 C ATOM 2069 CD GLU B 84 3.884  6.731 −10.997 1.00 51.88 C ATOM 2070 OE1 GLU B 84 3.354  7.424 −10.100 1.00 53.57 O ATOM 2071 OE2 GLU B 84 3.741  5.493 −11.081 1.00 53.36 O ATOM 2072 N LEU B 85 7.898 11.071 −12.601 1.00 35.07 N ATOM 2073 CA LEU B 85 8.928 12.020 −12.191 1.00 33.81 C ATOM 2074 C LEU B 85 8.505 12.827 −10.962 1.00 34.27 C ATOM 2075 O LEU B 85 7.646 13.710 −11.033 1.00 33.16 O ATOM 2076 CB LEU B 85 9.274 12.968 −13.343 1.00 31.31 C ATOM 2077 CG LEU B 85 10.539 13.812 −13.121 1.00 31.62 C ATOM 2078 CD1 LEU B 85 11.728 12.874 −12.900 1.00 29.49 C ATOM 2079 CD2 LEU B 85 10.803 14.724 −14.316 1.00 27.08 C ATOM 2080 N VAL B 86 9.140 12.518 −9.838 1.00 34.91 N ATOM 2081 CA VAL B 86 8.848 13.164 −8.570 1.00 34.42 C ATOM 2082 C VAL B 86 9.847 14.257 −8.235 1.00 35.16 C ATOM 2083 O VAL B 86 11.047 14.111 −8.459 1.00 36.25 O ATOM 2084 CB VAL B 86 8.854 12.127 −7.418 1.00 34.56 C ATOM 2085 CG1 VAL B 86 8.622 12.814 −6.088 1.00 34.59 C ATOM 2086 CG2 VAL B 86 7.794 11.071 −7.667 1.00 32.20 C ATOM 2087 N ALA B 87 9.328 15.357 −7.699 1.00 35.57 N ATOM 2088 CA ALA B 87 10.138 16.493 −7.287 1.00 33.90 C ATOM 2089 C ALA B 87 10.167 16.489 −5.764 1.00 35.74 C ATOM 2090 O ALA B 87 9.118 16.429 −5.125 1.00 36.03 O ATOM 2091 CB ALA B 87 9.511 17.793 −7.794 1.00 31.72 C ATOM 2092 N THR B 88 11.354 16.526 −5.168 1.00 37.16 N ATOM 2093 CA THR B 88 11.410 16.543 −3.709 1.00 36.85 C ATOM 2094 C THR B 88 11.909 17.903 −3.251 1.00 37.13 C ATOM 2095 O THR B 88 12.505 18.651 −4.035 1.00 38.01 O ATOM 2096 CB THR B 88 12.341 15.440 −3.121 1.00 36.62 C ATOM 2097 OG1 THR B 88 13.708 15.793 −3.346 1.00 35.45 O ATOM 2098 CG2 THR B 88 12.052 14.088 −3.748 1.00 31.60 C ATOM 2099 N GLY B 89 11.657 18.210 −1.981 1.00 37.81 N ATOM 2100 CA GLY B 89 12.062 19.480 −1.410 1.00 36.33 C ATOM 2101 C GLY B 89 11.000 20.529 −1.674 1.00 36.04 C ATOM 2102 O GLY B 89 11.243 21.722 −1.546 1.00 35.58 O ATOM 2103 N VAL B 90 9.809 20.085 −2.042 1.00 36.69 N ATOM 2104 CA VAL B 90 8.728 21.018 −2.339 1.00 39.65 C ATOM 2105 C VAL B 90 8.102 21.536 −1.054 1.00 41.20 C ATOM 2106 O VAL B 90 7.410 22.551 −1.057 1.00 41.81 O ATOM 2107 CB VAL B 90 7.622 20.343 −3.186 1.00 37.77 C ATOM 2108 CG1 VAL B 90 6.570 21.360 −3.577 1.00 35.16 C ATOM 2109 CG2 VAL B 90 8.234 19.694 −4.411 1.00 36.57 C ATOM 2110 N PHE B 91 8.354 20.835 0.045 1.00 42.11 N ATOM 2111 CA PHE B 91 7.784 21.218 1.330 1.00 42.29 C ATOM 2112 C PHE B 91 8.768 20.972 2.465 1.00 42.73 C ATOM 2113 O PHE B 91 9.805 20.324 2.273 1.00 41.46 O ATOM 2114 CB PHE B 91 6.519 20.400 1.590 1.00 42.07 C ATOM 2115 CG PHE B 91 5.524 20.445 0.468 1.00 40.04 C ATOM 2116 CD1 PHE B 91 4.788 21.603 0.216 1.00 40.06 C ATOM 2117 CD2 PHE B 91 5.303 19.321 −0.319 1.00 38.76 C ATOM 2118 CE1 PHE B 91 3.835 21.637 −0.808 1.00 39.59 C ATOM 2119 CE2 PHE B 91 4.359 19.340 −1.340 1.00 38.83 C ATOM 2120 CZ PHE B 91 3.622 20.500 −1.586 1.00 40.01 C ATOM 2121 N ALA B 92 8.434 21.483 3.649 1.00 41.81 N ATOM 2122 CA ALA B 92 9.286 21.281 4.816 1.00 40.93 C ATOM 2123 C ALA B 92 9.356 19.782 5.073 1.00 39.54 C ATOM 2124 O ALA B 92 8.374 19.066 4.887 1.00 40.28 O ATOM 2125 CB ALA B 92 8.712 21.996 6.024 1.00 37.55 C ATOM 2126 N LYS B 93 10.520 19.308 5.487 1.00 39.15 N ATOM 2127 CA LYS B 93 10.700 17.890 5.747 1.00 40.51 C ATOM 2128 C LYS B 93 9.899 17.395 6.948 1.00 39.57 C ATOM 2129 O LYS B 93 9.662 18.133 7.902 1.00 40.61 O ATOM 2130 CB LYS B 93 12.183 17.585 5.969 1.00 40.33 C ATOM 2131 CG LYS B 93 12.757 18.184 7.235 1.00 39.37 C ATOM 2132 CD LYS B 93 14.257 18.005 7.277 1.00 40.32 C ATOM 2133 CE LYS B 93 14.855 18.769 8.440 1.00 43.72 C ATOM 2134 NZ LYS B 93 16.343 18.828 8.367 1.00 46.76 N ATOM 2135 N PRO B 94 9.436 16.141 6.895 1.00 38.93 N ATOM 2136 CA PRO B 94 8.673 15.613 8.028 1.00 39.13 C ATOM 2137 C PRO B 94 9.698 15.041 9.025 1.00 40.61 C ATOM 2138 O PRO B 94 10.908 15.110 8.780 1.00 41.35 O ATOM 2139 CB PRO B 94 7.802 14.543 7.377 1.00 37.90 C ATOM 2140 CG PRO B 94 8.711 14.000 6.292 1.00 36.34 C ATOM 2141 CD PRO B 94 9.371 15.237 5.729 1.00 36.07 C ATOM 2142 N SER B 95 9.239 14.498 10.147 1.00 40.91 N ATOM 2143 CA SER B 95 10.175 13.929 11.106 1.00 40.87 C ATOM 2144 C SER B 95 9.938 12.427 11.201 1.00 39.68 C ATOM 2145 O SER B 95 8.799 11.965 11.168 1.00 39.79 O ATOM 2146 CB SER B 95 10.010 14.582 12.480 1.00 42.95 C ATOM 2147 OG SER B 95 8.742 14.280 13.036 1.00 48.73 O ATOM 2148 N LEU B 96 11.027 11.675 11.299 1.00 38.33 N ATOM 2149 CA LEU B 96 10.968 10.227 11.389 1.00 39.19 C ATOM 2150 C LEU B 96 11.433  9.799 12.783 1.00 41.03 C ATOM 2151 O LEU B 96 12.472 10.245 13.268 1.00 41.11 O ATOM 2152 CB LEU B 96 11.862  9.609 10.306 1.00 37.60 C ATOM 2153 CG LEU B 96 11.863  8.091 10.140 1.00 36.31 C ATOM 2154 CD1 LEU B 96 10.435  7.585 10.042 1.00 37.12 C ATOM 2155 CD2 LEU B 96 12.656  7.717 8.903 1.00 33.31 C ATOM 2156 N SER B 97 10.656  8.932 13.422 1.00 41.91 N ATOM 2157 CA SER B 97 10.968  8.472 14.766 1.00 44.55 C ATOM 2158 C SER B 97 10.405  7.080 14.948 1.00 45.76 C ATOM 2159 O SER B 97 9.621  6.619 14.121 1.00 47.36 O ATOM 2160 CB SER B 97 10.317  9.396 15.787 1.00 44.68 C ATOM 2161 OG SER B 97 8.903  9.355 15.646 1.00 45.41 O ATOM 2162 N ALA B 98 10.788  6.420 16.036 1.00 46.70 N ATOM 2163 CA ALA B 98 10.304  5.077 16.307 1.00 49.73 C ATOM 2164 C ALA B 98 9.039  5.130 17.140 1.00 53.40 C ATOM 2165 O ALA B 98 8.696  6.231 17.626 1.00 56.05 O ATOM 2166 CB ALA B 98 11.354  4.284 17.032 1.00 49.94 C ATOM 2167 N GLY B 108 13.701 −7.552 15.288 1.00 75.24 N ATOM 2168 CA GLY B 108 12.736 −8.586 14.808 1.00 74.51 C ATOM 2169 C GLY B 108 11.605 −7.989 13.993 1.00 74.31 C ATOM 2170 O GLY B 108 11.044 −8.649 13.118 1.00 74.74 O ATOM 2171 N ASP B 109 11.272 −6.734 14.284 1.00 73.60 N ATOM 2172 CA ASP B 109 10.204 −6.024 13.588 1.00 72.12 C ATOM 2173 C ASP B 109 10.015 −4.675 14.278 1.00 70.41 C ATOM 2174 O ASP B 109 9.642 −4.620 15.452 1.00 69.80 O ATOM 2175 CB ASP B 109 8.897 −6.826 13.651 1.00 73.57 C ATOM 2176 CG ASP B 109 7.915 −6.434 12.558 1.00 75.12 C ATOM 2177 OD1 ASP B 109 7.655 −5.221 12.406 1.00 76.59 O ATOM 2178 OD2 ASP B 109 7.402 −7.336 11.852 1.00 74.69 O ATOM 2179 N VAL B 110 10.270 −3.590 13.549 1.00 67.99 N ATOM 2180 CA VAL B 110 10.143 −2.247 14.112 1.00 65.35 C ATOM 2181 C VAL B 110 9.127 −1.369 13.383 1.00 63.44 C ATOM 2182 O VAL B 110 8.923 −1.505 12.179 1.00 63.89 O ATOM 2183 CB VAL B 110 11.508 −1.528 14.106 1.00 64.02 C ATOM 2184 CG1 VAL B 110 11.396 −0.187 14.797 1.00 63.71 C ATOM 2185 CG2 VAL B 110 12.543 −2.389 14.798 1.00 65.11 C ATOM 2186 N THR B 111 8.485 −0.472 14.124 1.00 61.16 N ATOM 2187 CA THR B 111 7.506  0.437 13.541 1.00 59.52 C ATOM 2188 C THR B 111 7.966  1.883 13.682 1.00 59.20 C ATOM 2189 O THR B 111 8.264  2.349 14.781 1.00 58.49 O ATOM 2190 CB THR B 111 6.130  0.300 14.212 1.00 58.72 C ATOM 2191 OG1 THR B 111 5.587 −0.995 13.937 1.00 58.87 O ATOM 2192 CG2 THR B 111 5.184  1.358 13.686 1.00 57.77 C ATOM 2193 N LEU B 112 8.022  2.586 12.556 1.00 58.66 N ATOM 2194 CA LEU B 112 8.442  3.980 12.536 1.00 57.70 C ATOM 2195 C LEU B 112 7.248  4.837 12.144 1.00 57.95 C ATOM 2196 O LEU B 112 6.329  4.366 11.474 1.00 58.52 O ATOM 2197 CB LEU B 112 9.561  4.175 11.515 1.00 55.80 C ATOM 2198 CG LEU B 112 10.679  3.134 11.567 1.00 53.88 C ATOM 2199 CD1 LEU B 112 11.682  3.405 10.466 1.00 51.07 C ATOM 2200 CD2 LEU B 112 11.343  3.173 12.929 1.00 53.84 C ATOM 2201 N GLN B 113 7.252  6.092 12.569 1.00 57.73 N ATOM 2202 CA GLN B 113 6.158  6.985 12.229 1.00 57.58 C ATOM 2203 C GLN B 113 6.705  8.244 11.571 1.00 56.64 C ATOM 2204 O GLN B 113 7.596  8.908 12.104 1.00 55.57 O ATOM 2205 CB GLN B 113 5.343  7.347 13.474 1.00 59.03 C ATOM 2206 CG GLN B 113 6.048  8.255 14.459 1.00 62.63 C ATOM 2207 CD GLN B 113 5.119  8.747 15.558 1.00 64.92 C ATOM 2208 OE1 GLN B 113 3.991  9.175 15.291 1.00 65.46 O ATOM 2209 NE2 GLN B 113 5.594  8.702 16.801 1.00 65.15 N ATOM 2210 N CYS B 114 6.177  8.553 10.394 1.00 56.49 N ATOM 2211 CA CYS B 114 6.602  9.729 9.655 1.00 57.78 C ATOM 2212 C CYS B 114 5.614 10.837 9.992 1.00 58.72 C ATOM 2213 O CYS B 114 4.463 10.812 9.561 1.00 58.27 O ATOM 2214 CB CYS B 114 6.604  9.427 8.154 1.00 55.50 C ATOM 2215 SG CYS B 114 7.363 10.705 7.099 1.00 55.13 S ATOM 2216 N GLN B 115 6.075 11.802 10.777 1.00 60.98 N ATOM 2217 CA GLN B 115 5.234 12.906 11.211 1.00 64.67 C ATOM 2218 C GLN B 115 5.429 14.172 10.398 1.00 65.95 C ATOM 2219 O GLN B 115 6.535 14.708 10.316 1.00 65.63 O ATOM 2220 CB GLN B 115 5.495 13.193 12.691 1.00 66.32 C ATOM 2221 CG GLN B 115 4.862 14.467 13.209 1.00 71.16 C ATOM 2222 CD GLN B 115 4.994 14.604 14.715 1.00 73.92 C ATOM 2223 OE1 GLN B 115 4.430 13.810 15.471 1.00 74.83 O ATOM 2224 NE2 GLN B 115 5.747 15.609 15.159 1.00 75.68 N ATOM 2225 N THR B 116 4.333 14.645 9.810 1.00 68.24 N ATOM 2226 CA THR B 116 4.333 15.851 8.990 1.00 70.06 C ATOM 2227 C THR B 116 3.323 16.858 9.525 1.00 72.02 C ATOM 2228 O THR B 116 2.468 16.501 10.331 1.00 72.98 O ATOM 2229 CB THR B 116 3.969 15.519 7.545 1.00 70.02 C ATOM 2230 OG1 THR B 116 3.854 16.734 6.795 1.00 71.00 O ATOM 2231 CG2 THR B 116 2.657 14.746 7.493 1.00 68.51 C ATOM 2232 N ARG B 117 3.405 18.105 9.064 1.00 74.47 N ATOM 2233 CA ARG B 117 2.495 19.151 9.536 1.00 76.88 C ATOM 2234 C ARG B 117 1.445 19.654 8.542 1.00 77.42 C ATOM 2235 O ARG B 117 0.332 19.993 8.940 1.00 77.95 O ATOM 2236 CB ARG B 117 3.297 20.355 10.052 1.00 78.20 C ATOM 2237 CG ARG B 117 4.175 20.054 11.258 1.00 80.53 C ATOM 2238 CD ARG B 117 4.908 21.293 11.761 1.00 82.19 C ATOM 2239 NE ARG B 117 4.001 22.290 12.327 1.00 84.35 N ATOM 2240 CZ ARG B 117 4.398 23.422 12.904 1.00 85.06 C ATOM 2241 NH1 ARG B 117 5.692 23.706 12.994 1.00 85.22 N ATOM 2242 NH2 ARG B 117 3.503 24.270 13.396 1.00 84.53 N ATOM 2243 N TYR B 118 1.793 19.711 7.260 1.00 78.09 N ATOM 2244 CA TYR B 118 0.868 20.207 6.237 1.00 78.10 C ATOM 2245 C TYR B 118 −0.444 19.433 6.116 1.00 77.33 C ATOM 2246 O TYR B 118 −1.312 19.795 5.318 1.00 77.27 O ATOM 2247 CB TYR B 118 1.535 20.214 4.859 1.00 79.28 C ATOM 2248 CG TYR B 118 2.735 21.122 4.710 1.00 79.72 C ATOM 2249 CD1 TYR B 118 4.012 20.695 5.075 1.00 78.94 C ATOM 2250 CD2 TYR B 118 2.599 22.396 4.156 1.00 79.35 C ATOM 2251 CE1 TYR B 118 5.123 21.511 4.881 1.00 79.38 C ATOM 2252 CE2 TYR B 118 3.702 23.218 3.962 1.00 78.91 C ATOM 2253 CZ TYR B 118 4.960 22.770 4.322 1.00 78.85 C ATOM 2254 OH TYR B 118 6.053 23.572 4.098 1.00 78.76 O ATOM 2255 N GLY B 119 −0.591 18.365 6.887 1.00 76.06 N ATOM 2256 CA GLY B 119 −1.812 17.588 6.801 1.00 74.06 C ATOM 2257 C GLY B 119 −1.867 16.717 5.553 1.00 72.49 C ATOM 2258 O GLY B 119 −2.952 16.405 5.057 1.00 73.00 O ATOM 2259 N PHE B 120 −0.703 16.330 5.035 1.00 68.91 N ATOM 2260 CA PHE B 120 −0.655 15.477 3.857 1.00 64.91 C ATOM 2261 C PHE B 120 −1.249 14.140 4.264 1.00 62.81 C ATOM 2262 O PHE B 120 −1.474 13.900 5.444 1.00 62.60 O ATOM 2263 CB PHE B 120 0.789 15.278 3.388 1.00 64.62 C ATOM 2264 CG PHE B 120 1.462 16.538 2.919 1.00 63.89 C ATOM 2265 CD1 PHE B 120 0.940 17.272 1.859 1.00 64.15 C ATOM 2266 CD2 PHE B 120 2.627 16.986 3.530 1.00 63.97 C ATOM 2267 CE1 PHE B 120 1.574 18.440 1.415 1.00 64.33 C ATOM 2268 CE2 PHE B 120 3.267 18.149 3.094 1.00 63.89 C ATOM 2269 CZ PHE B 120 2.739 18.878 2.035 1.00 62.57 C ATOM 2270 N ASP B 121 −1.498 13.270 3.291 1.00 61.19 N ATOM 2271 CA ASP B 121 −2.073 11.956 3.569 1.00 59.12 C ATOM 2272 C ASP B 121 −1.234 10.838 2.952 1.00 56.90 C ATOM 2273 O ASP B 121 −1.655  9.683 2.898 1.00 54.60 O ATOM 2274 CB ASP B 121 −3.504 11.885 3.022 1.00 61.18 C ATOM 2275 CG ASP B 121 −3.558 11.961 1.504 1.00 63.60 C ATOM 2276 OD1 ASP B 121 −3.103 12.982 0.936 1.00 63.05 O ATOM 2277 OD2 ASP B 121 −4.059 10.993 0.881 1.00 64.96 O ATOM 2278 N GLN B 122 −0.042 11.188 2.484 1.00 55.50 N ATOM 2279 CA GLN B 122 0.838 10.208 1.871 1.00 54.56 C ATOM 2280 C GLN B 122 2.232 10.240 2.482 1.00 52.30 C ATOM 2281 O GLN B 122 2.706 11.284 2.932 1.00 50.06 O ATOM 2282 CB GLN B 122 0.907 10.447 0.364 1.00 57.21 C ATOM 2283 CG GLN B 122 −0.393 10.136 −0.355 1.00 60.08 C ATOM 2284 CD GLN B 122 −0.762  8.671 −0.250 1.00 62.43 C ATOM 2285 OE1 GLN B 122 −0.039  7.802 −0.741 1.00 65.28 O ATOM 2286 NE2 GLN B 122 −1.884  8.388 0.397 1.00 63.42 N ATOM 2287 N PHE B 123 2.878  9.077 2.493 1.00 51.09 N ATOM 2288 CA PHE B 123 4.210  8.923 3.060 1.00 49.61 C ATOM 2289 C PHE B 123 5.015  7.895 2.285 1.00 48.55 C ATOM 2290 O PHE B 123 4.475  6.928 1.747 1.00 48.32 O ATOM 2291 CB PHE B 123 4.108  8.472 4.523 1.00 50.13 C ATOM 2292 CG PHE B 123 3.297  9.394 5.381 1.00 52.48 C ATOM 2293 CD1 PHE B 123 3.866 10.547 5.919 1.00 52.56 C ATOM 2294 CD2 PHE B 123 1.937  9.148 5.598 1.00 52.92 C ATOM 2295 CE1 PHE B 123 3.095 11.448 6.661 1.00 54.57 C ATOM 2296 CE2 PHE B 123 1.154 10.042 6.337 1.00 52.34 C ATOM 2297 CZ PHE B 123 1.732 11.192 6.869 1.00 54.45 C ATOM 2298 N ALA B 124 6.318  8.114 2.233 1.00 46.36 N ATOM 2299 CA ALA B 124 7.212  7.201 1.558 1.00 45.13 C ATOM 2300 C ALA B 124 8.424  7.053 2.456 1.00 44.69 C ATOM 2301 O ALA B 124 9.012  8.041 2.878 1.00 42.23 O ATOM 2302 CB ALA B 124 7.622  7.761 0.210 1.00 45.17 C ATOM 2303 N LEU B 125 8.782  5.817 2.761 1.00 46.55 N ATOM 2304 CA LEU B 125 9.937  5.557 3.597 1.00 50.41 C ATOM 2305 C LEU B 125 10.875  4.653 2.827 1.00 52.56 C ATOM 2306 O LEU B 125 10.426  3.739 2.141 1.00 51.97 O ATOM 2307 CB LEU B 125 9.512  4.870 4.896 1.00 51.57 C ATOM 2308 CG LEU B 125 10.645  4.374 5.801 1.00 52.38 C ATOM 2309 CD1 LEU B 125 11.447  5.558 6.322 1.00 51.80 C ATOM 2310 CD2 LEU B 125 10.063  3.570 6.953 1.00 53.36 C ATOM 2311 N TYR B 126 12.175  4.911 2.923 1.00 56.58 N ATOM 2312 CA TYR B 126 13.142  4.070 2.231 1.00 60.64 C ATOM 2313 C TYR B 126 14.460  3.904 2.981 1.00 62.55 C ATOM 2314 O TYR B 126 14.962  4.842 3.612 1.00 61.18 O ATOM 2315 CB TYR B 126 13.436  4.619 0.836 1.00 62.95 C ATOM 2316 CG TYR B 126 14.407  5.774 0.820 1.00 65.41 C ATOM 2317 CD1 TYR B 126 14.010  7.047 1.216 1.00 66.39 C ATOM 2318 CD2 TYR B 126 15.725  5.594 0.396 1.00 67.29 C ATOM 2319 CE1 TYR B 126 14.900  8.119 1.186 1.00 68.96 C ATOM 2320 CE2 TYR B 126 16.628  6.659 0.364 1.00 68.89 C ATOM 2321 CZ TYR B 126 16.208  7.920 0.759 1.00 69.43 C ATOM 2322 OH TYR B 126 17.083  8.984 0.730 1.00 69.26 O ATOM 2323 N LYS B 127 15.006  2.693 2.901 1.00 64.83 N ATOM 2324 CA LYS B 127 16.276  2.359 3.532 1.00 66.32 C ATOM 2325 C LYS B 127 17.350  2.556 2.478 1.00 67.01 C ATOM 2326 O LYS B 127 17.279  1.962 1.407 1.00 67.56 O ATOM 2327 CB LYS B 127 16.284  0.900 4.004 1.00 66.39 C ATOM 2328 CG LYS B 127 17.655  0.419 4.474 1.00 67.65 C ATOM 2329 CD LYS B 127 17.631 −0.983 5.092 1.00 68.47 C ATOM 2330 CE LYS B 127 17.443 −2.094 4.058 1.00 68.91 C ATOM 2331 NZ LYS B 127 16.052 −2.202 3.538 1.00 68.36 N ATOM 2332 N GLU B 128 18.335  3.394 2.772 1.00 68.42 N ATOM 2333 CA GLU B 128 19.403  3.636 1.817 1.00 71.11 C ATOM 2334 C GLU B 128 20.000  2.322 1.333 1.00 72.28 C ATOM 2335 O GLU B 128 20.013  1.328 2.061 1.00 72.79 O ATOM 2336 CB GLU B 128 20.491  4.508 2.443 1.00 71.72 C ATOM 2337 CG GLU B 128 20.117  5.970 2.518 1.00 73.98 C ATOM 2338 CD GLU B 128 21.265  6.833 2.980 1.00 76.25 C ATOM 2339 OE1 GLU B 128 21.639  6.740 4.166 1.00 78.76 O ATOM 2340 OE2 GLU B 128 21.799  7.605 2.155 1.00 78.48 O ATOM 2341 N GLY B 129 20.474  2.314 0.093 1.00 73.11 N ATOM 2342 CA GLY B 129 21.063  1.107 −0.444 1.00 75.33 C ATOM 2343 C GLY B 129 22.200  0.656 0.450 1.00 76.68 C ATOM 2344 O GLY B 129 22.065 −0.409 1.092 1.00 76.52 O ATOM 2345 N GLU B 138 18.544 −0.856 −0.673 1.00 87.47 N ATOM 2346 CA GLU B 138 17.299 −0.092 −0.962 1.00 87.34 C ATOM 2347 C GLU B 138 16.053 −0.869 −0.567 1.00 86.98 C ATOM 2348 O GLU B 138 16.069 −2.096 −0.491 1.00 86.52 O ATOM 2349 CB GLU B 138 17.220  0.256 −2.451 1.00 88.42 C ATOM 2350 CG GLU B 138 18.197  1.335 −2.916 1.00 89.86 C ATOM 2351 CD GLU B 138 17.929  2.689 −2.278 1.00 90.34 C ATOM 2352 OE1 GLU B 138 18.166  2.828 −1.061 1.00 91.72 O ATOM 2353 OE2 GLU B 138 17.476  3.611 −2.989 1.00 89.89 O ATOM 2354 N ARG B 139 14.977 −0.133 −0.316 1.00 87.81 N ATOM 2355 CA ARG B 139 13.691 −0.711 0.062 1.00 88.91 C ATOM 2356 C ARG B 139 12.697  0.428 0.320 1.00 88.59 C ATOM 2357 O ARG B 139 12.943  1.297 1.161 1.00 88.32 O ATOM 2358 CB ARG B 139 13.834 −1.568 1.327 1.00 90.06 C ATOM 2359 CG ARG B 139 12.765 −2.650 1.472 1.00 91.68 C ATOM 2360 CD ARG B 139 13.006 −3.796 0.487 1.00 94.06 C ATOM 2361 NE ARG B 139 14.241 −4.524 0.790 1.00 95.28 N ATOM 2362 CZ ARG B 139 14.792 −5.442 −0.002 1.00 95.04 C ATOM 2363 NH1 ARG B 139 14.223 −5.755 −1.161 1.00 94.72 N ATOM 2364 NH2 ARG B 139 15.912 −6.049 0.368 1.00 94.22 N ATOM 2365 N TRP B 140 11.581  0.426 −0.406 1.00 87.94 N ATOM 2366 CA TRP B 140 10.569  1.464 −0.241 1.00 87.04 C ATOM 2367 C TRP B 140 9.289  0.993 0.439 1.00 86.95 C ATOM 2368 O TRP B 140 8.877 −0.161 0.309 1.00 86.63 O ATOM 2369 CB TRP B 140 10.222  2.094 −1.593 1.00 86.32 C ATOM 2370 CG TRP B 140 11.308  2.959 −2.121 1.00 86.48 C ATOM 2371 CD1 TRP B 140 12.441  2.552 −2.763 1.00 86.74 C ATOM 2372 CD2 TRP B 140 11.404  4.384 −1.995 1.00 86.21 C ATOM 2373 NE1 TRP B 140 13.240  3.637 −3.043 1.00 87.45 N ATOM 2374 CE2 TRP B 140 12.626  4.773 −2.582 1.00 86.40 C ATOM 2375 CE3 TRP B 140 10.576  5.369 −1.440 1.00 85.13 C ATOM 2376 CZ2 TRP B 140 13.042  6.108 −2.630 1.00 85.50 C ATOM 2377 CZ3 TRP B 140 10.990  6.694 −1.487 1.00 84.34 C ATOM 2378 CH2 TRP B 140 12.212  7.050 −2.078 1.00 84.74 C ATOM 2379 N TYR B 141 8.667  1.912 1.169 1.00 87.34 N ATOM 2380 CA TYR B 141 7.431  1.641 1.884 1.00 87.91 C ATOM 2381 C TYR B 141 6.530  2.864 1.738 1.00 88.25 C ATOM 2382 O TYR B 141 6.791  3.910 2.328 1.00 88.34 O ATOM 2383 CB TYR B 141 7.725  1.392 3.368 1.00 88.48 C ATOM 2384 CG TYR B 141 8.876  0.439 3.626 1.00 89.00 C ATOM 2385 CD1 TYR B 141 8.768 −0.919 3.329 1.00 89.23 C ATOM 2386 CD2 TYR B 141 10.079  0.902 4.158 1.00 89.28 C ATOM 2387 CE1 TYR B 141 9.831 −1.794 3.556 1.00 89.63 C ATOM 2388 CE2 TYR B 141 11.148  0.037 4.388 1.00 90.09 C ATOM 2389 CZ TYR B 141 11.017 −1.309 4.086 1.00 89.71 C ATOM 2390 OH TYR B 141 12.070 −2.166 4.318 1.00 88.28 O ATOM 2391 N ARG B 142 5.481  2.733 0.935 1.00 88.77 N ATOM 2392 CA ARG B 142 4.537  3.824 0.718 1.00 89.75 C ATOM 2393 C ARG B 142 3.271  3.491 1.501 1.00 89.26 C ATOM 2394 O ARG B 142 2.796  2.357 1.451 1.00 89.80 O ATOM 2395 CB ARG B 142 4.226  3.956 −0.781 1.00 90.55 C ATOM 2396 CG ARG B 142 3.288  5.104 −1.157 1.00 91.87 C ATOM 2397 CD ARG B 142 3.154  5.212 −2.678 1.00 93.89 C ATOM 2398 NE ARG B 142 2.209  6.245 −3.106 1.00 95.91 N ATOM 2399 CZ ARG B 142 1.988  6.582 −4.378 1.00 96.11 C ATOM 2400 NH1 ARG B 142 2.645  5.967 −5.355 1.00 95.67 N ATOM 2401 NH2 ARG B 142 1.115  7.536 −4.676 1.00 94.93 N ATOM 2402 N ALA B 143 2.732  4.467 2.230 1.00 88.27 N ATOM 2403 CA ALA B 143 1.528  4.232 3.021 1.00 87.48 C ATOM 2404 C ALA B 143 0.684  5.481 3.234 1.00 87.63 C ATOM 2405 O ALA B 143 1.203  6.595 3.309 1.00 88.01 O ATOM 2406 CB ALA B 143 1.905  3.631 4.370 1.00 86.74 C ATOM 2407 N SER B 144 −0.627  5.279 3.341 1.00 87.89 N ATOM 2408 CA SER B 144 −1.567  6.376 3.555 1.00 87.52 C ATOM 2409 C SER B 144 −1.827  6.567 5.046 1.00 86.55 C ATOM 2410 O SER B 144 −2.926  6.945 5.450 1.00 86.03 O ATOM 2411 CB SER B 144 −2.888  6.086 2.833 1.00 88.06 C ATOM 2412 OG SER B 144 −3.463  4.871 3.283 1.00 87.49 O ATOM 2413 N PHE B 145 −0.804  6.297 5.854 1.00 86.49 N ATOM 2414 CA PHE B 145 −0.883  6.425 7.309 1.00 85.93 C ATOM 2415 C PHE B 145 0.514  6.758 7.843 1.00 84.38 C ATOM 2416 O PHE B 145 1.487  6.066 7.543 1.00 84.38 O ATOM 2417 CB PHE B 145 −1.382  5.113 7.922 1.00 87.31 C ATOM 2418 CG PHE B 145 −1.945  5.262 9.309 1.00 88.85 C ATOM 2419 CD1 PHE B 145 −3.053  6.075 9.539 1.00 89.43 C ATOM 2420 CD2 PHE B 145 −1.382  4.576 10.382 1.00 89.20 C ATOM 2421 CE1 PHE B 145 −3.594  6.204 10.819 1.00 90.00 C ATOM 2422 CE2 PHE B 145 −1.914  4.696 11.667 1.00 89.91 C ATOM 2423 CZ PHE B 145 −3.023  5.512 11.886 1.00 90.23 C ATOM 2424 N PRO B 146 0.625  7.817 8.658 1.00 82.85 N ATOM 2425 CA PRO B 146 1.899  8.259 9.236 1.00 81.70 C ATOM 2426 C PRO B 146 2.651  7.227 10.072 1.00 81.46 C ATOM 2427 O PRO B 146 3.711  7.522 10.616 1.00 81.44 O ATOM 2428 CB PRO B 146 1.491  9.475 10.058 1.00 81.64 C ATOM 2429 CG PRO B 146 0.122  9.094 10.535 1.00 82.01 C ATOM 2430 CD PRO B 146 −0.504  8.538 9.275 1.00 82.72 C ATOM 2431 N ILE B 147 2.111  6.016 10.167 1.00 81.59 N ATOM 2432 CA ILE B 147 2.738  4.963 10.961 1.00 81.02 C ATOM 2433 C ILE B 147 3.025  3.697 10.151 1.00 80.57 C ATOM 2434 O ILE B 147 2.122  2.907 9.873 1.00 79.81 O ATOM 2435 CB ILE B 147 1.844  4.608 12.167 1.00 81.33 C ATOM 2436 CG1 ILE B 147 1.638  5.857 13.034 1.00 80.74 C ATOM 2437 CG2 ILE B 147 2.473  3.481 12.972 1.00 81.16 C ATOM 2438 CD1 ILE B 147 0.615  5.689 14.134 1.00 80.93 C ATOM 2439 N ILE B 148 4.292  3.510 9.788 1.00 79.81 N ATOM 2440 CA ILE B 148 4.712  2.355 8.999 1.00 79.33 C ATOM 2441 C ILE B 148 5.495  1.366 9.848 1.00 79.72 C ATOM 2442 O ILE B 148 6.289  1.754 10.703 1.00 79.94 O ATOM 2443 CB ILE B 148 5.615  2.765 7.821 1.00 78.84 C ATOM 2444 CG1 ILE B 148 4.964  3.891 7.012 1.00 79.43 C ATOM 2445 CG2 ILE B 148 5.860  1.566 6.929 1.00 78.71 C ATOM 2446 CD1 ILE B 148 5.017  5.255 7.673 1.00 79.07 C ATOM 2447 N THR B 149 5.278  0.083 9.596 1.00 80.09 N ATOM 2448 CA THR B 149 5.960 −0.961 10.346 1.00 81.16 C ATOM 2449 C THR B 149 6.799 −1.860 9.456 1.00 81.33 C ATOM 2450 O THR B 149 6.270 −2.715 8.750 1.00 81.76 O ATOM 2451 CB THR B 149 4.956 −1.839 11.106 1.00 81.77 C ATOM 2452 OG1 THR B 149 5.595 −3.061 11.498 1.00 81.59 O ATOM 2453 CG2 THR B 149 3.749 −2.147 10.230 1.00 82.30 C ATOM 2454 N VAL B 150 8.111 −1.668 9.493 1.00 81.96 N ATOM 2455 CA VAL B 150 9.009 −2.480 8.687 1.00 82.78 C ATOM 2456 C VAL B 150 9.020 −3.905 9.236 1.00 83.55 C ATOM 2457 O VAL B 150 9.272 −4.124 10.423 1.00 82.97 O ATOM 2458 CB VAL B 150 10.442 −1.910 8.706 1.00 82.49 C ATOM 2459 CG1 VAL B 150 11.322 −2.681 7.734 1.00 83.19 C ATOM 2460 CG2 VAL B 150 10.417 −0.437 8.343 1.00 82.51 C ATOM 2461 N THR B 151 8.735 −4.868 8.363 1.00 84.78 N ATOM 2462 CA THR B 151 8.698 −6.278 8.741 1.00 86.28 C ATOM 2463 C THR B 151 10.064 −6.781 9.204 1.00 86.77 C ATOM 2464 O THR B 151 10.280 −7.005 10.394 1.00 87.05 O ATOM 2465 CB THR B 151 8.198 −7.152 7.558 1.00 86.55 C ATOM 2466 OG1 THR B 151 6.832 −6.821 7.264 1.00 86.20 O ATOM 2467 CG2 THR B 151 8.294 −8.634 7.900 1.00 86.38 C ATOM 2468 N ALA B 152 10.985 −6.957 8.263 1.00 87.52 N ATOM 2469 CA ALA B 152 12.324 −7.428 8.596 1.00 88.38 C ATOM 2470 C ALA B 152 13.181 −6.287 9.144 1.00 88.56 C ATOM 2471 O ALA B 152 13.654 −5.432 8.390 1.00 88.93 O ATOM 2472 CB ALA B 152 12.984 −8.035 7.360 1.00 89.22 C ATOM 2473 N ALA B 153 13.372 −6.276 10.461 1.00 88.08 N ATOM 2474 CA ALA B 153 14.174 −5.246 11.118 1.00 87.52 C ATOM 2475 C ALA B 153 15.626 −5.295 10.634 1.00 86.96 C ATOM 2476 O ALA B 153 16.496 −5.853 11.310 1.00 87.57 O ATOM 2477 CB ALA B 153 14.117 −5.431 12.636 1.00 86.62 C ATOM 2478 N HIS B 154 15.879 −4.709 9.463 1.00 85.74 N ATOM 2479 CA HIS B 154 17.222 −4.682 8.883 1.00 83.38 C ATOM 2480 C HIS B 154 17.975 −3.386 9.138 1.00 80.11 C ATOM 2481 O HIS B 154 17.567 −2.312 8.683 1.00 78.84 O ATOM 2482 CB HIS B 154 17.168 −4.931 7.373 1.00 85.43 C ATOM 2483 CG HIS B 154 17.206 −6.378 7.000 1.00 88.44 C ATOM 2484 ND1 HIS B 154 18.181 −7.236 7.461 1.00 88.59 N ATOM 2485 CD2 HIS B 154 16.397 −7.117 6.203 1.00 89.73 ATOM 2486 CE1 HIS B 154 17.972 −8.443 6.964 1.00 89.87 C ATOM 2487 NE2 HIS B 154 16.896 −8.398 6.198 1.00 90.21 N ATOM 2488 N SER B 155 19.082 −3.506 9.864 1.00 76.22 N ATOM 2489 CA SER B 155 19.926 −2.367 10.189 1.00 72.58 C ATOM 2490 C SER B 155 20.132 −1.521 8.934 1.00 69.83 C ATOM 2491 O SER B 155 20.286 −2.056 7.838 1.00 69.56 O ATOM 2492 CB SER B 155 21.272 −2.862 10.726 1.00 72.09 C ATOM 2493 OG SER B 155 22.115 −1.785 11.083 1.00 72.22 O ATOM 2494 N GLY B 156 20.120 −0.202 9.098 1.00 66.92 N ATOM 2495 CA GLY B 156 20.302  0.690 7.968 1.00 62.64 C ATOM 2496 C GLY B 156 19.869  2.111 8.280 1.00 60.32 C ATOM 2497 O GLY B 156 19.441  2.411 9.397 1.00 58.49 O ATOM 2498 N THR B 157 19.974  2.986 7.284 1.00 58.09 N ATOM 2499 CA THR B 157 19.606  4.390 7.435 1.00 56.19 C ATOM 2500 C THR B 157 18.276  4.704 6.750 1.00 54.12 C ATOM 2501 O THR B 157 18.150  4.557 5.540 1.00 54.88 O ATOM 2502 CB THR B 157 20.694  5.288 6.839 1.00 57.02 C ATOM 2503 OG1 THR B 157 21.952  4.968 7.448 1.00 56.76 O ATOM 2504 CG2 THR B 157 20.369  6.759 7.077 1.00 58.21 C ATOM 2505 N TYR B 158 17.294  5.150 7.528 1.00 52.00 N ATOM 2506 CA TYR B 158 15.969  5.465 6.996 1.00 49.14 C ATOM 2507 C TYR B 158 15.676  6.951 6.859 1.00 47.44 C ATOM 2508 O TYR B 158 16.245  7.779 7.564 1.00 47.07 O ATOM 2509 CB TYR B 158 14.882  4.839 7.874 1.00 49.72 C ATOM 2510 CG TYR B 158 14.882  3.336 7.859 1.00 50.84 C ATOM 2511 CD1 TYR B 158 15.852  2.611 8.544 1.00 52.22 C ATOM 2512 CD2 TYR B 158 13.933  2.634 7.123 1.00 52.04 C ATOM 2513 CE1 TYR B 158 15.877  1.222 8.494 1.00 54.89 C ATOM 2514 CE2 TYR B 158 13.946  1.246 7.063 1.00 54.25 C ATOM 2515 CZ TYR B 158 14.917  0.548 7.749 1.00 55.04 C ATOM 2516 OH TYR B 158 14.928 −0.822 7.695 1.00 57.75 O ATOM 2517 N ARG B 159 14.767  7.265 5.941 1.00 46.94 N ATOM 2518 CA ARG B 159 14.323  8.632 5.675 1.00 45.63 C ATOM 2519 C ARG B 159 12.920  8.559 5.084 1.00 44.13 C ATOM 2520 O ARG B 159 12.595  7.607 4.371 1.00 43.49 O ATOM 2521 CB ARG B 159 15.242  9.324 4.670 1.00 45.56 C ATOM 2522 CG ARG B 159 16.644  9.597 5.155 1.00 46.50 C ATOM 2523 CD ARG B 159 17.364 10.519 4.174 1.00 49.75 C ATOM 2524 NE ARG B 159 18.726 10.830 4.603 1.00 51.91 N ATOM 2525 CZ ARG B 159 19.765 10.011 4.465 1.00 52.43 C ATOM 2526 NH1 ARG B 159 19.613  8.817 3.902 1.00 51.18 N ATOM 2527 NH2 ARG B 159 20.960 10.387 4.895 1.00 53.56 N ATOM 2528 N CYS B 160 12.086  9.548 5.378 1.00 43.33 N ATOM 2529 CA CYS B 160 10.732  9.545 4.831 1.00 44.94 C ATOM 2530 C CYS B 160 10.326 10.876 4.202 1.00 43.33 C ATOM 2531 O CYS B 160 10.880 11.930 4.525 1.00 43.44 O ATOM 2532 CB CYS B 160 9.703  9.141 5.902 1.00 46.41 C ATOM 2533 SG CYS B 160 9.366 10.355 7.226 1.00 52.39 S ATOM 2534 N TYR B 161 9.365 10.801 3.286 1.00 41.73 N ATOM 2535 CA TYR B 161 8.839 11.965 2.596 1.00 39.63 C ATOM 2536 C TYR B 161 7.351 12.001 2.850 1.00 40.18 C ATOM 2537 O TYR B 161 6.725 10.957 3.009 1.00 39.82 O ATOM 2538 CB TYR B 161 9.057 11.858 1.090 1.00 39.03 C ATOM 2539 CG TYR B 161 10.497 11.771 0.660 1.00 38.99 C ATOM 2540 CD1 TYR B 161 11.183 10.555 0.668 1.00 37.63 C ATOM 2541 CD2 TYR B 161 11.167 12.901 0.206 1.00 39.46 C ATOM 2542 CE1 TYR B 161 12.498 10.473 0.222 1.00 36.81 C ATOM 2543 CE2 TYR B 161 12.478 12.831 −0.238 1.00 37.86 C ATOM 2544 CZ TYR B 161 13.136 11.619 −0.233 1.00 37.50 C ATOM 2545 OH TYR B 161 14.424 11.570 −0.709 1.00 36.65 O ATOM 2546 N SER B 162 6.781 13.199 2.880 1.00 41.15 N ATOM 2547 CA SER B 162 5.346 13.342 3.090 1.00 43.48 C ATOM 2548 C SER B 162 4.745 14.129 1.931 1.00 42.91 C ATOM 2549 O SER B 162 5.370 15.050 1.407 1.00 40.58 O ATOM 2550 CB SER B 162 5.070 14.075 4.403 1.00 46.71 C ATOM 2551 OG SER B 162 5.590 15.398 4.365 1.00 51.20 O ATOM 2552 N PHE B 163 3.536 13.758 1.526 1.00 43.64 N ATOM 2553 CA PHE B 163 2.869 14.454 0.430 1.00 44.70 C ATOM 2554 C PHE B 163 1.368 14.227 0.367 1.00 45.43 C ATOM 2555 O PHE B 163 0.823 13.359 1.056 1.00 44.79 O ATOM 2556 CB PHE B 163 3.483 14.070 −0.919 1.00 41.44 C ATOM 2557 CG PHE B 163 3.301 12.632 −1.288 1.00 39.30 C ATOM 2558 CD1 PHE B 163 4.122 11.650 −0.744 1.00 40.03 C ATOM 2559 CD2 PHE B 163 2.356 12.262 −2.239 1.00 38.32 C ATOM 2560 CE1 PHE B 163 4.014 10.318 −1.152 1.00 37.22 C ATOM 2561 CE2 PHE B 163 2.238 10.936 −2.654 1.00 38.32 C ATOM 2562 CZ PHE B 163 3.073  9.962 −2.108 1.00 39.30 C ATOM 2563 N SER B 164 0.714 15.017 −0.482 1.00 46.61 N ATOM 2564 CA SER B 164 −0.731 14.950 −0.669 1.00 48.10 C ATOM 2565 C SER B 164 −1.077 14.101 −1.887 1.00 47.89 C ATOM 2566 O SER B 164 −0.418 14.187 −2.925 1.00 47.44 O ATOM 2567 CB SER B 164 −1.292 16.368 −0.835 1.00 48.78 C ATOM 2568 OG SER B 164 −2.708 16.372 −0.864 1.00 49.70 O ATOM 2569 N SER B 165 −2.106 13.272 −1.755 1.00 48.17 N ATOM 2570 CA SER B 165 −2.530 12.413 −2.860 1.00 49.84 C ATOM 2571 C SER B 165 −3.166 13.248 −3.976 1.00 50.03 C ATOM 2572 O SER B 165 −3.491 12.736 −5.045 1.00 47.95 O ATOM 2573 CB SER B 165 −3.526 11.357 −2.358 1.00 50.70 C ATOM 2574 OG SER B 165 −4.639 11.957 −1.712 1.00 50.39 O ATOM 2575 N ARG B 166 −3.330 14.538 −3.715 1.00 51.93 N ATOM 2576 CA ARG B 166 −3.914 15.453 −4.682 1.00 55.40 C ATOM 2577 C ARG B 166 −2.841 15.895 −5.684 1.00 55.13 C ATOM 2578 O ARG B 166 −3.151 16.278 −6.813 1.00 54.44 O ATOM 2579 CB ARG B 166 −4.496 16.663 −3.953 1.00 58.95 C ATOM 2580 CG ARG B 166 −5.592 17.369 −4.715 1.00 63.83 C ATOM 2581 CD ARG B 166 −6.269 18.414 −3.844 1.00 68.76 C ATOM 2582 NE ARG B 166 −6.811 17.843 −2.610 1.00 72.15 N ATOM 2583 CZ ARG B 166 −7.672 18.472 −1.813 1.00 73.13 C ATOM 2584 NH1 ARG B 166 −8.091 19.696 −2.123 1.00 71.81 N ATOM 2585 NH2 ARG B 166 −8.121 17.878 −0.711 1.00 71.54 N ATOM 2586 N ASP B 167 −1.586 15.834 −5.243 1.00 53.13 N ATOM 2587 CA ASP B 167 −0.405 16.181 −6.038 1.00 51.71 C ATOM 2588 C ASP B 167 0.643 15.151 −5.638 1.00 50.05 C ATOM 2589 O ASP B 167 1.678 15.484 −5.052 1.00 50.09 O ATOM 2590 CB ASP B 167 0.099 17.573 −5.677 1.00 55.27 C ATOM 2591 CG ASP B 167 −0.703 18.670 −6.329 1.00 59.46 C ATOM 2592 OD1 ASP B 167 −1.948 18.638 −6.224 1.00 62.23 O ATOM 2593 OD2 ASP B 167 −0.082 19.567 −6.943 1.00 61.70 O ATOM 2594 N PRO B 168 0.384 13.878 −5.959 1.00 47.64 N ATOM 2595 CA PRO B 168 1.255 12.743 −5.650 1.00 45.81 C ATOM 2596 C PRO B 168 2.683 12.775 −6.188 1.00 45.38 C ATOM 2597 O PRO B 168 3.450 11.844 −5.932 1.00 45.41 O ATOM 2598 CB PRO B 168 0.465 11.560 −6.191 1.00 45.14 C ATOM 2599 CG PRO B 168 −0.221 12.153 −7.386 1.00 43.86 C ATOM 2600 CD PRO B 168 −0.712 13.466 −6.859 1.00 45.33 C ATOM 2601 N TYR B 169 3.041 13.833 −6.918 1.00 43.61 N ATOM 2602 CA TYR B 169 4.377 13.939 −7.495 1.00 41.62 C ATOM 2603 C TYR B 169 5.192 15.101 −6.956 1.00 42.03 C ATOM 2604 O TYR B 169 6.338 15.310 −7.374 1.00 41.65 O ATOM 2605 CB TYR B 169 4.287 14.030 −9.015 1.00 41.17 C ATOM 2606 CG TYR B 169 3.497 12.897 −9.627 1.00 41.33 C ATOM 2607 CD1 TYR B 169 3.858 11.574 −9.399 1.00 41.81 C ATOM 2608 CD2 TYR B 169 2.364 13.146 −10.397 1.00 41.00 C ATOM 2609 CE1 TYR B 169 3.107 10.524 −9.920 1.00 43.58 C ATOM 2610 CE2 TYR B 169 1.606 12.103 −10.924 1.00 41.15 C ATOM 2611 CZ TYR B 169 1.981 10.795 −10.680 1.00 42.13 C ATOM 2612 OH TYR B 169 1.233  9.753 −11.185 1.00 42.73 O ATOM 2613 N LEU B 170 4.597 15.860 −6.040 1.00 40.59 N ATOM 2614 CA LEU B 170 5.288 16.976 −5.404 1.00 41.48 C ATOM 2615 C LEU B 170 5.542 16.540 −3.965 1.00 41.75 C ATOM 2616 O LEU B 170 4.629 16.563 −3.134 1.00 43.88 O ATOM 2617 CB LEU B 170 4.433 18.242 −5.412 1.00 41.02 C ATOM 2618 CG LEU B 170 4.092 18.867 −6.767 1.00 42.48 C ATOM 2619 CD1 LEU B 170 3.473 20.244 −6.530 1.00 40.89 C ATOM 2620 CD2 LEU B 170 5.346 18.987 −7.624 1.00 39.31 C ATOM 2621 N TRP B 171 6.779 16.134 −3.679 1.00 39.70 N ATOM 2622 CA TRP B 171 7.153 15.657 −2.348 1.00 37.80 C ATOM 2623 C TRP B 171 7.946 16.653 −1.509 1.00 37.65 C ATOM 2624 O TRP B 171 8.649 17.528 −2.028 1.00 37.20 O ATOM 2625 CB TRP B 171 7.973 14.370 −2.463 1.00 35.99 C ATOM 2626 CG TRP B 171 7.223 13.148 −2.939 1.00 35.37 C ATOM 2627 CD1 TRP B 171 5.992 13.101 −3.543 1.00 33.72 C ATOM 2628 CD2 TRP B 171 7.700 11.795 −2.898 1.00 34.98 C ATOM 2629 NE1 TRP B 171 5.681 11.801 −3.880 1.00 32.40 N ATOM 2630 CE2 TRP B 171 6.712 10.983 −3.495 1.00 33.28 C ATOM 2631 CE3 TRP B 171 8.871 11.194 −2.414 1.00 33.28 C ATOM 2632 CZ2 TRP B 171 6.860  9.604 −3.618 1.00 33.96 C ATOM 2633 CZ3 TRP B 171 9.016  9.825 −2.538 1.00 33.23 C ATOM 2634 CH2 TRP B 171 8.017  9.044 −3.135 1.00 34.26 C ATOM 2635 N SER B 172 7.839 16.492 −0.195 1.00 36.76 N ATOM 2636 CA SER B 172 8.549 17.344 0.750 1.00 36.21 C ATOM 2637 C SER B 172 10.035 17.028 0.711 1.00 34.22 C ATOM 2638 O SER B 172 10.479 16.161 −0.035 1.00 32.71 O ATOM 2639 CB SER B 172 8.048 17.075 2.163 1.00 36.67 C ATOM 2640 OG SER B 172 8.421 15.765 2.561 1.00 38.14 O ATOM 2641 N ALA B 173 10.802 17.747 1.518 1.00 35.35 N ATOM 2642 CA ALA B 173 12.229 17.482 1.619 1.00 36.59 C ATOM 2643 C ALA B 173 12.273 16.230 2.479 1.00 36.92 C ATOM 2644 O ALA B 173 11.375 15.997 3.292 1.00 36.79 O ATOM 2645 CB ALA B 173 12.947 18.626 2.326 1.00 35.55 C ATOM 2646 N PRO B 174 13.299 15.394 2.299 1.00 37.01 N ATOM 2647 CA PRO B 174 13.398 14.172 3.097 1.00 37.67 C ATOM 2648 C PRO B 174 13.560 14.509 4.567 1.00 38.39 C ATOM 2649 O PRO B 174 14.076 15.574 4.915 1.00 39.36 O ATOM 2650 CB PRO B 174 14.643 13.497 2.534 1.00 38.05 C ATOM 2651 CG PRO B 174 15.501 14.666 2.171 1.00 37.71 C ATOM 2652 CD PRO B 174 14.504 15.578 1.475 1.00 38.40 C ATOM 2653 N SER B 175 13.111 13.607 5.429 1.00 37.76 N ATOM 2654 CA SER B 175 13.246 13.814 6.865 1.00 38.89 C ATOM 2655 C SER B 175 14.708 13.581 7.233 1.00 37.67 C ATOM 2656 O SER B 175 15.474 13.029 6.438 1.00 37.63 O ATOM 2657 CB SER B 175 12.400 12.797 7.621 1.00 39.16 C ATOM 2658 OG SER B 175 12.895 11.490 7.361 1.00 41.30 O ATOM 2659 N ASP B 176 15.102 14.010 8.427 1.00 38.07 N ATOM 2660 CA ASP B 176 16.464 13.757 8.881 1.00 38.39 C ATOM 2661 C ASP B 176 16.540 12.235 8.949 1.00 37.45 C ATOM 2662 O ASP B 176 15.556 11.570 9.266 1.00 36.92 O ATOM 2663 CB ASP B 176 16.711 14.342 10.274 1.00 38.96 C ATOM 2664 CG ASP B 176 16.723 15.853 10.277 1.00 41.25 C ATOM 2665 OD1 ASP B 176 17.423 16.435 9.423 1.00 44.24 O ATOM 2666 OD2 ASP B 176 16.041 16.457 11.132 1.00 40.46 O ATOM 2667 N PRO B 177 17.710 11.662 8.655 1.00 37.29 N ATOM 2668 CA PRO B 177 17.836 10.205 8.697 1.00 35.33 C ATOM 2669 C PRO B 177 17.708  9.631 10.100 1.00 34.97 C ATOM 2670 O PRO B 177 18.153 10.232 11.070 1.00 32.31 O ATOM 2671 CB PRO B 177 19.217  9.973 8.099 1.00 36.66 C ATOM 2672 CG PRO B 177 19.984 11.159 8.608 1.00 34.54 C ATOM 2673 CD PRO B 177 19.017 12.309 8.437 1.00 35.30 C ATOM 2674 N LEU B 178 17.067  8.474 10.194 1.00 35.63 N ATOM 2675 CA LEU B 178 16.914  7.776 11.461 1.00 36.55 C ATOM 2676 C LEU B 178 17.749  6.524 11.266 1.00 38.19 C ATOM 2677 O LEU B 178 17.414  5.676 10.435 1.00 38.99 O ATOM 2678 CB LEU B 178 15.452  7.390 11.708 1.00 36.81 C ATOM 2679 CG LEU B 178 15.126  6.590 12.979 1.00 36.90 C ATOM 2680 CD1 LEU B 178 13.619  6.569 13.202 1.00 37.36 C ATOM 2681 CD2 LEU B 178 15.663  5.172 12.864 1.00 35.47 C ATOM 2682 N GLU B 179 18.838  6.407 12.015 1.00 38.87 N ATOM 2683 CA GLU B 179 19.712  5.249 11.883 1.00 39.46 C ATOM 2684 C GLU B 179 19.207  4.050 12.677 1.00 39.46 C ATOM 2685 O GLU B 179 19.209  4.054 13.906 1.00 39.73 O ATOM 2686 CB GLU B 179 21.117  5.610 12.348 1.00 42.21 C ATOM 2687 CG GLU B 179 22.182  4.631 11.898 1.00 47.32 C ATOM 2688 CD GLU B 179 22.362  4.635 10.394 1.00 50.57 C ATOM 2689 OE1 GLU B 179 22.500  5.740 9.823 1.00 50.52 O ATOM 2690 OE2 GLU B 179 22.374  3.540 9.786 1.00 53.02 O ATOM 2691 N LEU B 180 18.763  3.020 11.975 1.00 39.19 N ATOM 2692 CA LEU B 180 18.283  1.827 12.641 1.00 38.79 C ATOM 2693 C LEU B 180 19.466  0.886 12.811 1.00 41.64 C ATOM 2694 O LEU B 180 20.148  0.562 11.843 1.00 43.68 O ATOM 2695 CB LEU B 180 17.208  1.142 11.801 1.00 37.03 C ATOM 2696 CG LEU B 180 16.705 −0.200 12.339 1.00 39.04 C ATOM 2697 CD1 LEU B 180 15.938  0.022 13.632 1.00 38.67 C ATOM 2698 CD2 LEU B 180 15.817 −0.879 11.307 1.00 39.98 C ATOM 2699 N VAL B 181 19.723  0.442 14.032 1.00 43.73 N ATOM 2700 CA VAL B 181 20.833 −0.473 14.239 1.00 46.11 C ATOM 2701 C VAL B 181 20.473 −1.639 15.167 1.00 48.00 C ATOM 2702 O VAL B 181 20.251 −1.462 16.365 1.00 47.48 O ATOM 2703 CB VAL B 181 22.074  0.290 14.747 1.00 44.36 C ATOM 2704 CG1 VAL B 181 21.670  1.291 15.794 1.00 44.70 C ATOM 2705 CG2 VAL B 181 23.099 −0.687 15.286 1.00 45.60 C ATOM 2706 N VAL B 182 20.399 −2.833 14.583 1.00 50.37 N ATOM 2707 CA VAL B 182 20.056 −4.038 15.326 1.00 54.73 C ATOM 2708 C VAL B 182 21.298 −4.827 15.725 1.00 56.59 C ATOM 2709 O VAL B 182 22.177 −5.101 14.901 1.00 57.26 O ATOM 2710 CB VAL B 182 19.108 −4.962 14.507 1.00 55.51 C ATOM 2711 CG1 VAL B 182 19.645 −5.152 13.102 1.00 58.24 C ATOM 2712 CG2 VAL B 182 18.983 −6.317 15.189 1.00 55.52 C ATOM 2713 N THR B 183 21.357 −5.189 17.001 1.00 58.09 N ATOM 2714 CA THR B 183 22.482 −5.940 17.537 1.00 60.50 C ATOM 2715 C THR B 183 22.185 −7.445 17.610 1.00 61.32 C ATOM 2716 O THR B 183 22.345 −8.038 18.698 1.00 63.07 O ATOM 2717 CB THR B 183 22.850 −5.411 18.941 1.00 60.64 C ATOM 2718 OG1 THR B 183 21.683 −5.414 19.773 1.00 60.72 O ATOM 2719 CG2 THR B 183 23.393 −3.990 18.849 1.00 59.96 C ATOM 2720 OXT THR B 183 21.804 −8.022 16.569 1.00 60.88 O TER 2721 THR B 183 HETATM 2722 S SO4 203 27.448 30.064 35.300 1.00 67.63 S HETATM 2723 O1 SO4 203 27.917 28.680 35.471 1.00 69.01 O HETATM 2724 O2 SO4 203 26.041 30.164 35.740 1.00 68.17 O HETATM 2725 O3 SO4 203 28.286 30.956 36.127 1.00 66.05 O HETATM 2726 O4 SO4 203 27.541 30.442 33.876 1.00 65.80 O HETATM 2727 S SO4 204 17.095 36.631 37.561 1.00 89.60 S HETATM 2728 O1 SO4 204 18.070 36.485 36.461 1.00 89.38 O HETATM 2729 O2 SO4 204 17.623 35.965 38.768 1.00 87.90 O HETATM 2730 O3 SO4 204 16.884 38.070 37.829 1.00 89.18 O HETATM 2731 O4 SO4 204 15.812 36.007 37.180 1.00 88.34 O HETATM 2732 CL CL 205 0.622 14.858 −13.729 1.00 48.19 C HETATM 2733 O1 CRY 201 8.494 26.546 −13.798 1.00 61.77 O HETATM 2734 O2 CRY 201 6.980 25.532 −10.933 1.00 58.36 O HETATM 2735 O3 CRY 201 9.339 25.778 −9.263 1.00 57.45 O HETATM 2736 C1 CRY 201 7.989 27.017 −12.560 1.00 59.96 C HETATM 2737 C2 CRY 201 8.219 26.015 −11.426 1.00 58.27 C HETATM 2738 C3 CRY 201 9.033 26.676 −10.326 1.00 57.99 C HETATM 2739 O1 CRY 202 22.596 19.139 32.420 1.00 74.69 O HETATM 2740 O2 CRY 202 22.195 15.532 32.582 1.00 74.29 O HETATM 2741 O3 CRY 202 19.369 16.082 32.439 1.00 74.07 O HETATM 2742 C1 CRY 202 22.671 17.818 31.896 1.00 75.74 C HETATM 2743 C2 CRY 202 21.676 16.857 32.567 1.00 74.89 C HETATM 2744 C3 CRY 202 20.351 16.912 31.832 1.00 75.05 C HETATM 2745 O HOH 1 9.345 35.972 36.041 1.00 49.87 O HETATM 2746 O HOH 2 29.477 29.132 31.866 1.00 39.19 O HETATM 2747 O HOH 3 19.793 14.003 −6.560 1.00 50.40 O HETATM 2748 O HOH 4 3.634  7.951 −26.066 1.00 48.23 O HETATM 2749 O HOH 5 21.577 24.558 14.056 1.00 51.29 O HETATM 2750 O HOH 6 20.673 30.352 51.927 1.00 27.82 O HETATM 2751 O HOH 7 20.713 13.953 −15.139 1.00 31.87 O HETATM 2752 O HOH 8 2.444  2.099 −16.613 1.00 43.60 O HETATM 2753 O HOH 9 1.078  1.378 −35.388 1.00 33.34 O HETATM 2754 O HOH 10 8.708 25.978 −17.078 1.00 50.29 O HETATM 2755 O HOH 11 11.777 22.999 2.803 1.00 50.81 O HETATM 2756 O HOH 12 −1.565  8.014 −21.599 1.00 58.93 O HETATM 2757 O HOH 13 0.913  8.830 −24.759 1.00 47.61 O HETATM 2758 O HOH 14 28.087 30.051 45.339 1.00 35.99 O HETATM 2759 O HOH 15 18.475 13.354 4.405 1.00 38.26 O HETATM 2760 O HOH 16 14.005 18.288 25.649 1.00 44.08 O HETATM 2761 O HOH 17 22.120 21.625 13.143 1.00 46.12 O HETATM 2762 O HOH 18 25.578  4.080 12.461 1.00 46.48 O HETATM 2763 O HOH 19 16.696 18.298 51.473 1.00 34.69 O HETATM 2764 O HOH 20 16.065 20.866 19.361 1.00 32.66 O HETATM 2765 O HOH 21 14.927 16.895 20.392 1.00 41.92 O HETATM 2766 O HOH 22 15.199 43.247 49.855 1.00 69.19 O HETATM 2767 O HOH 23 11.592 11.810 −38.128 1.00 64.49 O HETATM 2768 O HOH 24 29.391 33.117 33.755 1.00 37.74 O HETATM 2769 O HOH 25 18.865 32.204 59.266 1.00 39.13 O HETATM 2770 O HOH 26 21.302 11.936 0.261 1.00 72.54 O HETATM 2771 O HOH 27 27.812  5.521 9.687 1.00 52.88 O HETATM 2772 O HOH 28 12.963 20.941 5.215 1.00 52.75 O HETATM 2773 O HOH 29 29.083 24.701 38.577 1.00 65.83 O HETATM 2774 O HOH 30 16.555 11.924 −4.419 1.00 46.70 O HETATM 2775 O HOH 31 18.831 20.610 39.628 1.00 37.46 O HETATM 2776 O HOH 32 8.629  5.970 −12.408 1.00 45.59 O HETATM 2777 O HOH 33 19.170 16.184 47.559 1.00 57.57 O HETATM 2778 O HOH 34 10.757 23.307 42.419 1.00 35.08 O HETATM 2779 O HOH 35 23.584 14.112 −14.334 1.00 51.67 O HETATM 2780 O HOH 36 13.341 38.357 36.930 1.00 46.55 O HETATM 2781 O HOH 37 17.751 12.572 −11.035 1.00 37.79 O HETATM 2782 O HOH 38 27.123  2.637 30.993 1.00 52.80 O HETATM 2783 O HOH 39 22.781 27.082 14.239 1.00 49.68 O HETATM 2784 O HOH 40 33.837  2.899 12.534 1.00 42.25 O HETATM 2785 O HOH 41 26.665 36.131 23.687 1.00 52.46 O HETATM 2786 O HOH 42 6.541 33.983 42.116 1.00 56.94 O HETATM 2787 O HOH 43 21.407 20.886 −1.230 1.00 47.27 O HETATM 2788 O HOH 44 22.534  2.711 −21.085 1.00 54.19 O HETATM 2789 O HOH 45 −1.055 18.564 −12.432 1.00 50.37 O HETATM 2790 O HOH 46 17.195 11.052 −30.319 1.00 37.25 O HETATM 2791 O HOH 47 22.773 21.850 47.235 1.00 41.52 O HETATM 2792 O HOH 48 30.408 22.549 34.895 1.00 52.22 O HETATM 2793 O HOH 49 4.125 20.975 −18.103 1.00 46.93 O HETATM 2794 O HOH 50 −1.611 21.121 2.063 1.00 53.12 O HETATM 2795 O HOH 51 24.397 15.163 10.642 1.00 42.65 O HETATM 2796 O HOH 52 20.020 19.587 51.778 1.00 45.69 O HETATM 2797 O HOH 53 14.697  5.748 −9.674 1.00 41.66 O HETATM 2798 O HOH 54 27.831 27.970 29.867 1.00 33.90 O HETATM 2799 O HOH 55 13.676 10.838 −33.233 1.00 34.24 O HETATM 2800 O HOH 56 23.207 20.593 10.696 1.00 45.13 O HETATM 2801 O HOH 57 −2.683  6.783 −18.369 1.00 66.64 O HETATM 2802 O HOH 58 11.623 40.422 43.131 1.00 43.32 O HETATM 2803 O HOH 59 14.028 23.139 18.371 1.00 63.51 O HETATM 2804 O HOH 60 14.159 18.446 −25.758 1.00 58.73 O HETATM 2805 O HOH 61 10.698 20.528 −25.480 1.00 68.18 O HETATM 2806 O HOH 62 3.987  8.914 −6.190 1.00 56.87 O HETATM 2807 O HOH 63 9.046  4.439 −17.164 1.00 33.61 O HETATM 2808 O HOH 64 15.572 15.955 26.055 1.00 54.13 O HETATM 2809 O HOH 65 14.765 14.388 13.517 1.00 49.30 O HETATM 2810 O HOH 66 21.516 15.358 8.600 1.00 38.76 O HETATM 2811 O HOH 67 15.186 13.626 −2.068 1.00 40.17 O HETATM 2812 O HOH 68 15.486 −2.827 26.343 1.00 53.38 O HETATM 2813 O HOH 69 15.530 22.799 −15.739 1.00 38.93 O HETATM 2814 O HOH 70 17.145 15.805 21.705 1.00 52.06 O HETATM 2815 O HOH 71 14.137 11.634 11.877 1.00 38.80 O HETATM 2816 O HOH 72 12.665 11.118 26.076 1.00 48.60 O HETATM 2817 O HOH 73 17.385 21.388 45.846 1.00 38.81 O HETATM 2818 O HOH 74 28.611 20.108 34.705 1.00 58.52 O HETATM 2819 O HOH 75 23.192 21.527 −8.071 1.00 56.38 O HETATM 2820 O HOH 76 20.826 15.112 −9.585 1.00 38.08 O HETATM 2821 O HOH 77 17.464 15.250 14.230 1.00 51.91 O HETATM 2822 O HOH 78 1.295 11.432 −29.725 1.00 59.93 O HETATM 2823 O HOH 79 10.556 10.787 29.467 1.00 52.79 O HETATM 2824 O HOH 80 23.540 24.190 46.289 1.00 31.37 O HETATM 2825 O HOH 81 24.176 11.097 −12.886 1.00 63.38 O HETATM 2826 O HOH 82 19.791 21.221 37.227 1.00 37.15 O HETATM 2827 O HOH 83 14.614 20.920 36.628 1.00 30.32 O HETATM 2828 O HOH 84 21.408 17.270 46.517 1.00 58.01 O HETATM 2829 O HOH 85 22.190 23.220 50.321 1.00 43.16 O HETATM 2830 O HOH 86 18.149 13.017 −8.335 1.00 39.78 O HETATM 2831 O HOH 87 27.271 20.790 31.675 1.00 45.02 O HETATM 2832 O HOH 88 12.253 19.174 17.551 1.00 46.46 O HETATM 2833 O HOH 89 18.108 17.291 1.907 1.00 48.10 O HETATM 2834 O HOH 90 17.148 15.903 −0.509 1.00 48.37 O HETATM 2835 O HOH 91 32.390 26.731 34.200 1.00 52.46 O HETATM 2836 O HOH 92 20.733 25.649 66.071 1.00 55.95 O HETATM 2837 O HOH 93 18.109 13.559 −0.549 1.00 55.88 O HETATM 2838 O HOH 94 17.988 24.631 −3.754 1.00 51.13 O HETATM 2839 O HOH 95 11.147 25.599 7.464 1.00 54.03 O HETATM 2840 O HOH 96 0.669 20.153 −14.220 1.00 61.13 O HETATM 2841 O HOH 97 23.423 16.822 7.820 1.00 47.11 O HETATM 2842 O HOH 98 4.169 28.368 47.401 1.00 49.11 O HETATM 2843 O HOH 99 17.907 22.480 19.908 1.00 25.19 O HETATM 2844 O HOH 100 18.913 18.483 −1.892 1.00 42.00 O HETATM 2845 O HOH 101 29.430 25.548 35.765 1.00 52.14 O HETATM 2846 O HOH 102 7.533 37.946 49.399 1.00 47.42 O HETATM 2847 O HOH 103 4.559 −5.686 −35.297 1.00 33.47 O HETATM 2848 O HOH 104 16.365 21.287 43.112 1.00 37.52 O HETATM 2849 O HOH 105 12.647 22.707 26.991 1.00 40.89 O HETATM 2850 O HOH 106 17.387  8.577 −4.168 1.00 58.00 O HETATM 2851 O HOH 107 19.144 38.706 55.887 1.00 54.56 O HETATM 2852 O HOH 108 29.881 −10.278  30.643 1.00 59.44 O HETATM 2853 O HOH 109 27.905 36.586 33.075 1.00 72.69 O HETATM 2854 O HOH 110 15.881  4.099 −21.160 1.00 46.82 O HETATM 2855 O HOH 111 25.849 −5.581 21.859 1.00 64.80 O HETATM 2856 O HOH 112 35.376 10.168 11.497 1.00 64.49 O HETATM 2857 O HOH 113 6.943 38.954 37.146 1.00 58.18 O HETATM 2858 O HOH 114 13.626 21.235 15.770 1.00 57.55 O HETATM 2859 O HOH 115 20.479  9.262 11.648 1.00 34.66 O HETATM 2860 O HOH 116 33.288 14.468 17.531 1.00 44.57 O HETATM 2861 O HOH 117 1.569 15.732 −8.368 1.00 32.82 O HETATM 2862 O HOH 118 27.694  8.889 31.895 1.00 42.30 O HETATM 2863 O HOH 119 15.732 20.157 −2.274 1.00 46.93 O HETATM 2864 O HOH 120 −3.393 16.381 1.929 1.00 44.37 O HETATM 2865 O HOH 121 1.833 16.793 −2.687 1.00 35.38 O HETATM 2866 O HOH 122 27.991 −4.809 19.258 1.00 51.85 O HETATM 2867 O HOH 123 −3.494 13.598 −9.407 1.00 60.31 O HETATM 2868 O HOH 124 12.591 16.103 21.706 1.00 53.70 O HETATM 2869 O HOH 125 8.516  0.694 −20.459 1.00 38.88 O HETATM 2870 O HOH 126 8.891 36.072 47.904 1.00 47.38 O HETATM 2871 O HOH 127 4.793 −6.174 −27.894 1.00 54.09 O HETATM 2872 O HOH 128 12.115 36.278 31.925 1.00 44.39 O HETATM 2873 O HOH 129 12.645 38.231 34.367 1.00 47.38 O HETATM 2874 O HOH 130 −0.374  1.306 −18.286 1.00 43.50 O HETATM 2875 O HOH 131 1.435 −5.901 −28.903 1.00 59.12 O HETATM 2876 O HOH 132 3.606 −4.066 −21.697 1.00 53.36 O HETATM 2877 O HOH 133 7.722  6.537 −6.384 1.00 59.86 O HETATM 2878 O HOH 134 32.764 −3.214 23.681 1.00 66.32 O HETATM 2879 O HOH 135 11.444 29.479 68.519 1.00 52.15 O HETATM 2880 O HOH 136 17.708 32.932 21.066 1.00 46.20 O HETATM 2881 O HOH 137 24.356  8.033 11.474 1.00 42.27 O HETATM 2882 O HOH 138 37.871 32.641 28.378 1.00 53.68 O HETATM 2883 O HOH 139 22.791  4.294 −18.714 1.00 42.79 O HETATM 2884 O HOH 140 20.508 17.110 50.703 1.00 45.09 O HETATM 2885 O HOH 141 12.008 41.980 48.992 1.00 69.99 O HETATM 2886 O HOH 142 7.076 34.223 23.515 1.00 56.38 O HETATM 2887 O HOH 143 13.346  5.425 −13.549 1.00 48.33 O HETATM 2888 O HOH 144 1.946  8.698 −30.959 1.00 63.85 O HETATM 2889 O HOH 145 12.922 22.533 7.109 1.00 54.73 O HETATM 2890 O HOH 146 8.710 −2.537 −38.383 1.00 58.89 O HETATM 2891 O HOH 147 21.767  5.803 32.948 1.00 61.52 O HETATM 2892 O HOH 148 24.812  6.711 −18.661 1.00 52.13 O HETATM 2893 O HOH 149 4.802 23.746 32.504 1.00 63.10 O HETATM 2894 O HOH 150 −5.626  7.875 1.548 1.00 48.19 O HETATM 2895 O HOH 151 10.718 37.270 24.721 1.00 53.57 O HETATM 2896 O HOH 152 26.659 −2.956 16.507 1.00 53.28 O HETATM 2897 O HOH 153 16.908 13.134 −34.370 1.00 56.42 O HETATM 2898 O HOH 154 30.127 23.186 11.723 1.00 54.72 O HETATM 2899 O HOH 155 17.814 37.129 57.927 1.00 53.40 O HETATM 2900 O HOH 156 34.904 −1.525 23.222 1.00 44.82 O HETATM 2901 O HOH 157 0.630  3.969 19.265 1.00 64.63 O HETATM 2902 O HOH 158 2.852  8.449 18.136 1.00 46.43 O HETATM 2903 O HOH 159 10.548  5.464 −6.260 1.00 59.31 O HETATM 2904 O HOH 160 17.519 20.643 −22.015 1.00 27.50 O HETATM 2905 O HOH 161 5.642 20.599 31.550 1.00 49.79 O HETATM 2906 O HOH 162 6.127 11.707 32.248 1.00 64.27 O HETATM 2907 O HOH 163 13.295 17.527 37.772 1.00 57.93 O HETATM 2908 O HOH 164 23.610 22.112 6.595 1.00 58.06 O HETATM 2909 O HOH 165 9.245 37.107 32.386 1.00 46.35 O HETATM 2910 O HOH 166 11.302 16.597 35.016 1.00 47.51 O HETATM 2911 O HOH 167 39.408 19.148 22.624 1.00 67.29 O HETATM 2912 O HOH 168 13.285 13.827 23.371 1.00 53.16 O HETATM 2913 O HOH 169 35.794  0.803 12.173 1.00 48.76 O HETATM 2914 O HOH 170 26.327 23.228 39.153 1.00 53.68 O HETATM 2915 O HOH 171 −2.607 11.697 −24.443 1.00 59.86 O HETATM 2916 O HOH 172 −0.424  3.799 −22.256 1.00 49.47 O HETATM 2917 O HOH 173 17.815 12.725 −28.023 1.00 46.50 O HETATM 2918 O HOH 174 0.000 22.643 52.435 1.00 29.85 O HETATM 2919 O HOH 175 0.000 22.643 0.783 1.00 19.44 O HETATM 2920 O HOH 176 0.000  0.000 14.870 1.00 19.44 O HETATM 2921 O HOH 177 0.000  0.000 −33.652 1.00 22.06 O END 

1. A method of identifying an inhibitor of GPVI collagen binding activity, the method comprising: (1) designing or selecting a potential inhibitor using a three-dimensional structure of the GPVI collagen binding domain comprising main chain and side chain atoms and as defined by atomic coordinates set forth in Table 2, plus or minus a root mean square deviation for the main chain atoms of not greater than 2 Angstroms; (2) synthesizing or obtaining the potential inhibitor; and (3) determining whether the potential inhibitor inhibits the activity of GPVI, wherein designing or selecting a potential inhibitor employs computer modeling.
 2. The method according to claim 1, wherein determining whether the potential inhibitor inhibits the activity of GPVI is performed using a protein binding assay or an inhibition assay.
 3. The method according to claim 1, wherein determining whether the potential inhibitor inhibits the activity of GPVI is performed using a cellular-based assay.
 4. The method according to claim 1, wherein determining whether the potential inhibitor inhibits the activity of GPVI comprises contacting the potential inhibitor with GPVI in the presence of a known ligand, determining the ability of the potential inhibitor to compete with the known GPVI collagen binding domain ligand and screening the potential inhibitor of GPVI in an assay for efficacy in inhibiting GPVI.
 5. The method according to claim 4, wherein the known ligand is selected from the group consisting of collagen, CRP and convulxin.
 6. A method for designing binding agents that interact with the GPVI collagen binding domain, the method comprising: employing at least some of the atomic coordinates set forth in Table
 2. 7. A method of screening a library of compounds for potential to bind to the GPVI collagen binding domain, the method comprising: using at least some of the atomic coordinates set forth Table 2 to perform computational docking of the library of compounds to the GPVI collagen binding domain.
 8. A method of identifying a compound useful for the treatment of a GPVI-mediated disorder, comprising the steps of: (a) using a three-dimensional structure of the GPVI collagen binding domain as defined by at least some of the atomic coordinates set forth in Table 2, and (b) employing the structure to design, modify, or select a compound that modulates GPVI activity.
 9. The method according to claim 8, wherein the GPVI modulator is useful in the prevention or treatment of a vascular disorder.
 10. The method according to claim 9, wherein the vascular disorder comprises a thrombotic disorder.
 11. The method according to claim 8, wherein the GPVI collagen binding domain comprises at least some or all of residues K41, S43, S44, R46, Q48, Q50, L53, F54, I55, P56, K59, S61, L62, Y66, and R166.
 12. A method of designing or selecting agents that bind to the collagen binding domain of GPVI according to claim 2, the method comprising the use of at least some of the atomic coordinates set forth in Table 2 to perform computer modeling.
 13. The method according to claim 12, wherein two designed or selected agents are connected by a crosslinker of appropriate length to permit bivalent binding to the dimeric form of GPVI observed in the crystal. 